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公开(公告)号：US20170349870A1
公开(公告)日：2017-12-07
申请号：US15521138
申请日：2015-10-22
Applicant: GE Healthcare Bio-Sciences AB
Abstract: A method for regulating parameters of at least two bioreactor bags individually, which bioreactor bags are provided on one and the same rocking part of a bioreactor system. The method includes the steps of: determining an individual weight of the content in each bioreactor bag at different points in time during processing; regulating one or more parameters in each bioreactor bag in dependence of the individual weights.
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公开(公告)号：US20170321180A1
公开(公告)日：2017-11-09
申请号：US15484084
申请日：2017-04-10
Applicant: Battelle Memorial Institute
Inventor： Zia Abdullah , Michael L. Dickens , Micah Paul McCreery , Randy L. Jones , Elvin Ray Beach, III , Jon-David S. Sears , Erin Suzanne Schultz , Stephanie Ann Smith , Paul E. George, II
CPC classification number: C12M29/04 , C12M23/24 , C12M23/34 , C12M23/40 , C12M23/44 , C12M41/00 , C12P3/00
Abstract: Scalable biomaterial-based bioreactors are described. In one embodiment, the bioreactor may comprise perforated plates stacked such that the assembled bioreactor has the necessary manifolds and chambers to transport gas and liquids to a biomaterial contained within the bioreactor, and to remove the reaction products. In another embodiment, single use bioreactors are described. Methods of operating the bioreactors are also described.
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23.发明授权公开(公告)号：US09738861B2
公开(公告)日：2017-08-22
申请号：US14771358
申请日：2014-02-20
Applicant: KYOTO UNIVERSITY , Nipro Corporation
Inventor： Norio Nakatsuji , Yoshihiro Yoshikawa , Masakatsu Takeuchi , Daiki Tateyama
Abstract: A culture system has a culture bag for suspending and culturing pluripotent stem cells in a culture medium; a waste liquid container for storing used culture medium that is connected to the culture bag; a fresh medium container for storing a fresh culture medium that is connected to the culture bag; three-way stopcocks for switching flow channels from the culture bag to the waste liquid container or the fresh culture medium container, etc.; a trap portion for trapping the pluripotent stem cells in the culture medium in the flow toward the waste liquid container side; and a filter portion for subculturing that is formed in fourth and fifth flow channels in parallel to a first flow channel. The first flow channel connects the trap part to the culture bag, and has a mesh by which a cell mass of the pluripotent stem cells can be divided. A pump is used to pump the liquid in the individual flow channels.
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公开(公告)号：US20170198246A1
公开(公告)日：2017-07-13
申请号：US15404899
申请日：2017-01-12
Applicant: Sarfaraz K. Niazi
Inventor： Sarfaraz K. Niazi
CPC classification number: C12M23/28 , C12M23/26 , C12M29/06 , C12M29/20 , C12M29/26 , C12M37/02 , C12M41/00 , C12M41/12 , C12M41/40 , C12M41/48 , C12M47/10 , C12M47/12
Abstract: A multiuse bioreactor that is a single-use bioreactor, a development bioreactor, a commercial manufacturing bioreactor, a batch, a fed-batch, a perfusion and continuous bioreactor, a convective heat bioreactor, a product capture bioreactor, an ISO 9 bioreactor, a eukaryotic bioreactor, a prokaryotic bioreactor, a technology transfer-free bioreactor, and an inexpensive bioreactor is disclosed.
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公开(公告)号：US20170191019A1
公开(公告)日：2017-07-06
申请号：US15320369
申请日：2015-07-08
Applicant: Hitachi High-Technologies Corporation
Inventor： Masako KAWARAI , Akihiro SHIMASE , Sadamitsu ASO , Toshinari SAKURAI , Eiichiro TAKADA , Kazumichi IMAI
CPC classification number: C12M33/00 , C12M29/00 , C12M41/00 , C12M41/36 , C12M41/48 , C12Q1/02 , G01N15/06 , G01N21/47 , G01N21/51 , G01N21/53 , G01N21/59 , G01N2015/0053 , G01N2015/0065 , G01N2015/0693 , G01N2201/12
Abstract: The present invention addresses the problem of providing: a cell dispersion measurement mechanism whereby it becomes possible to fully disperse cells regardless of the experiences of operators skilled in cell culture and it also becomes possible to determine the number or concentration of cells accurately; a cell culture apparatus equipped with the cell dispersion measurement mechanism; and a cell dispersion measurement method. The problem can be solved by circulating a cell suspension in a flow path to disperse cell masses contained in the cell suspension, and then determining over time the number or concentration of cells and/or the degree of dispersion of cells in the cell suspension that is flowing in the circulation flow path.
