公开(公告)号：US06423689B1

公开(公告)日：2002-07-23

申请号：US09212785

申请日：1998-12-16

申请人： Richard John Booth ,  Louis Brogley ,  Wayne Livingston Cody ,  David Thomas Connor ,  Harriet Wall Hamilton ,  John Xiaoqiang He ,  Lain-Yen Hu ,  Leonard Joseph Lescosky ,  Thomas Charles Malone ,  Laszlo Nadasdi ,  Michael Francis Rafferty ,  Bruce David Roth ,  Diego F. Silva ,  Yuntao Song ,  Balazs G. Szoke ,  Laszlo Urge

发明人： Richard John Booth ,  Louis Brogley ,  Wayne Livingston Cody ,  David Thomas Connor ,  Harriet Wall Hamilton ,  John Xiaoqiang He ,  Lain-Yen Hu ,  Leonard Joseph Lescosky ,  Thomas Charles Malone ,  Laszlo Nadasdi ,  Michael Francis Rafferty ,  Bruce David Roth ,  Diego F. Silva ,  Yuntao Song ,  Balazs G. Szoke ,  Laszlo Urge

IPC分类号： A61K3805

CPC分类号： C07K5/06008 ,  A61K38/00

摘要： The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

摘要翻译： 本发明提供了阻断下文所示的式I的钙通道的化合物。本发明还提供了使用式I化合物治疗中风，脑缺血，头部创伤或癫痫的方法以及含有下列化合物的药物组合物： 一级方程式

公开(公告)号：US06379191B1

公开(公告)日：2002-04-30

申请号：US09653481

申请日：2000-09-01

申请人： David Goetz ,  David Roth

发明人： David Goetz ,  David Roth

IPC分类号： H01R2400

CPC分类号： H05K5/0021 ,  H01R12/778 ,  H01R13/20 ,  H01R13/26 ,  H01R13/64 ,  H01R24/86 ,  H01R33/7607 ,  H05K7/1441

摘要： An electrical connector having a connector housing with a first surface with a center portion, the first surface having a circular periphery. A set of contacts disposed around the center portion of the round connector housing and accessible through a set of openings in the first surface of the connector housing.

摘要翻译： 一种具有连接器壳体的电连接器，其具有带有中心部分的第一表面，所述第一表面具有圆形周边。 一组触点，其设置在圆形连接器壳体的中心部分周围并且可通过连接器壳体的第一表面中的一组开口接近。

公开(公告)号：US06348487B1

公开(公告)日：2002-02-19

申请号：US09698342

申请日：2000-10-27

申请人： David Thomas Connor ,  Shelly Ann Glase ,  Terri Stoeber Purchase ,  Bruce David Roth ,  Bharat Kalidas Trivedi

发明人： David Thomas Connor ,  Shelly Ann Glase ,  Terri Stoeber Purchase ,  Bruce David Roth ,  Bharat Kalidas Trivedi

IPC分类号： A61K31405

CPC分类号： C07D235/02 ,  C07D235/18

摘要： Benzimidazole derivatives of Formula I or a pharmaceutically acceptable salt thereof are MCP-1 antagonists and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders wherein A is N or CH; where W, X, Y, and Z can be independently C—R2, C—R3, C—R4, C—R5, or N; no more than two of W, X, Y, and Z can be N in any one structure, R2, R3, R4, and R5 are as define in the specification.

