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    Copolymer Synthesis Process
    21.
    发明申请
    Copolymer Synthesis Process 有权
    共聚物合成工艺

    公开(公告)号：US20090312504A1

    公开(公告)日：2009-12-17

    申请号：US12477565

    申请日：2009-06-03

    申请人： Klaus K. Lorenz ,  Alexander Kraus ,  Barbara Wimmer ,  Petra Wagner ,  Christian Scholz ,  Manfred Bichler

    发明人： Klaus K. Lorenz ,  Alexander Kraus ,  Barbara Wimmer ,  Petra Wagner ,  Christian Scholz ,  Manfred Bichler

    IPC分类号： C08F2/04

    CPC分类号： C04B28/02 ,  C04B24/2647 ,  C04B24/2694 ,  C04B2103/308 ,  C08F216/1416 ,  C08F220/26 ,  Y10S526/915 ,  C04B2103/302

    摘要： Preparing a non-ionic copolymer having a hydrolysable monomer residue and a polyether macromonomer residue in a semicontinuous mode in a polymerization reactor associated with a metering device, including introducing polyether macromonomer and water into the reactor, wherein hydrolysable monomer which is added thereto forms a polymerization reaction mixture; introducing hydrolysable monomer into the metering device; adding hydrolysable monomer into the reactor from the metering device; passing a free radical polymerization initiator into the reactor before and/or during the addition of the hydrolysable monomer, the hydrolysable monomer and the polyether macromonomer reacting by free radical polymerization to form the non-ionic copolymer; and, subjecting the reaction mixture to polymerization while an addition rate of the hydrolysable monomer and/or at least a component of the polymerization initiator is varied stepwise or continuously. No monomer is introduced to incorporate ionic cement binding sites into the non-ionic copolymer.

    摘要翻译： 在与计量装置相关联的聚合反应器中制备具有可水解单体残基和聚醚大分子单体残基的非离子共聚物，其包括将聚醚大分子单体和水引入反应器，其中加入的可水解单体形成聚合 反应混合物; 将可水解单体引入计量装置; 从计量装置将可水解单体加入到反应器中; 在可水解单体加入之前和/或期间将自由基聚合引发剂通入自由基聚合引发剂，可水解单体和聚醚大分子单体通过自由基聚合反应形成非离子共聚物; 并且使反应混合物进行聚合，同时可水解单体和/或至少一种聚合引发剂组分的添加速率逐步或连续地改变。 没有引入单体以将离子水泥结合位点引入非离子共聚物。

    SlpA as a tool for recombinant protein and enzyme technology
    22.
    发明申请
    SlpA as a tool for recombinant protein and enzyme technology 有权
    SlpA作为重组蛋白和酶技术的工具

    公开(公告)号：US20090291892A1

    公开(公告)日：2009-11-26

    申请号：US12436396

    申请日：2009-05-06

    申请人： Christian Scholz ,  Elke Faatz ,  Urban Schmitt ,  Peter Schaarschmidt

    发明人： Christian Scholz ,  Elke Faatz ,  Urban Schmitt ,  Peter Schaarschmidt

    IPC分类号： A61K38/16 ,  G01N33/53 ,  C12P21/06 ,  C12N5/00 ,  C12N15/63 ,  C07K14/00 ,  C07H21/04

    CPC分类号： C12N15/62 ,  C12N9/90 ,  G01N33/536 ,  G01N33/54393 ,  Y02A50/57

    摘要： Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.

    摘要翻译： 公开了编码包含SlpA伴侣和靶多肽的融合蛋白的重组DNA分子，其中人FK506结合蛋白（FKBP）被排除为靶多肽，编码所述融合蛋白的相应表达载体以及用所述表达载体转化的宿主细胞 。 还公开了产生融合蛋白的方法，重组产生的包含SlpA伴侣和靶多肽的融合蛋白。 本发明的另一方面是使用重组产生的融合蛋白，以及含有重组产生的包含SlpA伴侣和靶多肽的融合蛋白的试剂盒。

    Copolymers Based On Unsaturated Monocarboxylic or Dicarboxylic Acid Derivatives and Oxyalkylene Glycol Alkenyl Ethers, Process for Preparing Them and Their Use
    23.
    发明申请
    Copolymers Based On Unsaturated Monocarboxylic or Dicarboxylic Acid Derivatives and Oxyalkylene Glycol Alkenyl Ethers, Process for Preparing Them and Their Use 审中-公开
    基于不饱和单羧酸或二羧酸衍生物和氧亚烷基二醇乙烯基醚的共聚物，其制备方法及其应用

