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    Persistent gaseous bubbles as ultrasound contrast media
    21.
    发明授权
    Persistent gaseous bubbles as ultrasound contrast media 失效
    持续气泡作为超声造影剂

    公开(公告)号：US5573751A

    公开(公告)日：1996-11-12

    申请号：US361118

    申请日：1994-12-21

    Applicant: Steven C. Quay

    Inventor： Steven C. Quay

    IPC: A61K49/00 ,  A61K49/22 ,  A61K49/02

    CPC classification number: A61K49/223

    Abstract: Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of a microbubble comprised of the gas.

    Abstract translation: 本文公开了用于增强超声图像中的对比度的试剂。 这些试剂是非常小的气泡，或由特殊选择的气体组成的“微泡”。 本文描述的微泡在溶液中显示出长寿命，并且可以以足够小的尺寸产生穿过肺，从而能够改善心血管系统和其他重要器官的超声成像。 本文还公开了用于选择可以从其中产生造影剂的气体的方法。 该方法基于使用气体的固有物理性质的计算，并且描述了将气体的性质与由气体组成的微气泡溶解的时间相关联的手段。

    Imaging tissue sites of inflammation
    22.
    发明授权
    Imaging tissue sites of inflammation 失效
    成像组织部位炎症

    公开(公告)号：US5376356A

    公开(公告)日：1994-12-27

    申请号：US726894

    申请日：1991-07-08

    Applicant: A. Charles Morgan, Jr.

    Inventor： A. Charles Morgan, Jr.

    IPC: A61K49/00 ,  A61K51/04 ,  A61K51/10 ,  A61K51/12 ,  A61K49/02

    CPC classification number: A61K51/1203 ,  A61K49/0004 ,  A61K51/04 ,  A61K51/1093 ,  A61K2123/00

    Abstract: The present invention involves a method of imaging tissue sites of inflammation which takes advantage of the up-regulation of surface antigenic markers on leukocytes upon activation thereof. A recognition agent selected from the group of chemotactic peptides, eosinophilic peptides and agents which are capable of selective interaction with a chemotactic receptor associated with activated leukocytes is radiolabeled. The radiolabeled recognition agent is infused into a patient and the patient's tissue sites are thereafter imaged in order to detect, evaluate or monitor tissue damage mediated by inflammation.

    Abstract translation: 本发明涉及一种成像炎症组织部位的方法，该方法在活化时利用白细胞上表面抗原标志物的上调。 可以放射性标记选自趋化性肽，嗜酸性肽和能够与与活化的白细胞相关的趋化性受体选择性相互作用的试剂组的识别剂。 将放射性标记的识别剂输注入患者，然后将患者的组织部位成像，以便检测，评估或监测炎症介导的组织损伤。

    Methods for technetium/rhenium labeling of proteins
    26.
    发明授权
    Methods for technetium/rhenium labeling of proteins 失效
    蛋白质锝/铼标记方法

    公开(公告)号：US5328679A

    公开(公告)日：1994-07-12

    申请号：US760466

    申请日：1991-09-17

    Applicant: Hans J. Hansen ,  Gary L. Griffiths ,  Anastasia Lentine-Jones

    Inventor： Hans J. Hansen ,  Gary L. Griffiths ,  Anastasia Lentine-Jones

    IPC: A61K51/10 ,  A61K51/12 ,  A61K49/02 ,  A61K39/395 ,  A61K43/00 ,  C07K15/28

    CPC classification number: A61K51/1048 ,  A61K51/10 ,  A61K51/1282 ,  A61K2123/00

    Abstract: A method for radiolabeling a protein with a radioisotope of technetium or rhenium is disclosed which comprises the steps of contacting a solution of a protein containing a plurality of adjacent free sulfhydryl groups, or in particular cases, intact protein containing at least one disulfide group, with stannous ions, and then with radiopertechnetate or radioperrhenate, the amount of stannous ion being sufficient to substantially completely reduce the radiopertechnetate or radioperrhenate, and recovering radiolabeled protein.A rapid and quantitative method for producing a sterile, injectable solution of Tc-99m-labeled monovalent antibody fragment is also disclosed which comprises the step of mixing a sterile solution containing a monovalent antibody fragment having at least one free sulfhydryl group, stannous chloride and excess tartrate, at mildly acidic pH, or a sucrose-stabilized lyophilizate of such solution, with a sterile solution of Tc-99m-pertechnetate, whereby substantially quantitative labeling of the antibody fragment with Tc-99m is effected in about 5 minutes at ambient temperature, the resultant sterile solution of Tc-99m-labeled monovalent antibody fragment being suitable for immediate injection into a patient for scintigraphic imaging.

