摘要:
Compounds of formula (I), or pharmaceutically acceptable salts thereof are provided: ##STR1## in which X.sub.1 --(CH.sub.2).sub.x --X.sub.2 forms a 5-7 membered ring wherein: X.sub.1 is O or S; X.sub.2 is O, S or NR wherein R is hydrogen; x is 1, 2 or 3; R.sub.1 is hydrogen, amino, halo, C.sub.1-6 alkyl, hydroxy or C.sub.1-6 alkoxy; R.sub.2 is hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro, amino or C.sub.1-6 alkylthio; R.sub.3 is hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or amino; R.sub.4 and R.sub.5 are independently hydrogen or C.sub.1-6 alkyl; Y is NH; Z is of sub-formula (a): ##STR2## wherein --(CH.sub.2).sub.n.sup.1 is attached at carbon; and n.sup.1 is 0, 1, 2, 3 or 4; q is 0, 1, 2 or 3; R.sub.a is (CH.sub.2).sub.n.sup.2 --R.sub.7 wherein n.sup.2 is 2 or 3 and R.sub.7 is selected from cyano, hydroxyl, C.sub.1-6 alkoxy, phenoxy, C(O)C.sub.1-6 alkyl, COC.sub.6 H.sub.5, --CONR.sub.8 R.sub.9, NR.sub.8 COR.sub.9, SO.sub.2 NR.sub.8 R.sub.9 or NR.sub.8 SO.sub.2 R.sub.9 wherein R.sub.8 and R.sub.9 are hydrogen or C.sub.1-6 alkyl; and R.sub.6 is hydrogen or C.sub.1-6 alkyl. The present compounds exhibit 5-HT.sub.4 receptor antagonist activity.
摘要翻译:提供式(I)化合物或其药学上可接受的盐:其中X 1 - (CH 2)x -X 2形成5-7元环,其中:X 1是O或S; X 2是O,S或NR,其中R是氢; x为1,2或3; R 1是氢,氨基,卤素,C 1-6烷基,羟基或C 1-6烷氧基; R 2是氢,卤素,C 1-6烷基,C 1-6烷氧基,硝基,氨基或C 1-6烷硫基; R3是氢,卤素,C1-6烷基,C1-6烷氧基或氨基; R4和R5独立地是氢或C1-6烷基; Y是NH; Z是亚式(a):其中 - (CH 2)n1连接在碳上; n1为0,1,2,3或4; q为0,1,2或3; R a是(CH 2)n R 2,其中n 2是2或3,R 7选自氰基,羟基,C 1-6烷氧基,苯氧基,C(O)C 1-6烷基,COC 6 H 5,-CONR 8 R 9,NR 8 COR 9,SO 2 NR 8 R 9或NR 8 SO 2 R 9 R8和R9是氢或C1-6烷基; R6是氢或C1-6烷基。 本发明化合物显示5-HT 4受体拮抗剂活性。
摘要:
A visual conceptual map is displayed on each window of a program for accomplishing a complex task. In the preferred embodiment, the conceptual map includes all of the program's action dialogs and the potential paths between the action dialogs. The action dialog corresponding to the current window, the action dialogs that can presently be selected from the current window, and the other action dialogs are visually distinguished from each other. In addition, the potential paths from the action dialog corresponding to the current window to the action dialogs that may presently be selected from the current window are visually distinguished from the other potential paths.
摘要:
A method and system in a data processing system for providing an intuitive display of scheduling information for multiple users within a single viewport. Each user is associated with scheduled events which may be displayed along a time line within a viewport on a display within the data processing system. Selection regions are determined within the viewport. Selection regions may be associated with scheduled events, users, or user specified time periods along the time line. Scheduling information is associated with each selection region. While a user is continuously selecting one of the selection regions, the scheduling information associated with the selection region being selected by the user is temporarily displayed. Once the user ceases selecting the selection region, the scheduling information disappears.
摘要:
In a method of depositing a transparent electrically conductive metal oxide coating by reactive sputtering onto the surface of a substrate, the substrate is supported, in spaced relationship with a cathode which is to be sputtered, in a vacuum chamber containing an atmosphere comprising an inert gas and a controlled oxygen concentration at a selected total pressure. The substrate is heated prior to sputtering to a selected elevated temperature, and reactive sputtering is caused by applying a selected negative potential relative to the substrate. The oxygen in the atmosphere is provided and maintained at a selected concentration, and the heating of said substrate is controlled during sputtering to maintain the substrate temperature substantially constant at the selected temperature during substrate heating caused by sputtering. The selected values of the oxygen concentration substrate temperature, vacuum chamber pressure, and cathode potential are so chosen that the deposited coating is haze-free, and its specific electrical resistivity lies at or close to the minimum of the curve which is obtained by plotting specific electrical resistivity against oxygen concentration while maintaining the substrate temperature, vacuum chamber pressure and cathode potential all constant at the selected values. Glass articles with stable, transparent and haze-free coatings having acceptable resistance are produced by the method.
摘要:
A substantially uniform, transparent, electrically conducting, metal oxide film (e.g. of indium/tin oxide) can be deposited on to a substrate such as glass of large lateral dimensions, e.g. a windscreen for an aircraft or a land vehicle, by low-pressure reactive sputtering from a cathode of the metal, using an atmosphere of oxygen and another gas or gases (preferably an inert gas) at reduced pressure, by providing access for the sputtering atmosphere to penetrate into the whole of the working space between the cathode and the substrate so as to maintain a substantial degree of uniformity in the oxygen concentration in the working space. Access for the atmosphere may be provided by means of passages extending through the cathode assembly, by dividing the cathode assembly into parallel strips separated by gaps, and the atmosphere may be supplied direct to the working space through such gaps. Relative movement is effected between the cathode assembly and the substrate, e.g. by reciprocating the parallel strips of the divided cathode in the direction perpendicular to their length.
摘要:
The present invention is an anchor for an artificial structure for attracting fish within a body of water. The structure is comprised of a base and has a central attachment post, a central column configured to secure to the attachment post, and a protective plate.
摘要:
The present system provides a method for a group of people, related or otherwise, to record an event on separate recording devices. The video from those recording devices can then be synchronized with each other. After synchronization, a composite movie is automatically generated using extracts from all or some of the video recordings. The composite movie is returned to a mobile device from where it can be shared and broadcast or re-edited inside the device.
摘要:
A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the lower size range and the particles of the intermediate size range are resolved, and a bright-field image frame is captured in which the particles of the intermediate size range and the particles of the upper size range are resolved. Absolute sizes of the particles of the intermediate size range and the particles of the upper size range are determined from the bright-field image frame. Calibrated sizes of the particles of the lower size range are determined from the dark-field image frame by using the particles of the intermediate size range as internal calibration standards.
摘要:
A system for determining the absolute position of a first object with respect to a second object includes a scalar element attached to the first object and a measuring device attached to the second object. The scalar element comprises a series of coded regions. The coded region represents a number designating a position along an axis of the scalar element. The measuring device includes a two-dimensional optical sensor array configured to capture an image of a portion of the scalar element. The system also includes a processor configured to receive the image and determine an absolute position of the first object with respect to the second object based on at least one coded region of the series of coded regions.