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31.发明申请公开(公告)号：US20200315479A1
公开(公告)日：2020-10-08
申请号：US16759277
申请日：2018-10-25
Inventor： Taeghwan HYEON , Daehyeong KIM , Sangihn HAN , Suji CHOI , Dongjun JUNG
Abstract: A core-shell nanowire, a method of forming the core-shell nanowire and a stretchable composite comprising the core-shell nanowire are provided. The core-shell nanowire comprises a core comprising a conductive metal and a shell comprising a biocompatible metal. The method of forming the core-shell nanowire comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal. The stretchable composite comprises a first core-shell nanowire/polymer composite comprising first core-shell nanowires and a first polymer, a first insulating layer disposed on the first core-shell nanowire/polymer composite, and a second core-shell nanowire/polymer composite disposed on the first insulating layer and comprising second core-shell nanowires and a second polymer.
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公开(公告)号：US10770718B2
公开(公告)日：2020-09-08
申请号：US15913687
申请日：2018-03-06
Inventor： Yung-Eun Sung , Chunjoong Kim , Jungjin Park
Abstract: A lithium-sulfur secondary battery includes a cathode current collector and a cathode electrode on the cathode current collector. The cathode electrode includes a porous carbon interlayer electrode including a plurality of carbon fibers, metal sulfide catalyst particles dispersed and positioned on the porous carbon interlayer electrode, and sulfur-based active material particles dispersed on the porous carbon interlayer electrode to be attached thereto and including sulfur.
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公开(公告)号：US10745472B2
公开(公告)日：2020-08-18
申请号：US16473685
申请日：2017-12-19
Inventor： Gou Young Koh , Jaeryung Kim , Do Young Park
IPC: A61K39/395 , A61K39/00 , C07K16/22 , A61P27/02 , A61P27/06
Abstract: The present invention relates to a composition which is for preventing and treating eye diseases and comprises an anti-angiopoietin-2 (Ang2) antibody and, more specifically, to a novel use of an anti-Ang2 antibody as an agent for preventing or treating eye diseases, wherein the anti-Ang2 antibody is specifically coupled to Ang2, is coupled to a Tie2 receptor together with Ang2, and has improved affinity. The composition according to the present invention can be usefully used to develop a treatment agent for macular degeneration, diabetic retinopathy, and glaucoma.
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公开(公告)号：US10704099B2
公开(公告)日：2020-07-07
申请号：US15736949
申请日：2016-06-17
Inventor： Keetae Kim , Hong Gil Nam , Chand Parvez Danka Mohammed
IPC: C12Q1/6883 , C12N15/113 , G01N33/50 , G01N33/68
Abstract: The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.
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公开(公告)号：US20200030236A1
公开(公告)日：2020-01-30
申请号：US16467943
申请日：2016-12-07
Inventor： Daehyeong KIM , Seunghong CHOI , Taeghwan HYEON , Jongha LEE , Hyerim CHO , Hyunseon SEO
Abstract: A biopatch, a bioheater, a biosensor and a bioelectronic patch device are provided.The biopatch comprises a polymer film comprising a biopolymer and a drug loaded in the polymer film. The biopolymer may comprise one or more than one of a bioabsorbable polymer, a biodegradable polymer and a biocompatible polymer. The biopolymer may comprise oxidized starch. The drug may comprise a first drug chemically combined with the oxidized starch and a second drug physically combined with the oxidized starch.The bioheater comprises a heater comprising biometal. The biometal may comprise Mg or Fe. The heater can be controlled wirelessly by an alternating magnetic field.A biosensor according to one embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, each of the inductor, the first electrode and the second electrode comprises biometal, and the dielectric comprises a biopolymer having a glass transition temperature in a range of 36˜42° C. A biosensor according to another embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, a change in a dielectric constant of the dielectric is transmitted to an external device through a resonance frequency change with the inductor, and the external device measures temperature around the biosensor by measuring the resonance frequency change wirelessly.A bioelectronic patch device according to one embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, and a heater adjacent to the drug patch to heat the drug patch. A bioelectronic patch device according to another embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, a first protection layer disposed on the drug patch, a heater disposed on the first protection layer and heating the drug patch, a temperature sensor disposed on the first protection layer, spaced apart from the heater and measuring temperature of the heater, and a second protection layer covering the heater and the temperature sensor on the first protection layer.
