公开(公告)号：US06395778B1

公开(公告)日：2002-05-28

申请号：US09758973

申请日：2001-01-11

申请人： Devanand L. Luthria

发明人： Devanand L. Luthria

IPC分类号： A61K3122

CPC分类号： C11B3/001 ,  C11B1/025 ,  C11B7/0083 ,  C11C3/003

摘要： This invention is directed to a process for making an enriched mixture comprising a polyunsaturated fatty acid ester having the Formula (V): In one embodiment, this process comprises transesterifying an oil from Schizochytrium sp. with an alcohol in the presence of a base to form a saturated fatty acid ester and the polyunsaturated fatty acid ester (the fatty acid esters are formed from the alcohol and fatty acid residues of at least one glyceride in the oil). Urea is subsequently dissolved in a medium comprising the fatty acid esters to form a medium comprising the fatty acid esters and dissolved urea. This medium is then cooled or concentrated to form (a) a precipitate comprising urea and at least a portion of the saturated fatty acid ester, and (b) a liquid fraction comprising at least most of the polyunsaturated fatty acid ester. Afterward, the precipitate and liquid fraction are separated. In this embodiment, the alcohol is R3—OH, R3 is a hydrocarbyl or a substituted hydrocarbyl, and R4 is a straight chain hydrocarbyl comprising 21 carbon atoms and at least 2 carbon-carbon double bonds.

摘要翻译： 本发明涉及一种制备富含混合物的方法，所述混合物包含具有式（V）的多不饱和脂肪酸酯：在一个实施方案中，该方法包括将来自裂殖酵母属（Schizochytrium sp。 在碱存在下用醇形成饱和脂肪酸酯，并且多不饱和脂肪酸酯（脂肪酸酯由油中的至少一种甘油酯的醇和脂肪酸残基形成）。 随后将尿素溶解在包含脂肪酸酯的培养基中以形成包含脂肪酸酯和溶解尿素的培养基。 然后将该介质冷却或浓缩以形成（a）包含尿素和至少一部分饱和脂肪酸酯的沉淀物，和（b）包含至少大部分多不饱和脂肪酸酯的液体馏分。 之后，分离沉淀物和液体馏分。 在该实施方案中，醇为R3-OH，R3为烃基或取代烃基，R4为包含21个碳原子和至少2个碳 - 碳双键的直链烃基。