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42 条记录 (耗时 0.013 秒)

    Fatty acid analogues for the treatment of primary and secondary restenosis
    21.
    发明授权
    Fatty acid analogues for the treatment of primary and secondary restenosis 有权
    脂肪酸类似物用于治疗原发性和继发性再狭窄

    公开(公告)号：US06417232B1

    公开(公告)日：2002-07-09

    申请号：US09674982

    申请日：2001-01-08

    申请人： Rolf Berge

    发明人： Rolf Berge

    IPC分类号： A61K3122

    CPC分类号： A61K31/28 ,  A23L33/115 ,  A23L33/12 ,  A61K31/19 ,  A61K31/20 ,  A61K31/215 ,  A61K31/22 ,  A61K31/23 ,  A61K31/255 ,  Y10S514/866

    摘要： The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[Xi—CH2]n—COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1-C4 alkyl, with the proviso that at least one of the Xi is not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.

    摘要翻译： 本发明涉及通式（I）的新型脂肪酸类似物：CH 3 - [CH 2] m - [X 1 -CH 2] n -COOR，其中n为1至12的整数，并且其中m为 0至23，并且其中i是表示相对于COOR的位置的奇数，并且其中彼此独立的Xi选自包含O，S，SO，SO 2，Se和CH 2的基团，并且其中R表示氢或 C1-C4烷基，条件是至少一个X 1不是CH 2，或其盐，前药或复合物，用于制备用于治疗和/或预防原发性和/或继发性狭窄的药物组合物。 此外，本发明涉及所述化合物用于预防和/或治疗由平滑肌细胞的程序性血管创伤和/或病理性增殖引起的疾病和/或血浆高半胱氨酸水平升高的用途。

    Disinfecting composition
    22.
    发明授权
    Disinfecting composition 有权
    消毒组合物

    公开(公告)号：US06414023B1

    公开(公告)日：2002-07-02

    申请号：US09646523

    申请日：2000-10-13

    申请人： Erik Brandsborg ,  Preben Borelli

    发明人： Erik Brandsborg ,  Preben Borelli

    IPC分类号： A61K3122

    CPC分类号： A01N31/04 ,  A61K31/23 ,  A61K2300/00

    摘要： A disinfecting composition includes about 0.01 to 2% by weight 2,4-dichlorobenzyl alcohol, about 0.1 to 10% by weight of glycerylmonolaurate, and about 95 to 99.5 % by weight vehicle such as a mixture of water and alcohol.

    摘要翻译： 消毒组合物包括约0.01至2重量％的2,4-二氯苄醇，约0.1至10重量％的甘油单月桂酸酯和约95至99.5重量％的载体如水和醇的混合物。

    Process for making an enriched mixture of polyunsaturated fatty acid esters
    23.
    发明授权
    Process for making an enriched mixture of polyunsaturated fatty acid esters 有权
    制备多不饱和脂肪酸酯的富集混合物的方法

    公开(公告)号：US06395778B1

    公开(公告)日：2002-05-28

    申请号：US09758973

    申请日：2001-01-11

    申请人： Devanand L. Luthria

    发明人： Devanand L. Luthria

    IPC分类号： A61K3122

    CPC分类号： C11B3/001 ,  C11B1/025 ,  C11B7/0083 ,  C11C3/003

    摘要： This invention is directed to a process for making an enriched mixture comprising a polyunsaturated fatty acid ester having the Formula (V): In one embodiment, this process comprises transesterifying an oil from Schizochytrium sp. with an alcohol in the presence of a base to form a saturated fatty acid ester and the polyunsaturated fatty acid ester (the fatty acid esters are formed from the alcohol and fatty acid residues of at least one glyceride in the oil). Urea is subsequently dissolved in a medium comprising the fatty acid esters to form a medium comprising the fatty acid esters and dissolved urea. This medium is then cooled or concentrated to form (a) a precipitate comprising urea and at least a portion of the saturated fatty acid ester, and (b) a liquid fraction comprising at least most of the polyunsaturated fatty acid ester. Afterward, the precipitate and liquid fraction are separated. In this embodiment, the alcohol is R3—OH, R3 is a hydrocarbyl or a substituted hydrocarbyl, and R4 is a straight chain hydrocarbyl comprising 21 carbon atoms and at least 2 carbon-carbon double bonds.