    Abstract translation: 公开了用锝或铼的放射性同位素放射性标记蛋白质的方法，其包括将含有多个相邻游离巯基的蛋白质溶液或特别是含有至少一个二硫基的完整蛋白质溶液与 亚锡离子，然后用锝铁或无铼酸盐，亚锡离子的量足以基本上完​​全降低玄武岩或无纶珍珠岩，并回收放射性标记的蛋白质。 还公开了用于生产Tc-99m标记的单价抗体片段的无菌注射溶液的快速和定量的方法，其包括将含有至少一个游离巯基，氯化亚锡和过量的一价抗体片段的无菌溶液混合的步骤 用温和酸性pH的酒石酸盐或这种溶液的蔗糖稳定的冻干物，用Tc-99m-高锝酸盐的无菌溶液，由此在约5分钟内在环境温度下对Tc-99m的抗体片段进行基本上定量的标记， 所得到的Tc-99m标记的单价抗体片段的无菌溶液适于立即注射到患者中用于闪烁照相成像。

    Conjugates for tumor localization and/or tumor therapy
    27.
    发明授权
    Conjugates for tumor localization and/or tumor therapy 失效
    用于肿瘤定位和/或肿瘤治疗的结合物

    公开(公告)号：US5308604A

    公开(公告)日：1994-05-03

    申请号：US859273

    申请日：1992-03-26

    Applicant: Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

    Inventor： Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

    IPC: A61K47/48 ,  A61K49/00 ,  A61K51/08 ,  A61K49/02 ,  A61K43/00

    CPC classification number: A61K49/0002 ,  A61K47/48338 ,  A61K47/48715 ,  A61K51/0491 ,  A61K51/08 ,  A61K51/081 ,  A61K51/088 ,  A61K2123/00

    Abstract: The invention relates to conjugates composed ofa) at least one polyalcohol or a derivatized polyalcohol,b) at least one active agent,c) at least one linker andd) a protein,wherein the polyalcohol(s) or the derivatized polyalcohol(s) are polyalcohols or derivatized polyalcohols which are not recognized by the defense system of an organism as exogenous, and the protein is a protein which can be taken up by the tumor specifically or non-specifically, and is not recognized by the defense system of an organism as exogenous. These conjugates are suitable for, on the one hand, making possible a very sensitive method in nuclear medicine for the diagnosis of tumors and, on the other hand, for example also offering new methods for diagnosing tumors in X-ray diagnosis, computerized tomography, nuclear spin tomography, electron spin resonance spectroscopy or electron microscopy.

    Abstract translation: 本发明涉及由a）至少一种多元醇或衍生化多元醇组成的缀合物，b）至少一种活性剂，c）至少一种连接体和d）蛋白质，其中所述多元醇或衍生化多元醇 ）是不被生物体的防御系统识别为外源的多元醇或衍生化多元醇，并且该蛋白质是可被肿瘤特异性或非特异性摄取的蛋白质，并且不被抗体系统识别 有机体为外源性。 这些缀合物一方面适合用于核医学中用于诊断肿瘤的非常敏感的方法，另一方面，例如还提供用于诊断X线诊断，计算机断层扫描， 核自旋断层扫描，电子自旋共振光谱或电子显微镜。

    In vivo brain imaging agent and method for diagnosis of psychiatric disorders
    28.
    发明授权
    In vivo brain imaging agent and method for diagnosis of psychiatric disorders 失效
    体内脑成像剂和精神障碍诊断方法

    公开(公告)号：US5304367A

    公开(公告)日：1994-04-19

    申请号：US614434

    申请日：1990-11-16

    Applicant: Anat Biegon

    Inventor： Anat Biegon

    IPC: A61K51/04 ,  A61K51/12 ,  A61K49/02

    CPC classification number: A61K51/1282 ,  A61K51/0446

    Abstract: A composition useful as an imaging agent comprises a beta adrenergic receptor antagonist compound, preferably iodopindolol, to which is covalently attached an iodine radioisotope such as .sup.123 I or .sup.124 I. This composition is used in a method for radioimaging beta adrenergic receptors in a tissue, preferably brain. In particular, the method is useful with the radioimaging technique of single photon emission computed tomography (SPECT) or positron emission tomography (PET). The above composition, as well as a kit comprising a set of one or more standard radiographic images of beta adrenergic receptors, are also useful in methods for (1) diagnosing an alteration in beta adrenergic receptors in a tissue, particularly brain; (2) diagnosing suicidal depression in a subject; and (3) detecting the therapeutic normalization of beta adrenergic receptor expression in a subject.

    Abstract translation: 可用作显像剂的组合物包含β-肾上腺素能受体拮抗剂化合物，优选碘吲哚洛尔，其共价连接碘放射性同位素如123I或124I。 该组合物用于放射成像的组织，优选脑中的β肾上腺素能受体的方法。 特别地，该方法对于单光子发射计算机断层摄影（SPECT）或正电子发射断层摄影（PET）的放射成像技术是有用的。 上述组合物以及包含一组或多种β肾上腺素能受体的标准放射照相图像的试剂盒也可用于（1）诊断组织，特别是脑中β肾上腺素能受体的改变的方法中; （2）诊断受试者的自杀性抑郁症; 和（3）检测受试者中β肾上腺素能受体表达的治疗正常化。

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