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Patent Agency Ranking
公开(公告)号：US20190330324A1
公开(公告)日：2019-10-31
申请号：US16473685
申请日：2017-12-19
Inventor： Gou Young KOH , Jaeryung KIM , Do Young PARK
Abstract: The present invention relates to a composition which is for preventing and treating eye diseases and comprises an anti-angiopoietin-2 (Ang2) antibody and, more specifically, to a novel use of an anti-Ang2 antibody as an agent for preventing or treating eye diseases, wherein the anti-Ang2 antibody is specifically coupled to Ang2, is coupled to a Tie2 receptor together with Ang2, and has improved affinity. The composition according to the present invention can be usefully used to develop a treatment agent for macular degeneration, diabetic retinopathy, and glaucoma.
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37.发明授权公开(公告)号：US10301332B2
公开(公告)日：2019-05-28
申请号：US15359474
申请日：2016-11-22
Inventor： Won Jong Kim , Jihoon Kim , Hyung Woo Choi
IPC: C07F7/18 , B01J20/04 , B01J20/22 , A61K33/00 , C01B21/24 , A61K31/655 , A61K31/695 , A61K47/54 , A61K47/69 , B82Y5/00
Abstract: Provided is a method of controlling release of nitric oxide, and more particularly, to a method of selectively releasing nitric oxide depending on a change in pH using calcium phosphate.The method of selectively releasing nitric oxide according to the present invention may stably deliver nitric oxide to a desired site, and induce release of nitric oxide by a change in pH, thereby making it possible to improve a therapeutic effect while preventing a loss of nitric oxide.
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公开(公告)号：US20190092839A1
公开(公告)日：2019-03-28
申请号：US15742874
申请日：2016-12-21
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Won Do HEO , Yun Ju LEE , Daseuli YU , Byung Ouk PARK
Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.
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公开(公告)号：US20180266891A1
公开(公告)日：2018-09-20
申请号：US15982303
申请日：2018-05-17
Inventor： Kyung-Taec KIM , Chang-Hee Nam , Seung-Beom Park , Wo-Sik Cho , Kyung-Seung Kim
Abstract: The present invention relates to a apparatus and method for measuring a waveform of a light wave. A light wave measurement apparatus according to an embodiment of the present invention includes a pulse separation unit to separate an input light wave into a fundamental pulse and a signal pulse, a time delay adjustment unit to adjust a time delay between the fundamental pulse and the signal pulse, a focusing unit to focus the fundamental pulse and the signal pulse whose time delay is adjusted on an ionization material, and an ionization yield measurement unit to measure an ionization yield from electrons and/or ions generated by the focused fundamental pulse and signal pulse. The waveform of the input light wave is obtained by obtaining an ionization yield modulation changed by the signal pulse as a function of the time delay.
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公开(公告)号：US10045843B2
公开(公告)日：2018-08-14
申请号：US15055492
申请日：2016-02-26
Inventor： Daehyeong Kim , Taeghwan Hyeon , Jaemin Kim , Mincheol Lee , Hyungjoon Shim
Abstract: A stretchable electronic device for artificial skin and a method of manufacturing the same are disclosed. The stretchable electronic device for artificial skin includes a first encapsulation layer, a heater disposed on the first encapsulation layer, a second encapsulation layer disposed on the heater, a first sensor array layer disposed on the second encapsulation layer, and a third encapsulation layer disposed on the first sensor array layer.
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