    公开(公告)号：US20090163622A1

    公开(公告)日：2009-06-25

    申请号：US12084665

    申请日：2006-12-20

    申请人： Gerhard Albrecht ,  Klaus Lorenz ,  Christian Scholz ,  Petra Wagner

    发明人： Gerhard Albrecht ,  Klaus Lorenz ,  Christian Scholz ,  Petra Wagner

    IPC分类号： C08F220/00 ,  C08F222/04 ,  C08F216/12 ,  C08K3/00 ,  C08K3/30

    CPC分类号： C04B24/2605 ,  C04B24/2647 ,  C04B24/267 ,  C04B24/2694 ,  C04B2103/30 ,  C04B2103/408 ,  C08F216/1416 ,  C08F220/06 ,  C08F222/06

    摘要： Copolymers based on unsaturated mono- or dicarboxylic acid derivatives, oxyalkylene glycol alkenyl ethers and optionally vinylic polyalkylene glycol or ester compounds are described and also their use as additives for aqueous suspensions based on mineral or bituminous binders, in particular cement, gypsum, lime, anhydrite, or other calcium sulphate-based binders, and based on pulverulent dispersion binders. The copolymers according to the invention impart to the aqueous binder suspensions a very good dispersing and liquefying action with, at the same time, simultaneous excellent processing properties. Moreover, the oxyalkylene glycol alkenyl ethers according to the invention are industrially relatively simple and inexpensive to prepare and need comparatively low initiator concentrations in the copolymerization.

    摘要翻译： 描述了基于不饱和单羧酸或二羧酸衍生物，氧亚烷基二醇烯基醚和任选的乙烯基聚亚烷基二醇或酯化合物的共聚物，也用作基于矿物或沥青粘合剂，特别是水泥，石膏，石灰，无水石膏 ，或其它基于硫酸钙的粘合剂，并且基于粉末分散粘合剂。 根据本发明的共聚物赋予水性粘合剂悬浮液非常好的分散和液化作用，同时具有同时优异的加工性能。 此外，根据本发明的氧亚烷基二醇烯基醚在工业上相对简单且制备成本低，并且在共聚中需要相对较低的引发剂浓度。

    CHIMERIC FUSION PROTEIN
    24.
    发明申请
    CHIMERIC FUSION PROTEIN 有权
    CHIMERIC融合蛋白

    公开(公告)号：US20090042251A1

    公开(公告)日：2009-02-12

    申请号：US12166574

    申请日：2008-07-02

    申请人： Christian Scholz ,  Elke Faatz ,  Peter Schaarschmidt ,  Urban Schmitt

    发明人： Christian Scholz ,  Elke Faatz ,  Peter Schaarschmidt ,  Urban Schmitt

    IPC分类号： C12P21/04 ,  C12N15/11 ,  C12N9/90 ,  C12N15/00 ,  C12N1/20

    CPC分类号： C12N9/90 ,  C07K2319/35

    摘要： The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule comprising nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain). In particular, this invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule comprising nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for a human FKBP type peptidyl-prolyl-cis/trans isomerase (PPIase), methods of producing these chimeric fusion proteins and their uses as folding helpers in the production of other proteins and in the process of the production of vaccines or pharmaceuticals, and as folding helpers for performing immunoassays.

    摘要翻译： 本发明公开了与野生型伴侣相比，具有优异的伴侣和折叠活性的嵌合融合蛋白的克隆，表达和用途。 本发明涉及由重组DNA分子编码的嵌合融合蛋白，其包含编码非人伴侣蛋白多肽结合片段的核苷酸序列和编码FK506结合蛋白（FKBP）或FK506-结合蛋白 - 像域（FKBP样域）。 特别地，本发明涉及由重组DNA分子编码的嵌合融合蛋白，其包含编码非人伴侣蛋白多肽结合片段的核苷酸序列和编码人FKBP型肽基 - 脯氨酰 - 顺/反异构酶的核苷酸序列 （PPIase），生产这些嵌合融合蛋白的方法及其在生产其他蛋白质和疫苗或药物生产过程中作为折叠助剂的用途，以及用于进行免疫测定的折叠助剂。

    Semi-continuous method for producing copolymers
    27.
    发明授权
    Semi-continuous method for producing copolymers 有权
    半连续共聚物的制备方法