摘要翻译： 式I的苯并咪唑衍生物或其药学上可接受的盐是MCP-1拮抗剂，因此可用于治疗炎症，动脉粥样硬化，再狭窄和免疫疾病，其中A是N或CH;其中W，X，Y和Z可以是 独立地是C-R2，C-R3，C-R4，C-R5或N;在任何一个结构中，W，X，Y和Z中不超过两个可以是N，R2，R3，R4和R5是 如规范中的定义。

公开(公告)号：US06316449B1

公开(公告)日：2001-11-13

申请号：US09558267

申请日：2000-04-25

申请人： Larry Don Bratton ,  Steven Robert Miller ,  Bruce David Roth ,  Bharat Kalidas Trivedi ,  Paul Charles Unangst

发明人： Larry Don Bratton ,  Steven Robert Miller ,  Bruce David Roth ,  Bharat Kalidas Trivedi ,  Paul Charles Unangst

IPC分类号： A61K31150

CPC分类号： C07D471/14

摘要： The instant invention is a series of compounds which are MCP-1 receptor antagonists of Formula I Also included in the invention are intermediates and processes for the preparation of the compounds as well as methods of using the compounds as agents for the treatment of atherosclerosis, chronic and acute inflammatory disease, chronic and acute immune disorders and transplant rejection as well as for preventing infection by HIV, treating infection by HIV, delaying the onset of AIDS, or treating AIDS.

摘要翻译： 本发明是一系列化合物，其是本发明中包括的式IAl的MCP-1受体拮抗剂，其是中间体和化合物的制备方法，以及使用该化合物作为治疗动脉粥样硬化，慢性和 急性炎症性疾病，慢性和急性免疫疾病和移植排斥以及预防艾滋病毒感染，治疗艾滋病毒感染，延迟艾滋病发作或治疗艾滋病。

公开(公告)号：US06316415B1

公开(公告)日：2001-11-13

申请号：US09284422

申请日：1999-04-09

申请人： Hans P. Albrecht ,  Hamish John Allen ,  Kenneth Dale Brady ,  William Glen Harter ,  Catherine Rose Kostlan ,  Bruce David Roth ,  Nigel Walker

发明人： Hans P. Albrecht ,  Hamish John Allen ,  Kenneth Dale Brady ,  William Glen Harter ,  Catherine Rose Kostlan ,  Bruce David Roth ,  Nigel Walker

IPC分类号： A61K3118

CPC分类号： C07K5/1024 ,  A61K38/00 ,  C07C311/06 ,  C07C311/19 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/42 ,  C07C2603/18 ,  C07D217/24 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06104 ,  C07K5/06139 ,  C07K5/0804 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0819 ,  C07K5/0821 ,  C07K5/1005 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021

摘要： The present invention relates to compounds that are inhibitors of interleukin-1&bgr; converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1&bgr; converting enzyme.

摘要翻译： 本发明涉及作为具有式（I）的白细胞介素-1β转换酶的抑制剂的化合物。 本发明还涉及治疗中风，再灌注损伤，阿尔茨海默病，志贺氏菌病，炎性疾病和败血性休克的方法以及含有作为白细胞介素-1β转换酶抑制剂的化合物的药学上可接受的组合物。

公开(公告)号：US06307089B2

公开(公告)日：2001-10-23

申请号：US09736802

申请日：2000-12-14

申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

IPC分类号： C07C6976

CPC分类号： C07C323/63 ,  C07C59/56 ,  C07C59/84 ,  C07C59/88 ,  C07C59/90 ,  C07C69/738 ,  C07C251/48 ,  C07C251/86 ,  C07C255/64

摘要： Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells.

公开(公告)号：US06017918A

公开(公告)日：2000-01-25

申请号：US360556

申请日：1999-07-26

申请人： Helen Tsenwhei Lee ,  Mark Alan Massa ,  William Chester Patt ,  Bruce David Roth

发明人： Helen Tsenwhei Lee ,  Mark Alan Massa ,  William Chester Patt ,  Bruce David Roth

IPC分类号： C07C229/36 ,  C07D213/74 ,  C07D295/145 ,  C07D307/52 ,  C07D317/64 ,  C07D317/66 ,  C07D333/20 ,  A61K31/215 ,  A61K31/535 ,  C07D295/15

CPC分类号： C07D213/74 ,  C07C229/36 ,  C07D295/145 ,  C07D307/52 ,  C07D317/64 ,  C07D317/66 ,  C07D333/20 ,  C07C2101/02 ,  C07C2101/14

摘要： The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.

