公开(公告)号：US20180028661A1

公开(公告)日：2018-02-01

申请号：US15529488

申请日：2015-11-21

申请人： UNIVERSIDAD DE GRANADA ,  SERVICIO ANDALUZ DE SALUD ,  UNIVERSIDAD NACIONAL DE CÓRDOBA

发明人： Modesto Torcuato LÓPEZ LÓPEZ ,  Juan de Dios GARCÍA LÓPEZ-DURÁN ,  Miguel ALAMINOS MINGORANCE ,  Ismael Ángel RODRÍGUEZ ,  Giuseppe SCIONTI

IPC分类号： A61K47/02 ,  C12N5/077 ,  A61K9/50 ,  A61K35/33

CPC分类号： A61K47/02 ,  A61F2/00 ,  A61F2/02 ,  A61K9/5026 ,  A61K35/33 ,  A61L27/042 ,  A61L27/34 ,  A61L27/50 ,  A61L2300/44 ,  A61L2400/12 ,  C12N5/00 ,  C12N5/0656 ,  C12N2501/998 ,  C12N2501/999 ,  C08L33/08

摘要： The invention is comprised in the field of biomedicine, and more specifically, the field of tissue engineering. The invention specifically relates to the use of multiple magnetic domain particles that have a mean diameter greater than 25 nm, to compositions and biomaterials comprising same, and to an in vitro method for producing an artificial tissue with the magnetic particles, to the artificial tissue that can be produced by said method, and to the use of said artificial tissue for partially or completely increasing, restoring or replacing the functional activity of a damaged organ or tissue.

公开(公告)号：US09877822B2

公开(公告)日：2018-01-30

申请号：US13869949

申请日：2013-04-24

申请人： Biostage, Inc.

发明人： Thomas Grosse

IPC分类号： A61F2/02 ,  A61F2/04 ,  C12M3/00 ,  C12N5/00 ,  C12M1/12 ,  A61F2/20

CPC分类号： A61F2/02 ,  A61F2/04 ,  A61F2/20 ,  A61F2002/043 ,  A61F2002/046 ,  A61F2240/004 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0068 ,  F04C2270/041

摘要： According to some aspects, supports are provided for producing artificial tissue scaffolds.

公开(公告)号：US20180008391A1

公开(公告)日：2018-01-11

申请号：US15204517

申请日：2016-07-07

申请人： Collagen Matrix, Inc.

发明人： Shu-Tung Li ,  Natsuyo Shishido Lee ,  Debbie Yuen

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61L27/48 ,  A61L27/26 ,  A61L27/24

CPC分类号： A61F2/0077 ,  A61F2/02 ,  A61F2/10 ,  A61F2002/009 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/56 ,  A61L27/60 ,  A61L2430/34

摘要： A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.

公开(公告)号：US20180008328A1

公开(公告)日：2018-01-11

申请号：US15711452

申请日：2017-09-21

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

发明人： Michele Viola Manuel ,  James F. Schumacher ,  Emily Hester ,  Daniella C. van der Merwe

IPC分类号： A61B17/86 ,  A61F2/02 ,  A61C8/00 ,  A61B17/00

CPC分类号： A61B17/8605 ,  A61B2017/00526 ,  A61C8/0012 ,  A61C8/0022 ,  A61C8/0074 ,  A61F2/02 ,  A61F2210/0004

摘要： Disclosed herein is an article comprising a first screw and a second screw, the first screw being reversibly attached to the second screw such that a longitudinal axis of the first screw coincides with or is parallel to a longitudinal axis of the second screw; the first screw and the second screw each comprising a biodegradable composition, the biodegradable composition comprising a metal or metal alloy comprising magnesium, strontium, zinc, calcium or a combination comprising at least one of the foregoing. Methods of making and using the article are also disclosed herein.

公开(公告)号：US09861465B2

公开(公告)日：2018-01-09

申请号：US13825540

申请日：2011-09-22

申请人： Lay Poh Tan ,  Philip Wong ,  Yin Chiang Freddy Boey ,  Subbu Venkatraman

发明人： Lay Poh Tan ,  Philip Wong ,  Yin Chiang Freddy Boey ,  Subbu Venkatraman

IPC分类号： A61F2/02 ,  A61L27/38 ,  A61L27/44 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61F2/02 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/44 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/62 ,  A61L2300/64 ,  A61L2400/18 ,  C08L67/04

摘要： The present invention relates to a method for forming a tissue construct having a composite structure. The method includes providing a biodegradable substrate, wherein the substrate is adapted to allow deposition or growth of a plurality of cells; providing a vascularized layer comprising a plurality of blood vessels therein; and adhering the vascularized layer to the substrate.

