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公开(公告)号：US20130207639A1
公开(公告)日：2013-08-15
申请号：US13764612
申请日：2013-02-11
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Chieh-Feng Chang , Akram Sarwat Sadek , Axel Scherer , Raymond Jimenez
IPC: G01R19/00
CPC classification number: G01R19/00 , A61B5/0031 , A61B5/04001 , A61B2560/0214 , A61B2562/0209 , A61B2562/0233 , A61B2562/164 , A61B2562/166 , A61B2562/223
Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.
Abstract translation: 一种半导体衬底上的电压感测装置，包括一个或多个包括金属触点的输入端，包括激光发射器的输出端，将输入电连接到输出端的电路; 和电源模块。 还描述了制造该装置的方法。
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公开(公告)号：US11866768B2
公开(公告)日：2024-01-09
申请号：US16937464
申请日：2020-07-23
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , C12Q1/6825 , G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , G06F17/10 , G06F17/11 , G16B40/00
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10 , G06F17/11 , G16B40/00 , Y02A50/30 , C12Q1/6851 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US11660066B2
公开(公告)日：2023-05-30
申请号：US16547544
申请日：2019-08-21
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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公开(公告)号：US20210076954A1
公开(公告)日：2021-03-18
申请号：US17020740
申请日：2020-09-14
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Dominic Yurk , Yaser Abu-Mostafa , Alaina Ann Brinley Rajagopal
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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公开(公告)号：US10889863B2
公开(公告)日：2021-01-12
申请号：US16102583
申请日：2018-08-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer , Mark D. Goldberg
IPC: C12Q1/68 , C12Q1/70 , C12Q1/6883 , C12Q1/6851
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
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Patent Agency Ranking
公开(公告)号：US20190032112A1
公开(公告)日：2019-01-31
申请号：US16051736
申请日：2018-08-01
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
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公开(公告)号：US20170362636A1
公开(公告)日：2017-12-21
申请号：US15623974
申请日：2017-06-15
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
CPC classification number: C12Q1/686 , B01J2219/00659 , C07H21/04 , G01N2021/6417
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
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公开(公告)号：US09618477B2
公开(公告)日：2017-04-11
申请号：US13967108
申请日：2013-08-14
Applicant: California Institute of Technology
Inventor： Sameer Walavalkar , Axel Scherer , Thomas A. Tombrello , Aditya Rajagopal , Andrew P. Homyk , Erika Garcia
IPC: G01N27/447 , C12Q1/68 , G01N33/487 , B82Y30/00
CPC classification number: G01N27/447 , B82Y30/00 , C12Q1/6869 , G01N33/48721 , C12Q2563/116 , C12Q2565/631
Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.
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公开(公告)号：US09606060B2
公开(公告)日：2017-03-28
申请号：US13740112
申请日：2013-01-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Aditya Rajagopal , Axel Scherer
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/6408
Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.
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30.发明授权公开(公告)号：US09525312B2
公开(公告)日：2016-12-20
申请号：US14840819
申请日：2015-08-31
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Axel Scherer , Aditya Rajagopal , Seheon Kim , Andrew P. Homyk
IPC: H04B10/08 , H02J17/00 , G01J3/02 , H01L31/0352 , H03F3/08 , H03F3/45 , H04B10/80 , H02S40/38 , H01L31/0475 , H01L31/054 , A61B5/00
CPC classification number: H02J50/30 , A61B5/0017 , A61B5/6867 , A61B2560/0219 , G01J3/02 , G01J3/0218 , G01J3/0283 , G01N21/25 , H01L31/03529 , H01L31/0475 , H01L31/054 , H02J7/025 , H02J17/00 , H02J50/80 , H02S40/38 , H03F3/082 , H03F3/45183 , H03F2203/45702 , H04B10/807 , Y02E10/52
Abstract: The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.
Abstract translation: 本公开描述了一种用于利用光伏收集器对换能器和相关换能器进行光学供电的方法。 还提供了光纤功率传递方法和自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。
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