公开(公告)号：US20140322129A1

公开(公告)日：2014-10-30

申请号：US14207878

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K45/06 ,  A61K51/10 ,  A61K38/05 ,  A61K31/704 ,  A61K47/48 ,  G01N33/574

CPC classification number: C07K16/3015 ,  A61K31/5377 ,  A61K31/5517 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2827 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/567 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  A61K2300/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗B7-H4抗体和免疫缀合物及其使用方法。

公开(公告)号：US20140127197A1

公开(公告)日：2014-05-08

申请号：US13760751

申请日：2013-02-06

Applicant: GENENTECH, INC.

Inventor： Allen J. Ebens ,  Alane M. Gray ,  Wei-Ching Liang ,  Yan Wu ,  Shang-Fan Yu

IPC: C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/3061 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

Abstract: Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided.

Abstract translation: 提供抗CD22抗体及其免疫偶联物。 提供了使用抗CD22抗体及其免疫偶联物的方法。

公开(公告)号：US20130266581A1

公开(公告)日：2013-10-10

申请号：US13926801

申请日：2013-06-25

Applicant: Genentech, Inc.

Inventor： Germaine FUH ,  Hans-Peter Gerber ,  Wei-Ching Liang ,  Frederic Fellouse ,  Sachdev S. Sidhu ,  Christian Wiesmann

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

公开(公告)号：US20240279322A1

公开(公告)日：2024-08-22

申请号：US18420510

申请日：2024-01-23

Applicant: Genentech, Inc.

Inventor： Wei-Ching Liang ,  Joseph R. Arron ,  Daryle DePianto ,  Wendy Green Halpern ,  WeiYu Lin ,  Patrick J. Lupardus ,  Thirumalai Rajan Ramalingam ,  Dhaya Seshasayee ,  Tianhe Sun ,  Tulika Tyagi ,  Jia Wu ,  Yan Wu ,  Jian Ping Yin

IPC: C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61P11/00 ,  C07K16/464 ,  A61K39/39533 ,  A61K39/39566 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.

公开(公告)号：US11466087B2

公开(公告)日：2022-10-11

申请号：US16658706

申请日：2019-10-21

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Steven R. Leong ,  Wei-Ching Liang ,  Mary Mathieu ,  Andrew G. Polson ,  Bing Zheng ,  Xiaocheng Chen ,  Cecilia Pui Chi Chiu ,  Mark S. Dennis ,  Allen Ebens ,  Yan Wu

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.

公开(公告)号：US11084877B2

公开(公告)日：2021-08-10

申请号：US16250398

申请日：2019-01-17

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20200148774A1

公开(公告)日：2020-05-14

申请号：US16658706

申请日：2019-10-21

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Steven R. Leong ,  Wei-Ching Liang ,  Mary Mathieu ,  Andrew G. Polson ,  Bing Zheng ,  Xiaocheng Chen ,  Cecilia Pui Chi Chiu ,  Mark S. Dennis ,  Allen Ebens ,  Yan Wu

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.

公开(公告)号：US10421821B2

公开(公告)日：2019-09-24

申请号：US15336171

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/40

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US10239947B2

公开(公告)日：2019-03-26

申请号：US15657471

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10227412B2

公开(公告)日：2019-03-12

申请号：US15657476

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: G01N33/574 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.