公开(公告)号：US11427848B2

公开(公告)日：2022-08-30

申请号：US17537766

申请日：2021-11-30

Applicant: Amgen Inc.

Inventor： Chetan Goudar ,  Sean Cole ,  Nicole Sabo ,  Henry Lin ,  Jonathan Lull ,  Tharmala Tharmalingam

IPC: C12P21/00 ,  C12M3/00 ,  C12M1/00 ,  C12N5/00 ,  C12M1/36 ,  C07K16/00 ,  C12M1/26

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.

公开(公告)号：US10829551B2

公开(公告)日：2020-11-10

申请号：US15150627

申请日：2016-05-10

Applicant: AMGEN INC.

Inventor： Jian Wu ,  Nicole Sabo ,  Michael De La Cruz ,  Gregory Flynn

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/00 ,  C12P21/00 ,  C12N5/00 ,  A61K39/00

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

公开(公告)号：US12195779B2

公开(公告)日：2025-01-14

申请号：US17746008

申请日：2022-05-17

Applicant: Amgen Inc.

Inventor： Chetan Goudar ,  Sean Cole ,  Nicole Sabo ,  Henry Lin ,  Jonathan Lull ,  Tharmala Tharmalingam

IPC: C12P21/00 ,  C07K16/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12N5/00

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.

公开(公告)号：US20160304603A1

公开(公告)日：2016-10-20

申请号：US15150627

申请日：2016-05-10

Applicant: AMGEN INC.

Inventor： Jian WU ,  Nicole Sabo ,  Michael DE LA Cruz ,  Gregory Flynn

IPC: C07K16/24 ,  C12P21/00 ,  C12N5/00

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.