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    DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF
    23.
    发明申请
    DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF 审中-公开
    药物递送系统及其制造方法

    公开(公告)号：US20140236286A1

    公开(公告)日：2014-08-21

    申请号：US14238271

    申请日：2012-08-17

    Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

    Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

    IPC: A61F2/82 ,  A61L31/16

    CPC classification number: A61F2/82 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  H01J27/026

    Abstract: A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed. Gas cluster ion beam and/or accelerated Neutral Beam derived from an accelerated gas cluster ion beam may be employed.

    Abstract translation: 适于用作药物递送系统的用于手术植入物的医疗装置具有一个或多个具有阻挡层的药物负载孔，以控制药物从孔中的释放或洗脱，或者控制流体向孔中的向内扩散。 阻挡层是非聚合物，并且由药物材料本身通过束加工形成。 孔可以是空间控制药物递送的图案。 灵活的选择允许药物组合，每孔可变药物剂量，每孔多种药物，药物释放顺序和形态的时间控制。 还公开了形成这种药物递送系统的方法。 可以采用来自加速气体团簇离子束的气体团簇离子束和/或加速中性束。

    Diamond-like carbon film with enhanced adhesion
    24.
    发明授权
    Diamond-like carbon film with enhanced adhesion 有权
    具有增强附着力的类金刚石碳膜

    公开(公告)号：US06660340B1

    公开(公告)日：2003-12-09

    申请号：US09717182

    申请日：2000-11-21

    Applicant: Sean R. Kirkpatrick

    Inventor： Sean R. Kirkpatrick

    IPC: C23C1448

    CPC classification number: B82Y30/00 ,  C23C14/024 ,  C23C14/0605 ,  C23C14/48 ,  C23C16/0272 ,  C23C16/26

    Abstract: A method and apparatus for enhancing the adhesion of a diamond-like carbon (DLC) film to a substrate and for producing a strongly adhered DLC film on a substrate. The adhesion is enhanced by ion beam pre-processing of the substrate prior to DLC film formation.

    Abstract translation: 一种用于增强类金刚石碳（DLC）膜与基底的粘附性并用于在基底上产生强粘附的DLC膜的方法和装置。 在DLC膜形成之前，通过离子束预处理衬底来增强粘附性。

    Apparatus and method for reduced particulate generation during workpiece handling
    25.
    发明授权
    Apparatus and method for reduced particulate generation during workpiece handling 失效
    减少工件处理过程中颗粒物产生的装置和方法

    公开(公告)号：US06595506B1

    公开(公告)日：2003-07-22

    申请号：US09715506

    申请日：2000-11-17

    Applicant: Barry M. Zide ,  Sean R. Kirkpatrick

    Inventor： Barry M. Zide ,  Sean R. Kirkpatrick

    IPC: B25B1106

    CPC classification number: H01L21/6875 ,  B25B11/005 ,  H01L21/68757 ,  Y10T279/23

    Abstract: This invention relates generally to the reduction of particulate material generation by workpiece handling components. Reduced levels of scratching, abrasion, wear and particulate generation are achieved by improved smoothing and flattening of the surface and, in a preferred embodiment, through the application of an ion beam assisted diamond-like-carbon film coating deposition.

    Abstract translation: 本发明一般涉及通过工件处理部件减少颗粒材料的产生。 通过改善表面的平滑化和平坦化，并且在优选的实施方案中，通过应用离子束辅助的类金刚石碳膜沉积来实现刮擦，磨损，磨损和颗粒产生的降低。

    Drug delivery system and method of manufacturing thereof
    27.
    发明授权
    Drug delivery system and method of manufacturing thereof 有权
    药物输送系统及其制造方法

    公开(公告)号：US08889169B2

    公开(公告)日：2014-11-18

    申请号：US12851161

    申请日：2010-08-05

    Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

    Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

    IPC: A61L27/54 ,  B05D3/06 ,  C23C14/02 ,  G21G5/00 ,  H01J37/317 ,  C23C14/22 ,  A61F2/82 ,  C23C14/50

    CPC classification number: C23C14/022 ,  A61F2/82 ,  A61F2250/0067 ,  C23C14/221 ,  C23C14/505 ,  H01J37/3171 ,  H01J2237/0812

    Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

    Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 这些改进可以应用于诸如血管支架的医疗装置的表面，并且可以用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。 可以使用掩模来将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

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