公开(公告)号：US10073036B2

公开(公告)日：2018-09-11

申请号：US15341418

申请日：2016-11-02

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  Thomas A. Klausing ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico

IPC: G01N21/64 ,  G01N21/03 ,  G01N35/02 ,  B01L3/00 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1844 ,  C12M41/36 ,  G01N21/0303 ,  G01N21/0332 ,  G01N35/026 ,  G01N2021/0382 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449 ,  G01N2201/0633

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

公开(公告)号：US10071380B2

公开(公告)日：2018-09-11

申请号：US15887221

申请日：2018-02-02

Applicant: Roche Diabetes Care, Inc.

Inventor： Frank A. Chan

IPC: B65D25/10 ,  B65D25/02 ,  B01L9/00 ,  B01L99/00 ,  B01L3/00 ,  G01N33/487 ,  A61B50/30

CPC classification number: B01L9/52 ,  A61B50/30 ,  B01L3/508 ,  B01L99/00 ,  B01L2200/022 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0825 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0858 ,  G01N33/48778

Abstract: A component for a storage container configured to receive vertically oriented articles. The component includes a tubular sidewall extending longitudinally from a base, and at least one spacer portion extending from an underside of the base and configured for engagement with an interior surface of a corresponding storage container. The component also includes at least one pair of retainer elements extending laterally from an inner surface of the tubular sidewall and inwardly into an interior region of the component, and with the retainer elements being oppositely oriented and configured to retain a vertically oriented article therebetween by frictional engagement with opposite longitudinal edges of the article, and wherein an insertion force for resilient deflection of the retainer elements during insertion of the article is less than a removal force for resilient deflection of the retainer elements during removal of the article.

公开(公告)号：US10047331B2

公开(公告)日：2018-08-14

申请号：US14772663

申请日：2014-03-13

Applicant: UNISENSE FERTILITECH A/S

Inventor： Jonas Lerche Hansen ,  Niels B. Ramsing ,  Søren Porsgaard ,  Holger Søe Plougsgaard ,  Mai Faurschou Isaksen

IPC: C12M1/34 ,  C12M3/00 ,  C12M1/32 ,  B01L3/00 ,  C12M1/00 ,  G01N33/50

CPC classification number: C12M23/12 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  C12M21/06 ,  C12M23/02 ,  C12M41/36 ,  G01N33/5005

Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.

公开(公告)号：US10041865B2

公开(公告)日：2018-08-07

申请号：US15874789

申请日：2018-01-18

Applicant: Lions VisionGift

Inventor： Khoa D. Tran

IPC: G01N1/28 ,  G01N21/03 ,  G01N15/10 ,  G01N15/14

CPC classification number: G01N1/28 ,  A61F2/0095 ,  A61F2/142 ,  B01L3/508 ,  B01L2200/185 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0851 ,  C12N5/0621 ,  C12N5/0693 ,  C12N5/0697 ,  C12N2529/10 ,  G01N15/10 ,  G01N21/03 ,  G01N21/4795 ,  G01N21/55 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2021/0342

Abstract: Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assemblies may include a viewing chamber and a corneal tissue carrier removably coupled to an inner portion of the viewing chamber. The assemblies may further include a corneal tissue sample disposed within the corneal tissue carrier. Methods of processing a corneal tissue sample and administering the corneal tissue sample to a subject are also provided.

公开(公告)号：US20180214872A1

公开(公告)日：2018-08-02

申请号：US15938514

申请日：2018-03-28

Applicant: Qiagen Sciences, LLC

Inventor： Thomas Daniel Perroud ,  Michel Georges Perbost

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L7/52 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2300/168 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/049 ,  G01N1/2813 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6458 ,  G02B21/34

Abstract: A sequencing instrument including a sequencing stage and a microscope. The sequencing stage has a reference plate with a flat reference surface. The microscope optical axis is perpendicular to the reference surface. The sequencing stage is configured to receive a flexible film having a plurality of DNA templates immobilized on a first side of the film, and to hold the flexible film against the flat reference surface with at least some of the plurality of DNA templates in an object plane that is perpendicular to the microscope's optical axis.

