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公开(公告)号：US20130338216A1
公开(公告)日：2013-12-19
申请号：US13995058
申请日：2011-12-22
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , C07B59/002
摘要： The invention relates to (among other things) deuterated and/or fluorinated docetaxel and cabazitaxel and derivatives thereof, as well as compositions comprising each of the foregoing.
摘要翻译： 本发明涉及（尤其是）氘化和/或氟化多西紫杉醇和卡巴他赛及其衍生物，以及包含上述各项的组合物。
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22.发明申请公开(公告)号：US20130331443A1
公开(公告)日：2013-12-12
申请号：US13995287
申请日：2011-12-22
IPC分类号： C07D305/14
CPC分类号： A61K31/337 , A61K47/60 , C07D305/14 , C08G65/329 , C08G65/33337 , C08L2203/02
摘要： Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.
摘要翻译： 在其他方面中，本文提供的是紫杉烷类化合物和/或其氟化形式的多臂聚合物前药缀合物。 还提供了制备这种缀合物的方法以及给予缀合物的方法。 在给予患者时，实现了紫杉烷类化合物的释放。
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公开(公告)号：US20110036143A1
公开(公告)日：2011-02-17
申请号：US12911690
申请日：2010-10-25
IPC分类号： G01N29/02
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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公开(公告)号：US07805978B2
公开(公告)日：2010-10-05
申请号：US11876692
申请日：2007-10-22
IPC分类号： G01N29/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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公开(公告)号：US07726174B2
公开(公告)日：2010-06-01
申请号：US11876609
申请日：2007-10-22
IPC分类号： G01N29/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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26.发明授权Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages 失效具有与非膦酸酯核苷间键合混合的具有手性纯的磷酸酯核苷间键的合成低聚物
公开(公告)号：US5792615A
公开(公告)日：1998-08-11
申请号：US812861
申请日：1997-03-06
申请人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
发明人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
摘要： Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
摘要翻译： 提供了具有与RNA靶序列杂交的非膦酸酯核苷间键的手性纯膦酸核苷间键的寡聚物及其制备方法。
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27.发明授权
公开(公告)号：US5723599A
公开(公告)日：1998-03-03
申请号：US409902
申请日：1995-03-22
申请人： Robert E. Klem , Timothy A. Riley
发明人： Robert E. Klem , Timothy A. Riley
IPC分类号： C07H21/04 , C07H21/00 , C08F8/00 , C08F20/18 , C08F20/26 , C08F20/28 , C08F220/10 , C08F18/00
摘要： Polymeric reagents useful in the solid phase synthesis of oligomers are provided. These polymeric reagents are suitably loaded with nucleosidyl moieties and do not undergo non-specific chain elongation.
摘要翻译： 提供了可用于低聚物固相合成的聚合物试剂。 这些聚合物试剂适当地加载有核苷基部分并且不经历非特异性链延长。
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公开(公告)号：US08910370B2
公开(公告)日：2014-12-16
申请号：US12856447
申请日：2010-08-13
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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29.发明申请公开(公告)号：US20130023553A1
公开(公告)日：2013-01-24
申请号：US13521556
申请日：2011-01-12
IPC分类号： C07D489/02 , A61P25/36 , A61P25/00 , A61K31/485
CPC分类号： A61K31/075 , A61K31/485
摘要： Provided are methods for reducing the addiction potential and/or reducing one or more CNS-side effects related to the administration of an opioid analgesic drug by administering the opioid analgesic drug in the form of an oligomeric polyethylene glycol conjugate compound. The compounds provided demonstrate notably reduced potential for substance abuse, and possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist associated with certain alternative delivery formulations.
摘要翻译： 提供了通过以寡聚聚乙二醇缀合化合物的形式施用阿片样物质止痛药，降低成瘾潜能和/或降低与阿片类止痛药的给药有关的一种或多种CNS副作用的方法。 所提供的化合物显示出显着降低药物滥用的潜力，并且相对于单独的阿片样物质激动剂具有改变的药代动力学特征，但不具有物理篡改的风险，其允许与某些替代递送制剂相关的阿片样物质激动剂的恢复和滥用 。
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公开(公告)号：US08225639B2
公开(公告)日：2012-07-24
申请号：US12911690
申请日：2010-10-25
IPC分类号： G01N29/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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