公开(公告)号：US09855709B2

公开(公告)日：2018-01-02

申请号：US15405477

申请日：2017-01-13

申请人： Vertera, Inc.

发明人： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC分类号： B29C67/20 ,  C08J9/32 ,  A61F2/32 ,  A61F2/38 ,  A61F2/30 ,  B29K71/00 ,  B29K105/04

CPC分类号： B29C67/202 ,  A61F2/02 ,  A61F2/32 ,  A61F2/38 ,  A61F2002/30065 ,  A61F2002/30316 ,  A61F2210/0076 ,  A61F2240/001 ,  B29K2071/00 ,  B29K2105/04 ,  C08J9/0085 ,  C08J9/26 ,  C08J9/32 ,  C08J2201/0446 ,  C08J2361/16 ,  C08J2371/00

摘要： A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

公开(公告)号：US09848971B2

公开(公告)日：2017-12-26

申请号：US14611360

申请日：2015-02-02

申请人： ATRIUM MEDICAL CORPORATION

发明人： Anthony R. Horton ,  David Filipiak ,  Albert A. Lepage, Jr.

IPC分类号： A61F2/02 ,  A61F2/00

CPC分类号： A61F2/0063 ,  A61F2/02 ,  A61F2002/0072 ,  A61F2210/0076 ,  A61F2230/0091 ,  A61F2250/0071

摘要： A medical device including a mesh prosthesis having a first layer having an opening a second layer secured to the first layer and forming a pocket therebetween. A deployment device is positioned in the pocket and arranged to resiliently exert a deployment force on the mesh prosthesis to urge the mesh prosthesis into a deployment shape. The deployment device has a first shape when deployed that has at least one dimension larger than that of the opening to frustrate removal of the deployment device therethrough. Upon application of a suitable pulling force the deployment device is reconfigurable into a second shape that permits the deployment device to be removed from the pocket through the opening upon application of the suitable pulling force. A method of using a medical device is also included.

公开(公告)号：US20170333173A1

公开(公告)日：2017-11-23

申请号：US15535682

申请日：2015-12-04

申请人： BIOS Co., Ltd

发明人： Takashi YOKOO ,  Eiji KOBAYASHI ,  Hiroshi NAGASHIMA ,  Hitomi MATSUNARI

IPC分类号： A61F2/02 ,  A61F2/04

CPC分类号： A61F2/02 ,  A01K67/0273 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2227/108 ,  A61F2/04 ,  A61F2/042 ,  A61F2002/048 ,  A61F2250/0091 ,  A61L27/36 ,  A61L27/3679 ,  A61L2430/22 ,  A61L2430/26 ,  A61M1/14 ,  C12N5/0684

摘要： An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.

公开(公告)号：US09814559B1

公开(公告)日：2017-11-14

申请号：US11988450

申请日：2000-08-01

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/02

CPC分类号： A61F2/02 ,  A61N1/3787

摘要： A medical implant apparatus includes or uses an energy transmission device for wireless transmission of energy of a first form from outside a patient's body. An implanted medical device is operable in response to energy of a second form different than the energy of the first form. An implanted energy transforming device transforms energy of the first form wirelessly transmitted by the energy transmission device into energy of the second form for use in the control and operation of the medical device.

公开(公告)号：US20170304006A1

公开(公告)日：2017-10-26

申请号：US15517034

申请日：2014-12-01

申请人： Brainlab AG

发明人： Bálint VARKUTI

IPC分类号： A61B34/10 ,  A61F2/02 ,  G06F19/00 ,  A61B34/20 ,  A61B90/00

CPC分类号： A61B34/10 ,  A61B34/20 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/108 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/3925 ,  A61B2090/3937 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/397 ,  A61B2090/3983 ,  A61F2/02 ,  A61F2240/002 ,  A61F2250/0097 ,  A61F2250/0098 ,  G16H50/50

摘要： A data processing method performed by a computer (2) for determining the structure of a medical implant (12; 18; 20; 22) which is to replace removed tissue in a patient's body, comprising the steps of:—acquiring a 3D dataset which represents remaining tissue (10; 17) which at least partly surrounded the removed tissue before the latter was removed;—determining the required contour of the implant (12; 18; 20; 22) from the 3D dataset;—simulating forces exerted by the remaining tissue (10; 17) on the contour of the implant (12; 18; 20;22); and—determining a structure dataset which represents the structure of the implant (12; 18; 20; 22) such that the implant (12; 18; 20; 22) has the required contour and can absorb the simulated forces.