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    5-lipoxygenase activating protein (FLAP) inhibitor
    4.
    发明授权
    5-lipoxygenase activating protein (FLAP) inhibitor 失效
    5-脂氧合酶激活蛋白（FLAP）抑制剂

    公开(公告)号：US08697730B2

    公开(公告)日：2014-04-15

    申请号：US12257876

    申请日：2008-10-24

    申请人： Melissa Virginia Rewolinski ,  Kevin Murray Schaab ,  Christopher David King ,  Nicholas Simon Stock

    发明人： Melissa Virginia Rewolinski ,  Kevin Murray Schaab ,  Christopher David King ,  Nicholas Simon Stock

    IPC分类号： A61K31/44 ,  A61K31/405 ,  C07D401/00 ,  C07D209/02

    CPC分类号： C07D401/10 ,  C07D401/14

    摘要： Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal that include, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.

    摘要翻译： 本文描述的是合成3- [5-（吡啶-2-基甲氧基）-3-（2-甲基-2-丙硫基）-1- [4-（2-甲氧基吡啶-5-基）苄基] - 吲哚-2-基] -2,2-二甲基 - 丙酸，其药学上可接受的盐，药学上可接受的溶剂合物。 还描述了适用于哺乳动物的口服给药的药物组合物，以及使用这些口服药物组合物治疗呼吸道疾病或其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。

    BIOACTIVATION OF PARTICLES
    5.
    发明申请
    BIOACTIVATION OF PARTICLES 审中-公开
    颗粒的生物活性

    公开(公告)号：US20120208023A1

    公开(公告)日：2012-08-16

    申请号：US13168399

    申请日：2011-06-24

    申请人： Fabien Pinaud ,  David King ,  Shimon Weiss

    发明人： Fabien Pinaud ,  David King ,  Shimon Weiss

    IPC分类号： C07K14/00 ,  B82Y99/00

    CPC分类号： B82Y30/00 ,  A61K49/0056 ,  A61K49/0067 ,  B82Y5/00 ,  B82Y10/00 ,  Y10T428/2982

    摘要： Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more functional parts. The surface recognition part includes an amino-end and a carboxy-end and is composed of one or more hydrophobic spacers and one or more binding clusters. The functional part(s) is attached to the surface recognition part at the amino-end and/or said carboxy-end.

    摘要翻译： 通过将生物活性肽连接到颗粒表面来生物活化颗粒。 生物活化肽是赋予颗粒一个或多个生物重要功能的基于肽的化合物。 每个生物活化肽包括与颗粒的表面和一个或多个功能部分结合的分子或表面识别部分。 表面识别部分包括氨基末端和羧基末端，并且由一个或多个疏水间隔物和一个或多个结合簇构成。 功能部分在氨基末端和/或所述羧基末端连接到表面识别部分。

    POLICY-BASED MEDIA SYNDICATION AND MONETIZATION
    6.
    发明申请
    POLICY-BASED MEDIA SYNDICATION AND MONETIZATION 审中-公开
    基于政策的媒体协调和手段

    公开(公告)号：US20120016724A1

    公开(公告)日：2012-01-19

    申请号：US13247235

    申请日：2011-09-28

    申请人： Kyle HARRISON ,  David KING ,  Robert ON

    发明人： Kyle HARRISON ,  David KING ,  Robert ON

    IPC分类号： G06Q30/00

    CPC分类号： H04N7/17318 ,  G06Q30/02 ,  G06Q30/0247 ,  G06Q30/0254 ,  G06Q30/0274 ,  H04N21/2541 ,  H04N21/2743

    摘要： Hosted content received from media hosts is used to generate a set of fingerprints representing the hosted content. The fingerprints representing the hosted content are compared to a set of fingerprints representing reference content submitted by content owners to generate one or more match metrics. Based on the match metrics, the media host may provide indication that they accept policy terms specified by the content owners, including revenue sharing terms. If the media host accepts the revenue sharing terms, the media host may provide advertising content to viewers in association with the hosted content matching the reference content. Funds received from providing advertising content are distributed to the media host and the content owner according to the revenue sharing terms.

    摘要翻译： 从媒体主机接收的主机内容用于生成一组代表托管内容的指纹。 将表示托管内容的指纹与表示由内容所有者提交以生成一个或多个匹配度量的参考内容的一组指纹进行比较。 根据比赛指标，媒体主持人可能会提供他们接受内容所有者指定的政策条款的指示，包括收益分享条款。 如果媒体主机接受收益共享条款，则媒体主机可以向与参考内容匹配的托管内容相关联的观众提供广告内容。 从提供广告内容收到的资金根据收入分配条件分发给媒体主持人和内容所有者。

    BINDERS FOR HOLDING LAMINAR OBJECTS
    10.
    发明申请
    BINDERS FOR HOLDING LAMINAR OBJECTS 审中-公开
    用于控制层状物体的粘合剂

    公开(公告)号：US20090175673A1

    公开(公告)日：2009-07-09

    申请号：US12167984

    申请日：2008-07-03

    申请人： Paul Elliott ,  David King ,  David Harbinson

    发明人： Paul Elliott ,  David King ,  David Harbinson

    IPC分类号： B42F13/40

    CPC分类号： B42F13/0013

    摘要： In the field of binders for laminar objects there is a need for a binder which is able to offer a distinctive and unusual appearance,A binder (10), for holding laminar objects (46), comprises a support member (12) which includes at least one binder element (18; 50) to hold one or more laminar objects (46) via respective edges thereof. The support member (12) also includes first and second support elements (34, 36) which are couplable to one another to secure a cover body (25; 100) therebetween. The cover body (28; 100) includes first and second cover elements (14, 16) which extend from either side of the support member (12).

    摘要翻译： 在用于层状物体的粘合剂领域中，需要能够提供独特和不寻常外观的粘合剂。用于保持层状物体（46）的粘合剂（10）包括支撑构件（12），其包括在 至少一个粘合剂元件（18; 50），用于经由其相应边缘保持一个或多个层状物体（46）。 支撑构件（12）还包括第一和第二支撑元件（34,36），第一和第二支撑元件（34,36）可彼此联接以将盖体（25; 100）固定在其间。 盖体（28; 100）包括从支撑构件（12）的任一侧延伸的第一和第二盖元件（14,16）。