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公开(公告)号：US06423689B1
公开(公告)日：2002-07-23
申请号：US09212785
申请日：1998-12-16
Applicant: Richard John Booth , Louis Brogley , Wayne Livingston Cody , David Thomas Connor , Harriet Wall Hamilton , John Xiaoqiang He , Lain-Yen Hu , Leonard Joseph Lescosky , Thomas Charles Malone , Laszlo Nadasdi , Michael Francis Rafferty , Bruce David Roth , Diego F. Silva , Yuntao Song , Balazs G. Szoke , Laszlo Urge
Inventor： Richard John Booth , Louis Brogley , Wayne Livingston Cody , David Thomas Connor , Harriet Wall Hamilton , John Xiaoqiang He , Lain-Yen Hu , Leonard Joseph Lescosky , Thomas Charles Malone , Laszlo Nadasdi , Michael Francis Rafferty , Bruce David Roth , Diego F. Silva , Yuntao Song , Balazs G. Szoke , Laszlo Urge
IPC: A61K3805
CPC classification number: C07K5/06008 , A61K38/00
Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
Abstract translation: 本发明提供了阻断下文所示的式I的钙通道的化合物。本发明还提供了使用式I化合物治疗中风，脑缺血，头部创伤或癫痫的方法以及含有下列化合物的药物组合物： 一级方程式
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![2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones](/abs-image/US/2007/04/24/US07208489B2/abs.jpg.150x150.jpg)
公开(公告)号：US07208489B2
公开(公告)日：2007-04-24
申请号：US11046126
申请日：2005-01-28
Applicant: Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
Inventor： Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
IPC: C07D401/14 , A61K31/444
CPC classification number: C07D471/04 , A61K31/519 , A61K31/675
Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4)
Abstract translation: 本发明提供了可用于治疗细胞增殖性疾病的取代的2-氨基吡啶。 本发明的新化合物是细胞周期蛋白依赖性激酶4（cdk4）的有效抑制剂，
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![Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors](/abs-image/US/2006/05/30/US07053070B2/abs.jpg.150x150.jpg)
公开(公告)号：US07053070B2
公开(公告)日：2006-05-30
申请号：US10182178
申请日：2001-01-23
Applicant: Richard John Booth , Ellen Myra Dobrusin , Vara Prasad Venkata Nagendra Josyula , Dennis Joseph Mc Namara , Peter Laurence Toogood
Inventor： Richard John Booth , Ellen Myra Dobrusin , Vara Prasad Venkata Nagendra Josyula , Dennis Joseph Mc Namara , Peter Laurence Toogood
IPC: C07D471/04 , A61K31/519 , A61P35/00 , A61P9/10
CPC classification number: C07D471/04
Abstract: Disclosed are compounds of the formula wherein R2, R5, R6, R7, and R8 are as defined herein. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.
Abstract translation: 公开了下式的化合物其中R 2，R 5，R 6，R 7和R 7， SUP> 8 如本文所定义。 这些化合物及其药物组合物可用于治疗细胞增殖性疾病如癌症和再狭窄。 这些化合物是cdks和生长因子介导的激酶的有效抑制剂。
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公开(公告)号：US06780883B2
公开(公告)日：2004-08-24
申请号：US10021633
申请日：2001-12-12
Applicant: Richard John Booth , Helen Tsenwhei Lee , Jason Keith Pontrello , Randy Ranjee Ramharack , Bruce David Roth
Inventor： Richard John Booth , Helen Tsenwhei Lee , Jason Keith Pontrello , Randy Ranjee Ramharack , Bruce David Roth
IPC: A61K3144
CPC classification number: C07D213/40 , C07D213/75 , C07D215/38 , C07D333/38 , C07D405/12 , C07D409/12
Abstract: The present invention provides compounds having the Formula I The present invention also provides pharmaceutical compositions comprising a compound of Formula I and methods of treatment of atherosclerosis, obesity, restenosis, coronary heart disease, hyperlipoproteinemia, hypercholesterolemia, and hypertriglyceridemia.
Abstract translation: 本发明提供了具有式I的化合物本发明还提供包含式I化合物和治疗动脉粥样硬化，肥胖症，再狭窄，冠心病，高脂蛋白血症，高胆固醇血症和高甘油三酯血症的药物组合物。
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公开(公告)号：US06750217B2
公开(公告)日：2004-06-15
申请号：US10198561
申请日：2002-07-18
Applicant: Stephen Douglas Barrett , Haile Tecle , Richard John Booth
Inventor： Stephen Douglas Barrett , Haile Tecle , Richard John Booth
IPC: A61K31535
CPC classification number: C07C311/39 , C07C2601/02
Abstract: Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
Abstract translation: 其中W是OR1，NR2OR1，NRARB，NR2NRARB或NR2（CH2）2-4NRARB的式（I）的苯磺酰胺和权利要求中定义的其它变量是MEK的抑制剂，并且在治疗增殖性疾病中是有效的 ，癌症，中风，心力衰竭，异种移植排斥，关节炎，囊性纤维化，肝肿大，心脏肥大，阿尔茨海默病，糖尿病并发症，败血性休克和病毒感染。
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Patent Agency Ranking
![2-(pyridin-2-ylamino)-pyrido[2,3, d]pyrimidin-7-ones](/abs-image/US/2008/11/25/US07456168B2/abs.jpg.150x150.jpg)
公开(公告)号：US07456168B2
公开(公告)日：2008-11-25
申请号：US11734200
申请日：2007-04-11
Applicant: Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
Inventor： Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
IPC: A61K31/444
CPC classification number: C07D471/04 , A61K31/519 , A61K31/675
Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).