公开(公告)号：US20180200713A1

公开(公告)日：2018-07-19

申请号：US15743852

申请日：2016-08-11

Applicant: Shenyang Medical College

Inventor： Shaoheng He

IPC: B01L3/00

CPC classification number: B01L3/50855 ,  B01L3/502 ,  B01L3/5088 ,  B01L2200/028 ,  B01L2300/0609 ,  B01L2300/0825 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/168

Abstract: A freely-assembled ELISA plate is provided, including a first ELISA plate frame, a second ELISA plate frame, and ELISA plate strips located between the first ELISA plate frame and the second ELISA plate frame, collectively forming a liquid flow groove. The first ELISA plate frame is connected to a first side of the ELISA plate strips. A second side of the ELISA strips is connected to the second ELISA plate frame. The number of the ELISA plate strips in the ELISA plate can be determined according to the sample size, so that the waste of well resources of the ELISA plate can be effectively reduced; and, a desired amount of samples, washing buffer or the like can be added into the liquid flow groove once for all, so that the sample loading amount can be reduced and the detection speed can be quickened.

公开(公告)号：US20180185772A1

公开(公告)日：2018-07-05

申请号：US15739520

申请日：2016-06-21

Applicant: Marko Karhiniemi ,  Mika Karilahti ,  Medigoo Oy

Inventor： Marko Karhiniemi ,  Mika Karilahti

IPC: B01D21/26 ,  B01L3/00 ,  B04B1/02 ,  B04B5/04 ,  B04B7/08 ,  B04B9/04 ,  G01N33/49

CPC classification number: B01D21/262 ,  B01D21/26 ,  B01L3/5021 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/123 ,  B04B1/02 ,  B04B5/0407 ,  B04B7/08 ,  B04B9/04 ,  G01N33/491

Abstract: The invention relates generally to health tests and needs to examine bodily fluids such as blood. The invention comprises a centrifuge and system for a bodily fluid sample. The centrifuge comprises a sample chamber for receiving the bodily fluid sample through an opening so that the bodily fluid sample rests against an inner surface of the sample chamber. The centrifuge further comprises a contact part for coupling the sample chamber to an actuator, the actuator being configured to rotate the sample chamber and cause sedimentation of the bodily fluid sample.

公开(公告)号：US20180171377A1

公开(公告)日：2018-06-21

申请号：US15385799

申请日：2016-12-20

Applicant: Lawrence Livermore National Security, LLC

Inventor： Melinda Simon ,  N. Reginald Beer

IPC: C12Q1/24 ,  B01L3/00

CPC classification number: C12Q1/24 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2400/086

Abstract: Techniques, systems, and devices are described for implementing a droplet array for single-cell analysis. A method of conducting single-cell analysis comprises generating a plurality of droplets, wherein each of the plurality of droplets contains a core material surrounded by a protective shell; loading the plurality of droplets, via a carrying fluid, onto an array including a plurality of trap structures, wherein the plurality of droplets are held by the plurality of trap structures; selecting a target droplet, held by a trap structure, from the plurality of droplets; and releasing the target droplet from the trap structure.

公开(公告)号：US09989494B2

公开(公告)日：2018-06-05

申请号：US14621702

申请日：2015-02-13

Applicant: ARKRAY, INC.

Inventor： Naotsugu Onuma

IPC: G01N27/447 ,  B32B38/00 ,  B32B37/12 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/16 ,  B01L2400/0421 ,  B29C65/08 ,  B29C65/18 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/919 ,  B29C66/929 ,  B29C66/949 ,  B29L2031/756 ,  B32B37/12 ,  B32B38/0008 ,  B32B2037/243 ,  B32B2310/0481 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00206 ,  B29K2033/12 ,  B29K2069/00 ,  B29K2027/06 ,  B29K2023/38 ,  B29K2071/00 ,  B29K2025/06 ,  B29K2027/18 ,  B29K2023/12 ,  B29K2023/06

Abstract: A method for manufacturing a chip that includes a microchannel is described, wherein the method includes the steps of: fixing a cationic polymer having a quaternary onium group to at least one surface of each of a pair of resin substrates; and joining the resin substrates together on the surfaces on which the cationic polymer has been fixed.

公开(公告)号：US09975125B2

公开(公告)日：2018-05-22

申请号：US15464650

申请日：2017-03-21

Applicant: VyCAP B.V.

Inventor： Arjan Gerhardus Johannes Tibbe ,  Cornelis Johannes Maria van Rijn ,  Leonardus Wendelinus Mathias Marie Terstappen

IPC: G01N1/00 ,  B01L3/00

CPC classification number: B01L3/5085 ,  B01L3/502 ,  B01L2200/0668 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0893 ,  B01L2300/161

Abstract: A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.