公开(公告)号：US20250027052A1

公开(公告)日：2025-01-23

申请号：US18778486

申请日：2024-07-19

Applicant: AMGEN INC.

Inventor： Eugenia ZAH ,  Natalia GOMEZ ,  Kristine DARIS ,  Xing MA

IPC: C12N5/071 ,  C12N9/00 ,  C12N9/06 ,  C12N15/85

Abstract: Dual vector systems, and mammalian host cells comprising them, for the expression of multi chain molecules are provided where each vector employs a different promoter driving the expression of a selectable marker. The mammalian host cells can be used for producing a recombinant protein of interest in a mammalian cell culture.

公开(公告)号：US20250018122A1

公开(公告)日：2025-01-16

申请号：US18710112

申请日：2022-11-28

Applicant: AMGEN INC.

Inventor： Ryan Oba ,  Mher Asadourian ,  Sandra Sanchez ,  Chelsea Balli-Cruz ,  Joshua Tamsky

IPC: A61M5/31 ,  G01M99/00

Abstract: A testing system for a drug delivery device includes a frame member having first and second ends, a driving member positioned near the frame member, a surrogate syringe barrel operably coupled with the frame member, a flange extender adapted to couple with a portion of the surrogate syringe barrel, and a plunger rod adapted to couple with the flange extender and be at least partially disposed within the surrogate syringe barrel while being movable therein. The driving member is movable in an axial direction between the first end and the second end of the frame member. The plunger rod includes first and second ends and a longitudinal length therebetween, the first end being positioned near a portion of the driving member. The driving member measures a maximum urging force exerted on the plunger rod when moving in the axial direction towards the second end of the frame member.

公开(公告)号：US20250017825A1

公开(公告)日：2025-01-16

申请号：US18577029

申请日：2022-06-23

Applicant: AMGEN INC.

Inventor： Todd Neslund ,  Stephen Karl Shutt ,  Eunah Choi ,  Alberto David Herrera ,  Jordan Ray Fine ,  Thomas Clark Pearson

IPC: A61J7/02 ,  G01N15/14

Abstract: A system for dispensing, inspecting, and/or processing drug includes a tray adapted to be operably coupled with a workstation, a handle member operably coupled with the tray, and a funnel region operably coupled with the tray. The tray has a body defining a recessed region and a sidewall positioned adjacent to the recessed region. The handle member is positioned at or near a first corner of the tray. The funnel region is positioned at or near a second corner of the tray. The first corner is opposite the second corner.

公开(公告)号：US12195779B2

公开(公告)日：2025-01-14

申请号：US17746008

申请日：2022-05-17

Applicant: Amgen Inc.

Inventor： Chetan Goudar ,  Sean Cole ,  Nicole Sabo ,  Henry Lin ,  Jonathan Lull ,  Tharmala Tharmalingam

IPC: C12P21/00 ,  C07K16/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12N5/00

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.

公开(公告)号：US12194039B2

公开(公告)日：2025-01-14

申请号：US17454592

申请日：2021-11-11

Applicant: Cytokinetics, Inc. ,  Amgen Inc.

Inventor： Narimon Honarpour ,  Fady Malik

IPC: A61K31/497 ,  A61N1/39

Abstract: Provided herein are methods of treating heart failure in patients exhibiting one or more additional features, comprising administering to the patient a therapeutically effective amount of omecamtiv mecarbil, or a hydrate, salt, or salt of a hydrate thereof.

公开(公告)号：US12186536B2

公开(公告)日：2025-01-07

申请号：US17323830

申请日：2021-05-18

Applicant: AMGEN INC.

Inventor： Hans Stenberg Knudsen ,  Christian Plambech ,  Rasmus Øhlenschlæger ,  Jørgen Jørgensen

IPC: A61M5/20 ,  A61M5/145 ,  A61M5/32 ,  A61M5/142 ,  A61M5/315

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

公开(公告)号：US12178991B2

公开(公告)日：2024-12-31

申请号：US17359825

申请日：2021-06-28

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Jerome Olivas ,  Joshua Merilos ,  Matthew Wayne Janke ,  Justin Harris ,  Marc Orloff ,  Edward Stapleford Nielsen ,  Chitra Nadig ,  Yasaman Damestani ,  Guojie Song ,  Bryton De Guia

IPC: A61M5/142 ,  A61M5/20

Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.

公开(公告)号：US20240426793A1

公开(公告)日：2024-12-26

申请号：US18744883

申请日：2024-06-17

Applicant: AMGEN INC.

Inventor： Nicholas Anthony VECCHIARELLO ,  Venkatesh NATARAJAN ,  Andrew John MALONEY ,  Benjamin SMITH ,  Joseph Edward BASCONI

IPC: G01N30/14 ,  G01N30/02 ,  G01N30/80 ,  G01N30/88

Abstract: Disclosed herein are methods for chromatography, including cleaning methods for chromatography medium that make use of a linear salt gradient. The disclosed methods may be used for frontal chromatography operations and for cleaning frontal chromatography media for reuse in biologics manufacturing.

公开(公告)号：US20240425556A1

公开(公告)日：2024-12-26

申请号：US18685037

申请日：2022-08-19

Applicant: University of Cincinnati ,  Amgen Inc.

Inventor： Sakthivel Sadayappan, Sr. ,  Rohit Singh ,  Brandon Lee Ason

IPC: C07K14/47 ,  A61K9/00 ,  A61K38/00 ,  A61P9/04

Abstract: Myopeptides are provided, which include a myosin S2 fragment having at least 90% sequence identity to an amino acid sequence consisting of VKEMTERLEDEEEMNAELTAKK (SEQ ID NO: 1); and, optionally, a cardiac-homing peptide tag. Also provided are pharmaceutical compositions and methods of use of the myopeptides and pharmaceutical compositions in the treatment of heart failure.

公开(公告)号：US20240424223A1

公开(公告)日：2024-12-26

申请号：US18696203

申请日：2022-10-05

Applicant: AMGEN INC.

Inventor： Emil Gram Spork ,  Matias Melander ,  Alexandre Gegelashvili ,  Yangkun Song ,  Thomas Peter Sonderby

IPC: A61M5/32

Abstract: A drug delivery device includes a housing having proximal and distal ends and a longitudinal axis extending therebetween, an injection assembly at least partially disposed within the housing at or near the proximal end, a shield slidably coupled with the housing, a drive assembly operably coupled with the injection assembly and the shield, and a cap. The injection assembly includes a needle or a cannula. The shield is positionable in an extended position in which at least a proximal end thereof extends a distance beyond the proximal end of the housing. The drive assembly is engageable to deliver a medicament via the injection assembly. The cap is removably coupled with at least one of the shield or the housing and is adapted to limit movement of the shield when coupled with the shield and/or the housing such that the drive assembly is restricted from delivering the medicament via the injection assembly.