    公开(公告)号：US08536285B2

    公开(公告)日：2013-09-17

    申请号：US13133026

    申请日：2009-11-25

    申请人： Reinhard Dorfner ,  Klaus Lorenz ,  Petra Wagner ,  Christian Scholz

    发明人： Reinhard Dorfner ,  Klaus Lorenz ,  Petra Wagner ,  Christian Scholz

    IPC分类号： C08F216/14 ,  C08F2/10 ,  C08F224/00 ,  C04B16/04

    CPC分类号： C08F290/00 ,  C08F265/00 ,  C08F267/00 ,  C08F283/06 ,  C08F290/062 ,  C08F290/142 ,  C08L51/003 ,  C08L2666/02

    摘要： A process for the preparation of a copolymer in semicontinuous operation in a polymerization apparatus including a polymerization reactor connected to a metering device, acid monomer being initially taken in the metering device and polyether macromonomer and water in the polymerization reactor, acid monomer being metered from the metering device via an acid monomer metering line into the polymerization reactor, a portion of the copolymer-containing aqueous medium being passed continuously during the free radical polymerization from the polymerization reactor via a reaction mixture line which is connected via a mixing device to the acid monomer metering line, the discharged copolymer-containing aqueous medium being mixed with the acid monomer in the mixing device during the metering of the acid monomer and being recycled to the polymerization reactor after the mixing via the acid monomer metering line.

    摘要翻译： 一种在包括连接到计量装置的聚合反应器的聚合装置中的半连续操作中制备共聚物的方法，初始计量装置中的酸单体和聚合反应器中的聚醚大分子单体和水，酸单体从 计量装置通过酸性单体计量管线进入聚合反应器，一部分含共聚物的水性介质在自由基聚合期间通过经由混合装置连接到酸单体的反应混合物线从聚合反应器中连续通过 计量管线，在计量酸性单体期间将含有共聚物的含水介质与酸性单体混合在混合装置中，并通过酸性单体计量管道在混合后再循环到聚合反应器中。

    Copolymer synthesis process
    30.
    发明授权
    Copolymer synthesis process 有权
    共聚物合成工艺

    公开(公告)号：US07973110B2

    公开(公告)日：2011-07-05

    申请号：US12477565

    申请日：2009-06-03

    申请人： Klaus K. Lorenz ,  Alexander Kraus ,  Barbara Wimmer ,  Petra Wagner ,  Christian Scholz ,  Manfred Bichler

    发明人： Klaus K. Lorenz ,  Alexander Kraus ,  Barbara Wimmer ,  Petra Wagner ,  Christian Scholz ,  Manfred Bichler

    IPC分类号： C08F2/10 ,  C08F2/16 ,  C08F216/14

    CPC分类号： C04B28/02 ,  C04B24/2647 ,  C04B24/2694 ,  C04B2103/308 ,  C08F216/1416 ,  C08F220/26 ,  Y10S526/915 ,  C04B2103/302

    摘要： Preparing a non-ionic copolymer having a hydrolysable monomer residue and a polyether macromonomer residue in a semicontinuous mode in a polymerization reactor associated with a metering device, including introducing polyether macromonomer and water into the reactor, wherein hydrolysable monomer which is added thereto forms a polymerization reaction mixture; introducing hydrolysable monomer into the metering device; adding hydrolysable monomer into the reactor from the metering device; passing a free radical polymerization initiator into the reactor before and/or during the addition of the hydrolysable monomer, the hydrolysable monomer and the polyether macromonomer reacting by free radical polymerization to form the non-ionic copolymer; and, subjecting the reaction mixture to polymerization while an addition rate of the hydrolysable monomer and/or at least a component of the polymerization initiator is varied stepwise or continuously. No monomer is introduced to incorporate ionic cement binding sites into the non-ionic copolymer.

    摘要翻译： 在与计量装置相关联的聚合反应器中制备具有可水解单体残基和聚醚大分子单体残基的非离子共聚物，其包括将聚醚大分子单体和水引入反应器，其中加入的可水解单体形成聚合 反应混合物; 将可水解单体引入计量装置; 从计量装置将可水解单体加入到反应器中; 在可水解单体加入之前和/或期间将自由基聚合引发剂通入自由基聚合引发剂，可水解单体和聚醚大分子单体通过自由基聚合反应形成非离子共聚物; 并且使反应混合物进行聚合，同时可水解单体和/或至少一种聚合引发剂组分的添加速率逐步或连续地改变。 没有引入单体以将离子水泥结合位点引入非离子共聚物。