Abstract translation: 本发明提供了可用于治疗细胞增殖性疾病的取代的2-氨基吡啶。 本发明的新化合物是细胞周期蛋白依赖性激酶4（cdk4）的有效抑制剂。
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公开(公告)号：US07094798B1
公开(公告)日：2006-08-22
申请号：US10424228
申请日：2003-04-25
Applicant: Richard John Booth , Ellen Myra Dobrusin , Alan Kraker , Lorna Helen Mitchell , William Alexander Denny , Jeffrey Bruce Smaill , Andrew Mark Thompson , Florence Oliver Joseph McCarthy , Ho Huat Lee , Brian Desmond Palmer
Inventor： Richard John Booth , Ellen Myra Dobrusin , Alan Kraker , Lorna Helen Mitchell , William Alexander Denny , Jeffrey Bruce Smaill , Andrew Mark Thompson , Florence Oliver Joseph McCarthy , Ho Huat Lee , Brian Desmond Palmer
IPC: A61K31/403 , C07D209/88
CPC classification number: C07D487/04 , C07D209/88 , C07D491/04
Abstract: This invention relates to pyrrolocarbazole derivatives according formula I wherein R1, R2, R7, R8, R9, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1
Abstract translation: 本发明涉及式I的吡咯并咔唑衍生物，其中R 1，R 2，R 7，R 8， R 9，X和Y如说明书中所定义，其中所述衍生物特异性抑制检查点激酶Wee1和Chk1中的一个或两个
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公开(公告)号：US06800656B2
公开(公告)日：2004-10-05
申请号：US10169590
申请日：2002-07-05
Applicant: Richard John Booth , Vara Prasad Venkata Nagendra Josyula , Annette Lynn Meyer , Bruce Allan Steinbaugh
Inventor： Richard John Booth , Vara Prasad Venkata Nagendra Josyula , Annette Lynn Meyer , Bruce Allan Steinbaugh
IPC: C07D30791
CPC classification number: C07D307/91 , C07C211/61 , C07C215/88 , C07C217/94 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/18 , C07C2603/24 , C07D209/88 , C07D211/58 , C07D213/38 , C07D223/22 , C07D279/10 , C07D319/24 , C07D327/08 , C07D333/54 , C07D333/76 , C07D405/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D497/04
Abstract: The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. Wherein: X=O, (CH2)m, S, SO, SO2, NH, NR8; Y=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Z=NH, O, NR8, S, SO, SO2; The remaining substituents are described in the specification.
Abstract translation: 本发明提供了具有抗疱疹病毒抗病毒活性的具有下式的化合物及其药学上可接受的盐：其中X = O，（CH 2）m，S，SO，SO 2，NH，NR 8; Y = O CH 2）m，S，SO，SO 2，NH，NR 8或化学键; Z = NH，O，NR 8，S，SO，SO 2;其余取代基在说明书中描述。
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公开(公告)号：US06440966B1
公开(公告)日：2002-08-27
申请号：US09869639
申请日：2001-07-02
Applicant: Stephen Douglas Barrett , Haile Tecle , Richard John Booth
Inventor： Stephen Douglas Barrett , Haile Tecle , Richard John Booth
IPC: C07D295027
CPC classification number: C07C311/39 , C07C2601/02
Abstract: Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
Abstract translation: 其中W是OR1，NR2OR1，NRARB，NR2NRARB或NR2（CH2）2-4NRARB的式（I）的苯磺酰胺和权利要求中定义的其它变量是MEK的抑制剂，并且在治疗增殖性疾病中是有效的 ，癌症，中风，心力衰竭，异种移植排斥，关节炎，囊性纤维化，肝肿大，心脏肥大，阿尔茨海默病，糖尿病并发症，败血性休克和病毒感染。
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![2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones](/abs-image/US/2005/08/30/US06936612B2/abs.jpg.150x150.jpg)
公开(公告)号：US06936612B2
公开(公告)日：2005-08-30
申请号：US10345778
申请日：2003-01-16
Applicant: Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
Inventor： Mark Barvian , Richard John Booth , John Quin, III , Joseph Thomas Repine , Derek J. Sheehan , Peter Laurence Toogood , Scott Norman Vanderwel , Hairong Zhou
IPC: A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/675 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D471/04 , C07F9/6561 , C07D401/14 , A61K31/444
CPC classification number: C07D471/04 , A61K31/519 , A61K31/675
Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4)
Abstract translation: 本发明提供了可用于治疗细胞增殖性疾病的取代的2-氨基吡啶。 本发明的新化合物是细胞周期蛋白依赖性激酶4（cdk4）的有效抑制剂，
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