    摘要翻译： 本发明涉及一种制备富含混合物的方法，所述混合物包含具有式（V）的多不饱和脂肪酸酯：在一个实施方案中，该方法包括将来自裂殖酵母属（Schizochytrium sp。 在碱存在下用醇形成饱和脂肪酸酯，并且多不饱和脂肪酸酯（脂肪酸酯由油中的至少一种甘油酯的醇和脂肪酸残基形成）。 随后将尿素溶解在包含脂肪酸酯的培养基中以形成包含脂肪酸酯和溶解尿素的培养基。 然后将该介质冷却或浓缩以形成（a）包含尿素和至少一部分饱和脂肪酸酯的沉淀物，和（b）包含至少大部分多不饱和脂肪酸酯的液体馏分。 之后，分离沉淀物和液体馏分。 在该实施方案中，醇为R3-OH，R3为烃基或取代烃基，R4为包含21个碳原子和至少2个碳 - 碳双键的直链烃基。

    Treatment of orthostatic hypotension
    24.
    发明授权
    Treatment of orthostatic hypotension 失效
    治疗直立性低血压

    公开(公告)号：US06365632B1

    公开(公告)日：2002-04-02

    申请号：US09527963

    申请日：2000-03-17

    申请人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    发明人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    IPC分类号： A61K3122

    CPC分类号： A61K31/137

    摘要： A compound of formula I or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating orthostatic hypotension.

    摘要翻译： 式I的化合物或其药学上可接受的盐，其中R 1和R 2独立地为H或甲基（例如N，N-二甲基-1- [1-（4-氯苯基）环丁基] -3-甲基丁基胺盐酸盐， 其一水合物的形式）用于治疗直立性低血压。

    Treatment of pulmonary hypertension
    28.
    发明授权
    Treatment of pulmonary hypertension 失效
    治疗肺动脉高压

    公开(公告)号：US06403650B1

    公开(公告)日：2002-06-11

    申请号：US09527815

    申请日：2000-03-17

    申请人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    发明人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    IPC分类号： A61K3122

    CPC分类号： A61K31/137

    摘要： A compound of formula I or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-4chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating pulmonary hypertension, particularly in patients who take certain anorectic medications.

    摘要翻译： 式I化合物或其药学上可接受的盐，其中R 1和R 2独立地为H或甲基（例如N，N-二甲基-1- [1-4氯苯基]环丁基] -3-甲基丁基胺盐酸盐，其任选地为其 一水合物）用于治疗肺动脉高压，特别是在采取某些无痛药物的患者中。

    Treatment of pain
    29.
    发明授权
    Treatment of pain 失效
    治疗疼痛

    公开(公告)号：US06376553B1

    公开(公告)日：2002-04-23

    申请号：US09528036

    申请日：2000-03-17

    申请人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    发明人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    IPC分类号： A61K3122

    CPC分类号： A61K31/137

    摘要： A compound of formula I or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating pain such as low back pain.

    摘要翻译： 式I的化合物或其药学上可接受的盐，其中R 1和R 2独立地为H或甲基（例如N，N-二甲基-1- [1-（4-氯苯基）环丁基] -3-甲基丁基胺盐酸盐， 其一水合物的形式）用于治疗诸如腰痛的疼痛。

    Treatment of hyperactivity disorders
    30.
    发明授权
    Treatment of hyperactivity disorders 失效
    治疗多动障碍

    公开(公告)号：US06372798B1

    公开(公告)日：2002-04-16

    申请号：US09528046

    申请日：2000-03-17

    申请人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    发明人： Carl M. Mendel ,  Timothy B. Seaton ,  Steve P. Weinstein

    IPC分类号： A61K3122

    CPC分类号： A61K31/135

    摘要： A compound of formula I or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating hyperactivity disorders, such as attention deficit hyperactivity disorder and hyperkinetic disorder.

    摘要翻译： 式I的化合物或其药学上可接受的盐，其中R 1和R 2独立地为H或甲基（例如N，N-二甲基-1- [1-（4-氯苯基）环丁基] -3-甲基丁基胺盐酸盐， 其一水合物的形式）用于治疗多动障碍，例如注意缺陷多动障碍和运动障碍。