摘要翻译： 本发明提供具有式I的化合物本发明还提供使用式I化合物治疗动脉粥样硬化，冠心病和再狭窄的方法，以及包含式I化合物的药物组合物。

公开(公告)号：US5981595A

公开(公告)日：1999-11-09

申请号：US85657

申请日：1993-07-01

申请人： Joseph Armand Picard ,  William Howard Roark ,  Bruce David Roth

发明人： Joseph Armand Picard ,  William Howard Roark ,  Bruce David Roth

IPC分类号： C07C311/53 ,  C07C311/55 ,  A61K31/175

CPC分类号： C07C311/53 ,  C07C311/55

摘要： A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; R.sub.1 is hydrogen, lower alkyl or benzyl; and R.sub.2 is a straight or branched alkyl group having from 5 to 17 carbon atoms which may be substituted on the 1-carbon position with methyl, ethyl, phenyl, or substituted phenyl, or a cycloalkyl group having from 3 to 8 carbon atoms.

摘要翻译： 一种降低具有下式的血液胆固醇水平的药学上有用的化合物，其中X是氧或-NH-; Ar是苯基，取代的苯基，萘基或取代的萘基; R1是氢，低级烷基或苄基; 并且R 2是具有5至17个碳原子的直链或支链烷基，其可以在1-碳位上被甲基，乙基，苯基或取代的苯基或具有3至8个碳原子的环烷基取代。

公开(公告)号：US5519669A

公开(公告)日：1996-05-21

申请号：US108268

申请日：1993-08-19

申请人： Paul C. Ross ,  Alex Kononov ,  William W. Plumlee ,  S. David Roth

发明人： Paul C. Ross ,  Alex Kononov ,  William W. Plumlee ,  S. David Roth

IPC分类号： G01S15/02 ,  G01S15/50 ,  G06Q40/00 ,  G08B13/16 ,  G01S15/00

CPC分类号： G06K9/00778 ,  G01S15/02 ,  G01S15/50 ,  G06K9/00369 ,  G07F19/207 ,  G08B13/1636

摘要： Acoustic surveillance of objects and human traffic in a spatial zone of a financial transaction device is used to detect movement within the zone. Several specific types of detected movement defined as abnormal trigger an alert to a remote monitoring station. The alerts are automatically prioritized using rule-based criteria. Enhanced surveillance of the alert site by audio links as well as site alert history information are provided.

摘要翻译： 在金融交易设备的空间区域中对物体和人流量的声学监视用于检测区域内的移动。 被定义为异常的几种特定类型的检测到的移动会触发对远程监控站的警报。 使用基于规则的标准自动优先处理警报。 提供通过音频链接增强对警报站点的监视以及站点警报历史信息。

公开(公告)号：US09959330B2

公开(公告)日：2018-05-01

申请号：US13464897

申请日：2012-05-04

申请人： Rondy Ng ,  Robert Zwiebach ,  David Haimes ,  Djiao Mei Siauw ,  Gregory David Roth ,  Arunesh Banerjee ,  Santosh Kumar Matam ,  Venkata Ramana Murthy Kosuri

发明人： Rondy Ng ,  Robert Zwiebach ,  David Haimes ,  Djiao Mei Siauw ,  Gregory David Roth ,  Arunesh Banerjee ,  Santosh Kumar Matam ,  Venkata Ramana Murthy Kosuri

IPC分类号： G06F17/00 ,  G06F17/30

CPC分类号： G06F17/30563 ,  G06F17/30557 ,  G06F17/30581 ,  G06F17/3087 ,  G06F17/30997

摘要： In an embodiment, for any structural change that is made to a relational database, a corresponding change is also made to the multidimensional database. In an embodiment, the system determines that a particular structure is not implemented on the multidimensional database system. Based on metadata that defines the structure that is supposed to exist in the multidimensional database, the appropriate structure is created.