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公开(公告)号：US20240092043A1
公开(公告)日：2024-03-21
申请号：US18450451
申请日：2023-08-16
Applicant: Alcon Inc.
Inventor： Frank Chang , Troy Vernon Holland , Thomas M. Moy
CPC classification number: B29D11/00134 , C08F20/06 , C08F30/02 , C08J7/056 , G02B1/043
Abstract: The invention is related to a cost-effective method for making a coated contact lens having a hydrogel coating thereon. A method of the invention involves heating a contact lens precursor having carboxylic acid groups on and/or near its surface in an aqueous solution in the presence of a hydrophilic copolymer that comprises monomeric units of (a) at least one epoxy-containing vinylic monomer, (b) at least one amino-containing vinylic monomer having a primary or secondary amino group, (c) at least one polyethyleneglycol-containing vinylic monomer, and (d) at least one phosphorylcholine-containing vinylic monomer, at a temperature from about 100° C. to about 140° C. for at least 30 minutes, thereby forming a hydrogel coating on the contact lens precursor. Such a method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20230374225A1
公开(公告)日：2023-11-23
申请号：US18321416
申请日：2023-05-22
Applicant: Alcon Inc.
Inventor： Houliang Tang , Adam K. Sniady , Frank Chang , Troy Vernon Holland
IPC: C08G77/452
CPC classification number: C08G77/452
Abstract: Described herein is a method for producing HEVL-filtering contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The polymerizable composition comprises at least one N-vinyl amide monomer and at least one Cu(II)-meso-aryl-substituted porphyrin free of any ethylenically unsaturated group. The resultant HEVL-filtering contact lenses each comprise a polymer matrix to which the Cu(II)-meso-aryl-substituted porphyrin is grafted or covalently attached.
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公开(公告)号：US11802182B2
公开(公告)日：2023-10-31
申请号：US17742559
申请日：2022-05-12
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08L83/10 , G02B1/04 , C08G77/12 , B29D11/00 , G02C7/04
CPC classification number: C08G77/442 , B29D11/00134 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/043 , G02C7/04 , C08G2210/00 , C08L2201/10 , G02B2207/109
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20230004023A1
公开(公告)日：2023-01-05
申请号：US17838358
申请日：2022-06-13
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Chandana Kolluru , Steve Yun Zhang , Adam K. Sniady , Thomas M. Moy , Frank Chang , David Borja , Joseph Michael Lindacher , Ying Pi
Abstract: The invention provides a delamination-resistant embedded silicone hydrogel contact lens having an insert that is embedded in a silicone hydrogel bulk material. The insert is made of a crosslinked polymeric material having a refractive index higher than that of the silicone hydrogel bulk material by at least 0.07 and comprises a diffractive structure disposed on one of the front and back curve surfaces of the insert for providing a diffractive power that contributes to the overall optical power of the contact lens.
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公开(公告)号：US11365288B2
公开(公告)日：2022-06-21
申请号：US17038293
申请日：2020-09-30
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08L83/10 , G02B1/04 , C08G77/12 , B29D11/00 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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Patent Agency Ranking
公开(公告)号：US20200158913A1
公开(公告)日：2020-05-21
申请号：US16683886
申请日：2019-11-14
Applicant: Alcon Inc.
Inventor： Frank Chang , Houliang Tang , Troy Vernon Holland , Adam K. Sniady
IPC: G02B1/04 , G02C7/04 , C08F218/08 , C08F216/06 , C08F230/02 , C08F216/38 , G02B1/10
Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.
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公开(公告)号：US12285922B2
公开(公告)日：2025-04-29
申请号：US17688022
申请日：2022-03-07
Applicant: Alcon Inc.
Inventor： Houliang Tang , Frank Chang
Abstract: Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half.
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公开(公告)号：US20240254269A1
公开(公告)日：2024-08-01
申请号：US18435562
申请日：2024-02-07
Applicant: Alcon Inc.
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , C08G77/12 , C08G77/16 , C08G77/20 , C08G77/392 , G02B1/04
CPC classification number: C08F290/068 , C08G77/16 , C08G77/20 , C08G77/392 , G02B1/043 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20240052109A1
公开(公告)日：2024-02-15
申请号：US18359035
申请日：2023-07-26
Applicant: Alcon Inc.
Inventor： Frank Chang , Adam K. Sniady
CPC classification number: C08G77/26 , G02B1/043 , C08G2210/00
Abstract: The invention provides a polysiloxane vinylic monomer which comprises (1) a polysiloxane polymer chain comprising at least 5 dimethylsiloxane units in a consecutive sequence, (2) one sole terminal (meth)acryloyl or styrenyl group, and (3) a quaternary ammonium moiety. Due to presence of the quaternary ammonium moiety, a polysiloxane vinylic monomer of the invention is relatively compatible with hydrophilic vinylic monomers used in a silicone hydrogel lens formulation for making silicone hydrogel contact lenses. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units of a polysiloxane vinylic monomer of the invention.
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公开(公告)号：US11061169B2
公开(公告)日：2021-07-13
申请号：US16683886
申请日：2019-11-14
Applicant: Alcon Inc.
Inventor： Frank Chang , Houliang Tang , Troy Vernon Holland , Adam K. Sniady
IPC: G02B1/04 , C08F216/06 , C08F216/38 , C08F218/08 , C08F230/02 , G02B1/10 , G02C7/04
Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.
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