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    Fluidic card assembly
    21.
    发明授权
    Fluidic card assembly 有权

    公开(公告)号：US11623214B2

    公开(公告)日：2023-04-11

    申请号：US16772593

    申请日：2018-12-07

    Applicant: Randox Laboratories Ltd

    Inventor： Stuart Jackson

    IPC: B01L3/00

    Abstract: A fluidic card assembly (1) comprises an inlet (20) for introducing a fluid to the fluidic card assembly (1), a turbulent flow portion (30) downstream of the inlet (20), the turbulent flow portion (30) comprising a widening fluid channel (31) whereby a fluid introduced via the inlet (20) channel undergoes turbulence, and a laminar flow portion (40) downstream of the turbulent flow portion (30). The laminar flow portion (40) is configured to allow fluid passing from the turbulent flow portion (30) into the laminar flow portion (40) to establish a laminar flow pattern, and is configured to house a biochip (44) such that a fluid in the laminar flow portion (40) may be in contact with the biochip (44).

    PIPETTE TIP CARRIER ASSEMBLY
    23.
    发明申请
    PIPETTE TIP CARRIER ASSEMBLY 有权

    公开(公告)号：US20220193685A1

    公开(公告)日：2022-06-23

    申请号：US17602897

    申请日：2020-04-08

    Applicant: RANDOX LABORATORIES LTD

    Inventor： Proinnsias McGleenan ,  P Evans ,  Stuart Jackson ,  Martin Reid ,  Peter Fitzgerald

    IPC: B01L9/00

    Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.

    Sample preparation method for analysis of platelet proteins
    24.
    发明授权
    Sample preparation method for analysis of platelet proteins 有权

    公开(公告)号：US10209167B2

    公开(公告)日：2019-02-19

    申请号：US15036811

    申请日：2014-11-13

    Applicant: Randox Laboratories Ltd.

    Inventor： Michael Veitinger ,  Maria Zellner

    IPC: G01N1/40 ,  C12Q1/48 ,  G01N33/68 ,  G01N33/86

    Abstract: The present invention provides a novel method of in vitro sample preparation for the analysis of proteins. In a first aspect, the present invention is a method comprising the separation and individual treatment of blood platelets and platelet-poor plasma obtained from a platelet-rich plasma sample. This allows for optimal treatment of both fractions and overcomes many of the problems associated with current methods. In a second aspect of the present invention the platelet sample preparation method can be implemented before a biochip based immunoassay for the detection of platelet proteins in combination with plasma proteins.

    MICROFLUIDIC CHIP
    29.
    发明申请
    MICROFLUIDIC CHIP 审中-公开

    公开(公告)号：US20170225160A1

    公开(公告)日：2017-08-10

    申请号：US15519096

    申请日：2015-10-15

    Applicant: Randox Laboratories Ltd.

    Inventor： Stuart Jackson ,  Martin Crockard ,  Steve Haswell

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/5027 ,  B01L3/5023 ,  B01L3/502738 ,  B01L2300/0887 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084

    Abstract: According to the invention there is a microfluidic chip 1 that includes at least two layers 10 forming a stack of layers, each layer of which has at least one flow channel 14; a bore 16 extending through the layers and communicating with a plurality of flow channels; and a valve 20, which has a shaft 22 with a recess 222 in a side of the shaft for fluid to flow through. The shaft is rotatably mounted in the bore, and has a first position in which the recess is aligned with each of at least two flow channels of the plurality of flow channels thereby providing a flow path between said at least two flow channels, and a second position in which the recess is unaligned with at least one of said at least two flow channels the flow path between said at least two flow channels thereby being closed. This allows a fluid flow path between two flow channels to be open and closed by rotation of the shaft so that fluid in the microfluidic chip can be redirected to allow the chip to have greater capability and by using a minimal amount of space on the chip to do so.

    METHOD FOR AIDING DIAGNOSIS OF ALZHEIMER'S DISEASE
    30.
    发明申请
    METHOD FOR AIDING DIAGNOSIS OF ALZHEIMER'S DISEASE 有权
    帮助阿尔茨海默病诊断的方法

    公开(公告)号：US20150247870A1

    公开(公告)日：2015-09-03

    申请号：US14431557

    申请日：2013-10-03

    Applicant: RANDOX LABORATORIES LTD

    Inventor： Ellen Umlauf ,  Maria Zellner

    IPC: G01N33/68 ,  G06F19/00 ,  G06F19/18

    CPC classification number: G01N33/6896 ,  G01N2333/4712 ,  G01N2333/775 ,  G01N2333/90 ,  G01N2333/90638 ,  G01N2333/91085 ,  G01N2800/2821 ,  G06F19/18 ,  G16H50/20

    Abstract: The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprising: (i) determining the number of alleles of ApoE4 in the patient's genome; (ii) determining the combined expression level of at least three platelet proteins in a platelet sample from the patient; and (iii) comparing the resulting value of step (ii) to a control value, wherein the at least three platelet proteins include at least one isoform of alpha-tropomyosin containing exon 1a and at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 or mutant GSTO-1, wherein a result higher than the control value is indicative of Alzheimer's disease.The invention also provides a solid support comprising one or more ligands of at least one isoform of alpha-tropomyosin containing exon 1a, and one or more ligands of at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 protein and/or mutant GSTO-1 protein immobilised thereon.

    Abstract translation: 本发明提供一种用于辅助患者中阿尔茨海默病诊断的离体方法，包括：（i）确定患者基因组中ApoE4的等位基因数; （ii）确定来自患者的血小板样品中至少三种血小板蛋白的组合表达水平; 和（iii）将步骤（ii）的所得值与对照值进行比较，其中所述至少三种血小板蛋白包括至少一种含有外显子1a的α-原肌球蛋白的同种型和至少两种选自单胺氧化酶-B的血小板蛋白， 凝血因子XIIIa，野生型GSTO-1或突变型GSTO-1，其中高于对照值的结果指示阿尔茨海默病。 本发明还提供了一种固体支持物，其包含一种或多种至少一种含有α-原肌球蛋白的外显子1a同种型的配体，以及一种或多种选自单胺氧化酶-B，凝血因子XIIIa，野生型的至少两种血小板蛋白的配体 固定在其上的GSTO-1蛋白和/或突变型GSTO-1蛋白。

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