公开(公告)号：US06326401B1

公开(公告)日：2001-12-04

申请号：US09225742

申请日：1999-01-06

Applicant: Jacques Chauveau ,  Pascal Meyer ,  Jacques Barbet ,  Michel Delaage

Inventor： Jacques Chauveau ,  Pascal Meyer ,  Jacques Barbet ,  Michel Delaage

IPC: A61K3122

CPC classification number: A61K47/14 ,  A61K9/0043 ,  A61K9/006 ,  Y10S514/966

Abstract: A liquid pharmaceutical formulation for administration by the oro-mucosal route, comprising at least one non-polypeptidic active substance and less than 5% W/W of capryl caproyl macrogol glycerides, process for its preparation and it uses.

Abstract translation: 用于通过粘膜途径施用的液体药物制剂，其包含至少一种非多肽活性物质和小于5％W / W的辛酸甘油基甘露糖苷，其制备及其用途。

公开(公告)号：US5298491A

公开(公告)日：1994-03-29

申请号：US699027

申请日：1991-05-13

Applicant: Jacques Chauveau ,  Michel Delaage ,  Anne Morel ,  Louis Segu

Inventor： Jacques Chauveau ,  Michel Delaage ,  Anne Morel ,  Louis Segu

IPC: A61K38/00 ,  A61K51/00 ,  C07C213/06 ,  C07C217/56 ,  C07C235/04 ,  C07C239/20 ,  C07D209/14 ,  C07D209/16 ,  C07D233/24 ,  C07K1/113 ,  C07K5/06 ,  C07K14/00 ,  C07K16/00 ,  G01N33/50 ,  G01N33/78 ,  A61K31/405 ,  G01N21/75

CPC classification number: C07D209/16 ,  G01N33/78

Abstract: Derivatives of biologically active molecules containing a primary amine group and a hydroxylated nucleus, and their addition salts with mineral or organic acids, having general formula I:R'R"N--A--B--O--CH.sub.2 --CO--NH--R (I)A=linear or branched C.sub.1 -C.sub.5 alkylene;B=C.sub.4 -C.sub.10 aromatic nucleus with optional heteroatom, or=group --B.sub.1 --X--B.sub.2 --, wherein X=O or C.sub.1 -C.sub.4 alkylene;--NH--R=amine residue or alcohol residue; andR', R"=C.sub.1 -C.sub.5 alkyl, H or hydrophobic radical, and their addition salts with mineral or organic acids, method of preparation, applications, especially to visualization, purification, the preparation of antibodies and the assay of the total hormone, and as drugs, compositions in which they are present and analytical kits.

Abstract translation: 含有伯胺基和羟基化核的生物活性分子的衍生物及其与矿物或有机酸的加成盐，具有通式I：R'R“NABO-CH2-CO-NH-R（I）A =直链或 支链C 1 -C 5亚烷基; B =具有任选杂原子的C 4 -C 10芳族核，或= B 1 -X-B 2 - ，其中X = O或C 1 -C 4亚烷基; -NH-R =胺残基或醇残基; R'，R“= C 1 -C 5烷基，H或疏水基团，以及它们与矿物或有机酸的加成盐，制备方法，应用，特别是可视化，纯化，抗体制备和总激素测定， 以及作为药物，其中存在的组合物和分析试剂盒。