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Patent Agency Ranking
公开(公告)号：US20170145371A1
公开(公告)日：2017-05-25
申请号：US15215455
申请日：2016-07-20
Inventor： Yun Jeong SONG , Hwi Gang KIM , Jung Wook SUH , Eun Chang CHOI , Chang Hyuk HONG , Dae Sik KIM , Hyung Soo LEE
Abstract: An embodiment of the present invention provides an apparatus and method for expanding skin capable of expanding autologous skin to the maximum extent and performing a tissue culture of skin at the outside of the body. While an apparatus for expanding autologous skin of body's outside in general takes a form of expanding skin by applying a certain amount of constant force for a period of time regardless of the skin properties, the apparatus and method for expanding skin according to the embodiment of the present invention expands the skin to the maximum extent without rupturing the skin based on measurements of elasticity of the skin to find the maximum expanded area reachable just before rupturing of the skin.
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公开(公告)号：US20170137768A1
公开(公告)日：2017-05-18
申请号：US15360457
申请日：2016-11-23
Inventor： Joseph Cuiffi , Jeffrey T. Borenstein , Anilkumar Harapanahalli Achyuta , Mark J. Mescher , Linda Griffith , Samuel Walker Inman
CPC classification number: C12M23/44 , C12M21/08 , C12M23/12 , C12M23/42 , C12M23/48 , C12M23/58 , C12M29/00 , C12M41/00 , C12M41/44 , C12M41/48 , G01N33/5008
Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.
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公开(公告)号：US09605239B2
公开(公告)日：2017-03-28
申请号：US13515547
申请日：2010-12-15
Applicant: Hanno Ehring , Kine Frej , Owe Salven , Anders Wilen
Inventor： Hanno Ehring , Kine Frej , Owe Salven , Anders Wilen
Abstract: An attachment arrangement for providing a sensor in a flexible bag, said attachment arrangement comprising: a sensor holding part adapted to be integrated with the flexible bag and comprising first locking part protruding out form the flexible bag, the sensor holding part holding an optical sensor inside the flexible bag; an adaptor part provided outside the flexible bag and adapted to hold an optical fiber, the adaptor part comprising second locking part adapted to mate with the first locking part to lock the first locking part and the second locking part together such that the optical fiber can communicate with the optical sensor inside the bag.
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公开(公告)号：US09587211B2
公开(公告)日：2017-03-07
申请号：US13452442
申请日：2012-04-20
Applicant: Wayne L. Johnson , Steven T. Fink
Inventor： Wayne L. Johnson , Steven T. Fink
CPC classification number: C12M21/02 , C12M27/20 , C12M31/10 , C12M41/00 , C12M41/10 , C12M41/26 , C12M41/32 , C12M41/36 , C12M43/02
Abstract: A photo-bioreactor system for growing and harvesting photosynthetic organisms includes an interior space partitioned into a plurality of independently controlled reactor cells, each stepped downward along a slope from a first elevation to a second elevation, and a light source coupled to each reactor cell and configured to illuminate the photosynthetic organisms with first and second light-emitting surfaces. The system includes a fluid circulation system coupled to the reactor container and configured to force a continuous flow of fluid through the cell passages.
Abstract translation: 用于生长和收获光合生物的光生物反应器系统包括分隔成多个独立控制的反应器单元的内部空间，每个反应器单元沿着从第一高度到第二高度的斜坡逐步向下，以及耦合到每个反应器单元的光源， 被配置为用第一和第二发光表面照射光合生物。 该系统包括流体循环系统，其耦合到反应器容器并且构造成迫使流体连续流过细胞通道。
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公开(公告)号：US20160376540A1
公开(公告)日：2016-12-29
申请号：US15195342
申请日：2016-06-28
Applicant: NIKON CORPORATION
Inventor： Yasujiro KIYOTA
CPC classification number: C12M41/14 , C12M23/50 , C12M41/00 , C12M41/36 , C12M41/44 , C12M41/46 , C12M41/48
Abstract: An incubation apparatus, including a temperature-controlled room adjusted to be a predetermined environment condition, and incubating a sample of an incubation container inside the temperature-controlled room, includes a carrying apparatus, an imaging section, and an image analyzing section. The carrying apparatus carries the incubation container in the temperature-controlled room. The imaging section photographs a whole of the incubation container inside the temperature-controlled room. The image analyzing section analyses an operation state of the incubation apparatus or an incubating environment state of the sample based on a total observing image of the incubation container photographed at the imaging section, and outputs an error signal notifying an abnormality of the operation state or the incubating environment state in accordance with the analysis result.
Abstract translation: 包括调节为预定环境条件的温度控制室和在温度控制室内孵育孵育容器的样品的培养装置包括携带装置，成像部分和图像分析部分。 携带装置在温度控制室内携带培养容器。 成像部分将温室内的整个孵化容器拍摄。 图像分析部基于在摄像部拍摄的孵育容器的全部观察图像，分析培养装置的动作状态或样本的孵育环境状态，并输出通知操作状态异常的误差信号或 根据分析结果孵化环境状态。
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