公开(公告)号：US20230043679A1

公开(公告)日：2023-02-09

申请号：US17960906

申请日：2022-10-06

Applicant: AMGEN INC.

Inventor： Sheldon Moberg ,  Matthew Wayne Janke ,  Wael Mismar ,  Alexis Dechelette

IPC: A61M5/162 ,  A61M5/142 ,  A61M5/20

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

公开(公告)号：US11484648B2

公开(公告)日：2022-11-01

申请号：US16625208

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Sheldon Moberg ,  Matthew Wayne Janke ,  Wael Mismar ,  Alexis Dechelette

IPC: A61M5/162 ,  A61M5/142 ,  A61M5/20

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

公开(公告)号：US20220288305A1

公开(公告)日：2022-09-15

申请号：US17626667

申请日：2020-07-16

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Scott R. Gibson ,  Sheldon Moberg ,  Paul Daniel Faucher

IPC: A61M5/145 ,  A61M5/142

Abstract: A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.

公开(公告)号：US20220152308A1

公开(公告)日：2022-05-19

申请号：US17590175

申请日：2022-02-01

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US11298463B2

公开(公告)日：2022-04-12

申请号：US16839267

申请日：2020-04-03

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/31 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US11129941B2

公开(公告)日：2021-09-28

申请号：US15047815

申请日：2016-02-19

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Son C. Tran ,  Sheldon Moberg ,  Mark D. Holt

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20210069416A1

公开(公告)日：2021-03-11

申请号：US16951987

申请日：2020-11-18

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Sheldon Moberg

IPC: A61M5/20 ,  A61M5/24 ,  A61M5/32

Abstract: A device, method, and system for drug delivery includes a casing for housing a drug storage container, the drug storage container including a dose delivery member, at least a portion of the dose delivery member extending through an opening in the casing; a guard movable relative to the casing between extended and retracted positions, the portion of the dose delivery member being surrounded by the guard in the extended position and the portion of the dose delivery member being at least partially exposed when the guard is in the retracted position; an interference arrangement for providing selected threshold of resistance to movement of the guard from the extended position to the retracted position during insertion of the dose delivery member into body tissue at an injection site, the detent arrangement having a first member associated with a surface within the casing, and a second member extending from the guard, the first and second members engaging one another to retain the guard in the extended position, one of the first and second members moving if the selected threshold of resistance is exceeded to allow the members to slide past one another to allow the guard to move into the retracted position when the device is pressed toward the injection site during insertion of the dose delivery member.

公开(公告)号：US20140288511A1

公开(公告)日：2014-09-25

申请号：US14350687

申请日：2012-10-11

Applicant: Francisca TAN-MALECKI ,  Ron FORSTER ,  Scott NUNN ,  Mark D. HOLT ,  Son TRAN ,  Sheldon MOBERG ,  AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ron Forster ,  Scott Nunn ,  Mark Dominis Holt ,  Son Tran ,  Sheldon Moberg

IPC: A61M5/162 ,  A61M5/172

CPC classification number: A61M5/31 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/148 ,  A61M5/158 ,  A61M5/162 ,  A61M5/1626 ,  A61M5/172 ,  A61M5/2455 ,  A61M5/2466 ,  A61M2005/247 ,  A61M2005/2474 ,  A61M2005/3114 ,  A61M2207/00 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/08 ,  B65B55/10

Abstract: An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.

Abstract translation: 注射器（100）可以包括容器（102），其具有带有内表面（112）的壁（110）和具有内表面（142）的密封组件（140），壁的内表面（110） 110）和所述密封组件（140）限定填充有药物的封闭的无菌容器（150）。 注射器（100）还可以包括流体递送系统，该流体输送系统包括清洁的，未套好的刚性容器针（180），其具有在存储状态下仅部分地设置穿过密封组件（140）的点（182），并且穿过内部 密封组件（140）的表面（142）在输送状态下进入无菌容器（150）。 此外，注射可以包括致动器（106），该致动器适于将容器针从储存状态移动到输送状态。

公开(公告)号：US20210330880A1

公开(公告)日：2021-10-28

申请号：US16625208

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Sheldon Moberg ,  Matthew Wayne Janke ,  Wael Mismar ,  Alexis Dechelette

IPC: A61M5/162 ,  A61M5/142 ,  A61M5/20

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

公开(公告)号：US20200230323A1

公开(公告)日：2020-07-23

申请号：US16839267

申请日：2020-04-03

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  A61M5/162 ,  A61M5/158 ,  A61M5/148 ,  A61M5/145 ,  A61M5/172 ,  A61M5/24 ,  B65B55/10 ,  B65B55/08 ,  B65B7/28 ,  B65B3/00

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.