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Patent Agency Ranking
公开(公告)号：US20150322136A1
公开(公告)日：2015-11-12
申请号：US14812695
申请日：2015-07-29
Applicant: Genentech, Inc.
Inventor： Pierre A. Barthelemy , Sachdev S. Sidhu
IPC: C07K16/00
CPC classification number: C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569
Abstract: The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.
Abstract translation: 本发明提供具有增加的折叠稳定性的变体重链可变结构域（VH）。 还提供了包含多个这些多肽的文库。 此外，提供了产生和使用这些多肽和文库的组合物和方法。
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公开(公告)号：US08975381B2
公开(公告)日：2015-03-10
申请号：US13929338
申请日：2013-06-27
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
CPC classification number: C07K16/22 , A61K2039/505 , A61K2039/55 , A61K2039/552 , C07K16/005 , C07K16/32 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。
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公开(公告)号：US20130266581A1
公开(公告)日：2013-10-10
申请号：US13926801
申请日：2013-06-25
Applicant: Genentech, Inc.
Inventor： Germaine FUH , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号：US09353177B2
公开(公告)日：2016-05-31
申请号：US14636782
申请日：2015-03-03
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC: C07K16/22 , A61K39/395 , C12P21/08
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号：US09018357B2
公开(公告)日：2015-04-28
申请号：US13926801
申请日：2013-06-25
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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