公开(公告)号：US20240101643A1

公开(公告)日：2024-03-28

申请号：US18318487

申请日：2023-05-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Roberto FALKENSTEIN ,  Heiko WALCH ,  Sebastian MALIK ,  Marco THOMANN ,  Matthias FREIHERR VON ROMAN ,  Ingrid GRUNERT ,  Roland DORN ,  Michael HINGAR

IPC: C07K16/00 ,  C07K1/22 ,  C12P21/00

CPC classification number: C07K16/00 ,  C07K1/22 ,  C12P21/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55

Abstract: Herein is reported a method for producing an antibody comprising the steps of forming an antibody-antibody light chain affinity ligand complex, wherein the antibody light chain affinity ligand is immobilized on a solid phase, by applying a solution comprising the antibody to the immobilized antibody light chain affinity ligand, and incubating the complex formed in the previous step with one or more enzymes to modify the glycosylation of the antibody, thereby producing the antibody.

公开(公告)号：US11911441B2

公开(公告)日：2024-02-27

申请号：US15734957

申请日：2019-06-03

Applicant: ONCOIMMUNE, INC. ,  UNIVERSITY OF MARYLAND, BALTIMORE

Inventor： Yang Liu ,  Pan Zheng ,  Martin Devenport

IPC: A61K39/00 ,  A61K38/00 ,  A61P35/02 ,  A61K38/16 ,  A61K38/17 ,  A61P37/06 ,  A61P1/04 ,  C07K14/705 ,  C07K16/42 ,  A61K35/02

CPC classification number: A61K38/177 ,  A61K35/02 ,  A61K39/001129 ,  A61P1/04 ,  A61P37/06 ,  C07K14/70596 ,  C07K16/4241 ,  A61K2039/545 ,  C07K2317/41 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/53 ,  C07K2319/30

Abstract: The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity.

公开(公告)号：US20240060988A1

公开(公告)日：2024-02-22

申请号：US18278571

申请日：2022-02-24

Applicant: DR. REDDY’S LABORATORIES LIMITED

Inventor： Rajiv Pranesh BHARADWAJ ,  Murali JAYARAMAN ,  Sakthi CHANDINI D ,  Aishwarya NATARAJAN ,  Aakash CHANDRAMOULI

IPC: G01N33/68 ,  C07K16/24

CPC classification number: G01N33/6854 ,  C07K16/244 ,  G01N2440/36 ,  G01N2440/34 ,  C07K2317/41

Abstract: The free thiol group present in free cysteines in recombinant therapeutic antibodies are reactive to process components and generates product variants during early stages of biosimilar development. Free thiol group present on the structural motifs, especially in the complementary determining regions (CDR), support maximal antigen binding capability. Product variants associated with these free thiol groups are detrimental for safety and efficacy of these therapeutic antibodies. Methods to identify and characterize various thiol variants an antibody composition is provided and an anti-IL-17A IgG1 composition having these thiol variants are described.

公开(公告)号：US20240052034A1

公开(公告)日：2024-02-15

申请号：US18021272

申请日：2021-08-19

Applicant: PANDION OPERATIONS, INC.

Inventor： Nathan HIGGINSON-SCOTT ,  Kevin Lewis OTIPOBY ,  Joanne L. VINEY ,  Salvatore ALIOTO ,  Lindsay J. EDWARDS

IPC: C07K16/28 ,  A61P37/06

CPC classification number: C07K16/2818 ,  A61P37/06 ,  C07K2317/33 ,  C07K2317/64 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2317/41 ,  C07K2317/73 ,  A61K2039/505

Abstract: Multi-paratopic polypeptides that can be used, for example, to modulate the activity of PD-1.

