公开(公告)号：US20190016789A1

公开(公告)日：2019-01-17

申请号：US16037340

申请日：2018-07-17

Applicant: Janssen Biotech, Inc.

Inventor： Chichi Huang ,  John Lee ,  Jill Mooney ,  Michael Naso

IPC: C07K16/18

Abstract: Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

公开(公告)号：US10179808B2

公开(公告)日：2019-01-15

申请号：US14163158

申请日：2014-01-24

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Wilson Edwards ,  Chichi Huang ,  Wai-Ping Leung ,  Ronald Swanson ,  Alan Wickenden

IPC: C07K14/435 ,  C07K14/765

Abstract: The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.

公开(公告)号：US20140255401A1

公开(公告)日：2014-09-11

申请号：US14163158

申请日：2014-01-24

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Wilson Edwards ,  Chichi Huang ,  Wai-Ping Leung ,  Ronald Swanson ,  Alan Wickenden

IPC: C07K14/435 ,  C07K14/765

CPC classification number: C07K14/43522 ,  C07K14/765 ,  C07K2319/30 ,  C07K2319/31

Abstract: The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.

Abstract translation: 本发明涉及Kv1.3拮抗剂和编码它们的多核苷酸，以及制备和使用上述物质的方法。

公开(公告)号：US11161897B2

公开(公告)日：2021-11-02

申请号：US16037340

申请日：2018-07-17

Applicant: Janssen Biotech, Inc.

Inventor： Chichi Huang ,  John Lee ,  Jill Mooney ,  Michael Naso

IPC: C07K16/28 ,  C07K16/46 ,  C07K14/735 ,  A61K39/395 ,  C07K16/18

Abstract: Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

公开(公告)号：US20190062383A1

公开(公告)日：2019-02-28

申请号：US16124295

申请日：2018-09-07

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Wilson Edwards ,  Chichi Huang ,  Wai-Ping Leung ,  Ronald Swanson ,  Alan Wickenden

IPC: C07K14/435 ,  C07K14/765

Abstract: The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.

公开(公告)号：US10155809B2

公开(公告)日：2018-12-18

申请号：US15707317

申请日：2017-09-18

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Judith Connor ,  Chichi Huang ,  Jarrat Jordan ,  Xiefan Lin-Schmidt ,  Jinquan Luo ,  Lu Lu ,  Christian Martinez ,  Galina Obmolova ,  Ronald Swanson

IPC: C07K16/24 ,  A61K39/00

Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω.

公开(公告)号：US20170327560A1

公开(公告)日：2017-11-16

申请号：US15586463

申请日：2017-05-04

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Judith Ann Connor ,  Jennifer Furman ,  Chichi Huang ,  Michael J. Hunter ,  Xiefan Lin-Schmidt ,  Serena Nelson ,  Shamina Rangwala ,  Shannon Mullican ,  Jose Antonio Chavez

IPC: C07K14/765 ,  C07K14/475 ,  A61K38/00

CPC classification number: C07K14/765 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/1875 ,  A61K38/19 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475 ,  C07K14/51 ,  C07K2319/31 ,  C12N5/12 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/62 ,  C12N15/63

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.