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    Antimicrobial composition and methods of use in the treatment of disease
    1.
    发明授权
    Antimicrobial composition and methods of use in the treatment of disease 失效
    抗微生物组合物和用于治疗疾病的方法

    公开(公告)号：US06500861B1

    公开(公告)日：2002-12-31

    申请号：US09644333

    申请日：2000-08-23

    申请人： Michael D. Wider

    发明人： Michael D. Wider

    IPC分类号： A61K3122

    CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K47/12 ,  A61K47/20 ,  Y02A50/402

    摘要： A composition for eliminating an infection in a body space or cavity or on the epidermis of the body of the user is formed from an antimicrobial active agent which is, preferably, a fatty acid or mixture of fatty acids, an organic acid and a hydrotroper solubilizer. This composition in concentrate form can be diluted or admixed with the deionized, pyrogen-free water to form an effective use solution. The active ingredients herein are either UPS or food grade components.

    摘要翻译： 用于消除身体空间或空腔或使用者身体表皮感染的组合物由抗微生物活性剂形成，抗微生物活性剂优选为脂肪酸或脂肪酸混合物，有机酸和加氢促渗剂增溶剂 。 浓缩物形式的这种组合物可以与去离子的无热原水稀释或混合以形成有效的使用溶液。 这里的活性成分是UPS或食品级成分。

    Ethers of o-desmethyl venlafaxine
    3.
    发明授权
    Ethers of o-desmethyl venlafaxine 失效
    去甲基文拉法辛的醚

    公开(公告)号：US06348494B1

    公开(公告)日：2002-02-19

    申请号：US09722193

    申请日：2000-11-21

    申请人： John P. Yardley ,  Magid A. Abou-Gharbia ,  John W. Ullrich

    发明人： John P. Yardley ,  Magid A. Abou-Gharbia ,  John W. Ullrich

    IPC分类号： A61K3122

    CPC分类号： C07C217/64 ,  C07C2601/14

    摘要： This invention provides O-&agr;-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): wherein: the configuration at the steriogenic center (*) may be R, S, or RS (the racemate); wherein radicals R1, R2, R3, R4, and R5 are as defined in the specification; as well as pharmaceutical compositions and methods treating central nervous system disorders.

    摘要翻译： 本发明提供文拉法辛代谢物4- [2-（二甲基氨基-1-（1-羟基环己基）乙基]苯酚（由式（I）表示）的O-α-酰氧基烷基醚：其中：在灭菌中心（*） 可以是R，S或RS（外消旋体）;其中基团R 1，R 2，R 3，R 4和R 5如说明书中所定义;以及治疗中枢神经系统疾病的药物组合物和方法。

    Formulation of valnemulin
    5.
    发明授权
    Formulation of valnemulin 有权
    valnemulin的配方

    公开(公告)号：US06284792B1

    公开(公告)日：2001-09-04

    申请号：US09733477

    申请日：2000-12-08

    申请人： Kurt Koller ,  Franz Schwarz

    发明人： Kurt Koller ,  Franz Schwarz

    IPC分类号： A61K3122

    CPC分类号： A61K9/0019 ,  A61K31/221 ,  A61K47/10 ,  A61K47/12

    摘要： The preparation of an improved galenic delivery form of valnemulin, which is notable for its good tolerance and stability in storage, is described. The new delivery form in question is a non-aqueous or oily injection formulation, which is obtainable by means of in-situ preparation and subsequent stabilisation of the free, relatively unstable base of the active ingredient. A further aspect of the present invention concerns the usage of such an injection formulation in a method of treating infectious diseases in productive livestock or domestic animals.