公开(公告)号：US11897939B2

公开(公告)日：2024-02-13

申请号：US17066874

申请日：2020-10-09

Applicant: The University of North Carolina at Chapel Hill ,  The Johns Hopkins University

Inventor： Samuel Lai ,  Ying-Ying Wang ,  Arthi Kannan ,  Kenetta Nunn ,  Durai Babu Subramani ,  Richard Cone ,  Bing Yang ,  Justin Mccallen

IPC: C07K16/08 ,  A61P31/22 ,  C07K16/10 ,  A61P31/14 ,  C07K16/12 ,  A61P11/00 ,  A61P31/12 ,  A61K39/00

CPC classification number: C07K16/087 ,  A61P11/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/22 ,  C07K16/10 ,  C07K16/1027 ,  C07K16/1214 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/13 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/76

Abstract: The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.

公开(公告)号：US20240043501A1

公开(公告)日：2024-02-08

申请号：US18031691

申请日：2021-10-14

Applicant: AMGEN INC.

Inventor： Alla POLOZOVA ,  Chendi NIU ,  Ramsey A. SALEEM ,  Sreekanth SURAVAJJALA

IPC: C07K16/00 ,  C07K1/16

CPC classification number: C07K16/00 ,  C07K1/16 ,  C07K2317/14 ,  C07K2317/41 ,  C07K2317/732

Abstract: Provided herein are methods of producing an antibody composition comprising determining the relative unpaired afucosylated glycan content and/or the relative unpaired high mannose glycan content of a sample of the antibody composition and selecting the antibody composition for downstream processing based on the relative unpaired afucosylated glycan content and/or relative unpaired high mannose glycan content and/or the ADCC level of the antibody composition. Related methods of determining the relative unpaired glycan content of an antibody composition and methods of modifying the ADCC level of an antibody composition are provided herein.

公开(公告)号：US20240034816A1

公开(公告)日：2024-02-01

申请号：US18469947

申请日：2023-09-19

Applicant: SANOFI ,  INNATE PHARMA

Inventor： Nicolas GOURDIN ,  Laurent GAUTHIER ,  Alexandre TANG ,  Marielle CHIRON ,  Angela VIRONE-ODDOS ,  Alessandro MASIERO ,  Jochen BENINGA ,  Ingo FOCKEN ,  Sambasiva RAO ,  Yanfeng ZHOU ,  Leila SEVIGNY

IPC: C07K16/46 ,  C12N15/63 ,  A61P35/00

CPC classification number: C07K16/468 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/41 ,  C07K2317/14 ,  C07K2317/31

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor.
The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

公开(公告)号：US20240026035A1

公开(公告)日：2024-01-25

申请号：US18256917

申请日：2021-12-13

Applicant: VANDERBILT UNIVERSITY

Inventor： Scott A. SMITH

IPC: C07K16/44 ,  G01N33/53 ,  A61P37/08 ,  G01N33/68 ,  A61K39/35

CPC classification number: C07K16/44 ,  G01N33/5308 ,  A61P37/08 ,  G01N33/6854 ,  A61K39/35 ,  G01N2800/24 ,  G01N2400/00 ,  C07K2317/52 ,  C07K2317/72 ,  C07K2317/41 ,  C07K2317/94 ,  A61K2039/577

Abstract: The present disclosure is directed to human IgE antibodies and fragments thereof binding to galactose-α-1, 3-galactose, a known red meat allergen, and methods for use thereof.

公开(公告)号：US11872215B2

公开(公告)日：2024-01-16

申请号：US17155663

申请日：2021-01-22

Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

Inventor： Geert-Jan Boons

IPC: C07K16/00 ,  A61K31/4188 ,  C07K16/28 ,  A61K47/68 ,  A61K49/00

CPC classification number: A61K31/4188 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K49/0043 ,  A61K49/0058 ,  C07K16/00 ,  C07K16/2803 ,  C07K2317/41 ,  C07K2317/92

Abstract: Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.

公开(公告)号：US11866514B2

公开(公告)日：2024-01-09

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce I. Meesters ,  Ewald T. J. Van Den Bremer ,  Joost J. Neijssen ,  Patrick Van Berkel ,  Bart De Goeij ,  Tom Vink ,  Jan Van De Winkel ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/468 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.