公开(公告)号：US20230348566A1

公开(公告)日：2023-11-02

申请号：US18025637

申请日：2021-09-10

Applicant: Academia Sinica

Inventor： Chi-Ming LIANG ,  Jeng-Jer SHIEH ,  Chung-Hsuan CHEN ,  Shu-Mei LIANG

IPC: C07K14/765 ,  A61P35/00

CPC classification number: C07K14/765 ,  A61P35/00

Abstract: Re-folded human serum albumin (rfHSA) and use thereof for anti-tumor are disclosed. The rfHSA comprises the primary amino acid sequence of naive human serum albumin, in which the rfHSA in a solution is oval shape, not fibrillar, and the naive HSA is globular. The rfHSA is used for treating cancer or a tumor in a subject in need thereof The rfHSA may also be used as a reagent for detecting the presence of a cancer cell associated with integrin β1 or serine/threonine protein kinase Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) in a tumor sample or as a reagent for inhibiting phosphorylation of Akt and ERK 1/2 in a cancer cell sample. A cell lysate of a cancer cell treated with rfHSA, a vaccine composition comprising the cancer cell lysate, and use thereof are also disclosed. Also disclosed is a method tor preparing rfHSA.

公开(公告)号：US20230279080A1

公开(公告)日：2023-09-07

申请号：US18146873

申请日：2022-12-27

Applicant: ACADEMIA SINICA

Inventor： Kuo-I LIN ,  Chi-Huey WONG ,  Szu-Wen WANG ,  Yi-Hsuan CHANG

IPC: C07K16/10 ,  G01N33/569 ,  A61K45/06

CPC classification number: C07K16/10 ,  A61K45/06 ,  G01N33/56983 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2469/10

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that is specific for a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20230220065A1

公开(公告)日：2023-07-13

申请号：US18010647

申请日：2021-06-15

Applicant: ACADEMIA SINICA

Inventor： Andrew H.-J. WANG ,  Wen-Chih KUO ,  Cheng-Chung LEE ,  An-Suei YANG

IPC: C07K16/24 ,  A61P35/00 ,  A61K47/26 ,  C12N15/63

CPC classification number: C07K16/245 ,  A61P35/00 ,  A61K47/26 ,  C12N15/63 ,  A61K2039/505

Abstract: Disclosed herein are anti-IL-1β antibodies capable of binding to human IL-1β and blocking its biological activities. Also provided herein are pharmaceutical compositions comprising the anti-IL-1β antibodies and therapeutic and diagnostic uses of such antibodies.

公开(公告)号：US20230212554A1

公开(公告)日：2023-07-06

申请号：US18008753

申请日：2021-06-07

Applicant: An-Suei YU ,  Academia Sinica

Inventor： An-Suei YANG ,  Chung-Ming YU ,  Ing-Chien CHEN ,  Chao-Ping TUNG ,  Hung-Pin PENG

IPC: C12N15/10 ,  G01N33/569 ,  C07K16/10

CPC classification number: C12N15/1037 ,  G01N33/56983 ,  C07K16/1018 ,  G01N2333/11 ,  G01N2470/04 ,  C07K2317/622 ,  C07K2317/92

Abstract: Disclosed herein are methods for selecting an antibody fragment specific to an influenza virus. According to certain embodiments of the present disclosure, the influenza virus may be influenza virus type A (IAV) or influenza virus type B (IBV). Also disclosed herein are the selected antibodies, recombinant antibody produced from the selected antibodies, and the uses thereof in the diagnosis of influenza virus infection.

公开(公告)号：US20230184751A1

公开(公告)日：2023-06-15

申请号：US17925119

申请日：2021-05-14

Applicant: Ming-Che SHIH ,  ACADEMIA SINICA

Inventor： Wen-Bin YANG

IPC: G01N33/53 ,  G01N30/72 ,  G01N33/58

CPC classification number: G01N33/5308 ,  G01N30/7233 ,  G01N33/58 ,  G01N2030/027

Abstract: The present invention relates to a system and method for carbohydrate analysis in a flow chemistry manner. The present invention at least features continuous reactions of glycan hydrolysis in combination with saccharide labeling which is helpful to improve the existing approaches in glycan structural analysis.