    摘要翻译： 描述了一种改进的盖仑剂递送形式的valnemulin的制备，其在其储存中的良好耐受性和稳定性方面是显着的。 所述新的递送形式是非水或油性注射制剂，其可通过原位制备和随后稳定活性成分的游离相对不稳定的碱而获得。 本发明的另一方面涉及这种注射制剂在用于治疗生产性家畜或家畜中的感染性疾病的方法中的用途。

    System for stimulating brain plasticity
    6.
    发明授权
    System for stimulating brain plasticity 有权
    刺激大脑可塑性的系统

    公开(公告)号：US06221908B1

    公开(公告)日：2001-04-24

    申请号：US09224510

    申请日：1998-12-31

    申请人： Michael P. Kilgard ,  Michael M. Merzenich

    发明人： Michael P. Kilgard ,  Michael M. Merzenich

    IPC分类号： A61K3122

    CPC分类号： A61N1/36017 ,  A61N1/30 ,  A61N1/36025 ,  A61N1/36082

    摘要： A system for stimulating brain plasticity releases acetylcholine into the learner's brain while the learner is receiving incoming stimuli or performing an activity during the learning process. It is believed that acetylcholine helps the brain in the learning and memorizing process. In one embodiment, the nucleus basalis region of the learner's brain is electrically stimulated to release acetylcholine, thereby aiding the learning and memorizing process. The electrical stimulation advantageously reduces the need for the learner to attach “behavioral importance” and to pay close attention on the incoming stimuli or activity to stimulate the release of acetylcholine. In other embodiments, delivery systems such as microinjection, implanted micro release devices or implanted photo-sensitive release devices may be used to release acetylcholine into the brain to aid the learning process.

    摘要翻译： 用于刺激大脑可塑性的系统将乙酰胆碱释放到学习者的大脑中，同时学习者在学习过程中接收到进入的刺激或进行活动。 据信乙酰胆碱帮助大脑学习和记忆过程。 在一个实施方案中，电刺激学习者脑的基底区以释放乙酰胆碱，从而有助于学习和记忆过程。 电刺激有利地减少了学习者附加“行为重要性”的需要，并且密切注意进入的刺激或活动以刺激乙酰胆碱的释放。 在其他实施方案中，可以使用诸如显微注射，植入的微型释放装置或植入的光敏释放装置等递送系统将乙酰胆碱释放到脑中以帮助学习过程。

    Oil composition
    8.
    发明授权
    Oil composition 有权
    油组成

    公开(公告)号：US06762203B2

    公开(公告)日：2004-07-13

    申请号：US10032493

    申请日：2002-01-02

    申请人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

    发明人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

    IPC分类号： A61K3122

    CPC分类号： C11C3/10 ,  A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23L27/60 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C11C3/06 ,  A23V2250/1868

    摘要： The invention relates to oil composition comprising 0.1 to 59.8% by weight of a triglyceride, 40 to 99.7% by weight of a diglyceride, 0.1 to 10% by weight of a monoglyceride and at most 5% by weight of a free fatty acid, wherein contents of &ohgr;3 type unsaturated acyl groups having at least 20 carbon atoms and monoenoic acyl groups in acyl groups constituting the diglyceride are 15 to 89.5% by weight and 10 to 84.5% by weight, respectively; and oral medicinal compositions and foods comprising such an oil composition. The oil composition effectively develops physiological functions derived from &ohgr;3 type unsaturated fatty acids, such as inhibition of platelet aggregation, and is excellent in effect of facilitating combustion of body fat, oxidation stability, flavor and the like, and also excellent in flowability.

    摘要翻译： 本发明涉及包含0.1至59.8重量％的甘油三酯，40至99.7重量％的甘油二酯，0.1至10重量％的单酸甘油酯和至多5重量％的游离脂肪酸的油组合物，其中 构成甘油二酯的酰基中具有至少20个碳原子的ω3型不饱和酰基和单烯酰基的含量分别为15〜89.5重量％和10〜84.5重量％ 口服药物组合物和包含这样的油组合物的食品。油组合物有效地发展出来自ω-3型不饱和脂肪酸的生理功能，例如抑制血小板聚集，并且有利于促进身体脂肪燃烧，氧化稳定性，风味 并且流动性也优异。

    Conjugated linoleic acid powder
    9.
    发明授权
    Conjugated linoleic acid powder 有权
    共轭亚油酸粉末

    公开(公告)号：US06756405B2

    公开(公告)日：2004-06-29

    申请号：US09836788

    申请日：2001-04-17

    申请人： Duane Fimreite

    发明人： Duane Fimreite

    IPC分类号： A61K3122

    CPC分类号： A61K31/231 ,  A23D9/05 ,  A23K20/158 ,  A23K50/00 ,  A23K50/42 ,  A23K50/45 ,  A23K50/75 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/20 ,  A61K31/23 ,  C11B3/10 ,  C11B3/12 ,  C11C3/02 ,  C11C3/14 ,  A23V2250/1866

    摘要： A powder containing a high amount of conjugated linoleic acid or other oil is provided. The powder contains either triglycerides containing CLA, free fatty acids of CLA, or alkylesters of CLA, or another desired oil. The powder is free flowing and has good organoleptic properties. The powder may be used as a dietary supplement or combined with foodstuffs to form a food product suitable for consumption by animals or humans.

    摘要翻译： 提供含有大量共轭亚油酸或其它油的粉末。 该粉末含有含有CLA的甘油三酸酯，CLA的游离脂肪酸，或CLA的烷基酯或其它所需的油。 粉末自由流动，具有良好的感官特性。 粉末可以用作膳食补充剂或与食品组合以形成适合于动物或人类消费的食品。

    Antimicrobial preservative compositions and methods
    10.
    发明授权
    Antimicrobial preservative compositions and methods 失效
    抗微生物防腐剂组合物和方法

    公开(公告)号：US06638978B1

    公开(公告)日：2003-10-28

    申请号：US08186824

    申请日：1994-01-26

    申请人： Jon J. Kabara

    发明人： Jon J. Kabara

    IPC分类号： A61K3122

    CPC分类号： A61K31/20 ,  A01N37/02 ,  A01N37/12 ,  A23L3/3508 ,  A61K31/19 ,  Y10S514/946 ,  A01N2300/00

    摘要： The present invention discloses an antimicrobial preservative composition and methods of using the same. The antimicrobial preservative composition includes a glycerol fatty acid ester, a binary mixture of fatty acids including a first fatty acid antimicrobial agent selected from fatty acids having about six to about eighteen carbon atoms and a second fatty acid antimicrobial agent selected from fatty acids having about six to about eighteen carbon atoms where the second fatty acid is different from the first fatty acid and a food-grade carrier. Also disclosed is an antimicrobial preservative composition which includes a safe and effective amount of a ethoxylated or propoxylated glycerol fatty acid ester, a binary mixture of fatty acids including a first fatty acid antimicrobial agent selected from this C6 to C18 fatty acids and a second fatty acid antimicrobial agent selected from C6 to C18 fatty acids where the second fatty acid is different from the first fatty acid and a food-grade carrier. Further a method of preserving food compositions, cosmetics, drugs or the like to improve its shelf life is disclosed.

    摘要翻译： 本发明公开了一种抗微生物防腐剂组合物及其使用方法。 抗微生物防腐剂组合物包括甘油脂肪酸酯，脂肪酸的二元混合物，包括选自具有约6至约18个碳原子的脂肪酸的第一种脂肪酸抗微生物剂和选自具有约6至约18个碳原子的脂肪酸的第二种脂肪酸抗微生物剂 至约十八个碳原子，其中第二脂肪酸不同于第一脂肪酸和食品级载体。 还公开了一种抗微生物防腐组合物，其包括安全有效量的乙氧基化或丙氧基化甘油脂肪酸酯，脂肪酸的二元混合物，包括选自该C6-C18脂肪酸的第一种脂肪酸抗微生物剂和第二种脂肪酸 选自C6至C18脂肪酸的抗微生物剂，其中第二种脂肪酸不同于第一种脂肪酸和食品级载体。 此外，还公开了保存食品成分，化妆品，药​​物等以提高其保存期限的方法。