公开(公告)号：US20230074185A1

公开(公告)日：2023-03-09

申请号：US17933832

申请日：2022-09-20

Applicant: Academia Sinica

Inventor： Chi-Huey WONG ,  Chung-Yi WU

IPC: F27D1/12 ,  F27B3/14 ,  F27B3/24 ,  F27D11/08

Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.

公开(公告)号：US20230042448A1

公开(公告)日：2023-02-09

申请号：US17806932

申请日：2022-06-14

Applicant: ACADEMIA SINICA

Inventor： Patrick CH HSIEH ,  Hung-Chih CHEN

IPC: C12Q1/689

Abstract: The disclosure provides a method for or the early diagnosis, prognosis and differentiation of myocardial infarction (MI). The method comprises performing genetic analysis on gut microbiota. The disclosure also provides a biomarker and kit for the early diagnosis, prognosis, recurrence and differentiation of MI.

公开(公告)号：US11549946B2

公开(公告)日：2023-01-10

申请号：US16516475

申请日：2019-07-19

Applicant: National Tsing Hua University ,  ACADEMIA SINICA

Inventor： Gwo Bin Lee ,  Shang-Cheng Hung ,  Wei-Chun Tsai

IPC: G01N33/574 ,  B01L9/00 ,  G01N33/543

Abstract: The present disclosure provides a method for detecting cholangiocarcinoma cells. The capture rate of the cholangiocarcinoma cells of the present disclosure is higher than 70%, and a plurality of octasaccharides with high affinity and specificity can be modified on the surface of magnetic beads to capture and analyze cholangiocarcinoma cells under test, wherein the cholangiocarcinoma cells can be circulating tumor cells in cholangiocarcinoma.

公开(公告)号：US20230002778A1

公开(公告)日：2023-01-05

申请号：US17760803

申请日：2020-09-17

Applicant: ACADEMIA SINICA ,  NATIONAL CENTRAL UNIVERSITY

Inventor： Su-May YU ,  Yi-Shih CHEN ,  Chung-An LU ,  Tuan-Hua David HO

IPC: C12N15/82

Abstract: Provided herein is a method for improving growth, stress tolerance and productivity of a plant. Also provided herein is a method for increasing seed quality of a plant. Specifically, the disclosure provides a method for improving growth, stress tolerance and productivity of a plant, comprising: providing a transgenic plant, which includes a reduced expression on an MYBS2 gene as relative to its wild-type counterpart; and a method for increasing seed quality of a plant, comprising: providing a seed from a transgenic plant, which overexpresses a full-length MYBS2 gene or a mutant MYBS2 gene as relative to its wild-type counterpart.

公开(公告)号：US20220390628A1

公开(公告)日：2022-12-08

申请号：US17805869

申请日：2022-06-08

Applicant: Academia Sinica ,  National Central University

Inventor： Mythra Varun Nemallapudi ,  Chih-Hsun Lin ,  Shih-Chang Lee ,  Augustine Ei-fong Chen

IPC: G01T1/20

Abstract: The invention is related to particle induced radiography system, comprising a particle radiation source device, implant module, external detector device, central module and other controls, in which the implant module comprises active and/or passive components in tandem with the readout electronics and communication chosen to measure the beam properties and to generate and detect secondary gamma photons from the nuclear interactions, the external detector device provides a position sensitive gamma detector with a high detection efficiency, good spatial resolution and a relatively large field of view necessary for particle treatments useful in monitoring both the implanted device and the patient anatomical areas under treatment, and the external detector device can also be used to perform 3D spectral imaging on any material samples using proton beam as a probe.