知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

295 records (took 0.032 seconds)

    Bioactive polymers
    12.
    发明授权
    Bioactive polymers 有权
    生物活性聚合物

    公开(公告)号：US09567294B2

    公开(公告)日：2017-02-14

    申请号：US14763356

    申请日：2014-01-22

    Applicant: Sealife Pharma GmbH

    Inventor： Alexander Pretsch ,  Michael Nagl ,  Christoph Wiesner ,  Heinz Burgmann

    IPC: C07C279/00 ,  C08G73/02 ,  A01N47/40 ,  C07C277/08 ,  C07C279/08

    CPC classification number: C07C279/00 ,  A01N47/40 ,  C07C277/08 ,  C07C279/08 ,  C08G73/02

    Abstract: Polycondensation products of aminoguanidine and/or 1,3-diaminoguanidine with one or more diamines are provided including polyguanidine derivatives of the following formula (I) or a salt thereof: wherein X is selected from —NH2, aminoguanidino and 1,3-diaminoguanidino; Y is selected from —H and —R1—NH2; or X and Y together represent a chemical bond to give a cyclic structure; R1 is selected from divalent organic radicals having 2 to 20 carbon atoms, in which optionally one or more carbon atoms are replaced by O or N; a and b are each 0 or 1, wherein a+b≠2 if no 1,3-diaminoguanidine units are included; R2 is selected from —H and —NH2, wherein R2 is —NH2 if a+b=0, R2 is —H or —NH2 if a+b=1, and R2 is —H if a+b=2; and n≧2. Production methods and uses of the polyguanidine derivatives are also provided.

    Abstract translation: 提供氨基胍和/或1,3-二氨基胍与一种或多种二胺的缩聚产物，包括下式（I）的聚胍衍生物或其盐：其中X选自-NH 2，氨基胍基和1,3-二氨基鸟嘌呤; Y选自-H和-R1-NH2; 或X和Y一起表示化学键以产生环状结构; R1选自具有2至20个碳原子的二价有机基团，其中任选地一个或多个碳原子被O或N替代; a和b各自为0或1，其中a + b≠2，如果不包括1,3-二氨基胍单元; 如果a + b = 0，则R 2选自-H和-NH 2，其中如果a + b = 0，R 2为-NH 2，如果a + b = 1，则R 2为-H 2或如果a + b = 2，则R 2为-H。 n≥2。 还提供了聚胍衍生物的生产方法和用途。

    GUANIDINIUM COMPOUNDS
    13.
    发明申请
    GUANIDINIUM COMPOUNDS 审中-公开
    GUANIDINIUM化合物

    公开(公告)号：US20170001954A1

    公开(公告)日：2017-01-05

    申请号：US15178314

    申请日：2016-06-09

    Applicant: NUtech Ventures

    Inventor： Stephen DiMagno ,  Bao Hu

    IPC: C07C279/08 ,  C07C277/08

    CPC classification number: C07C279/08 ,  C07B59/001 ,  C07C277/08 ,  C07C279/06 ,  C07C309/06

    Abstract: The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also provided.

    Abstract translation: 本申请尤其提供了可用作合成中间体的化合物，所述化合物包含一个或多个胍部分和高价碘原子。 还提供了制备这些化合物的方法。

    Methods for production of high concentration of arginine bicarbonate solution at high pressure
    15.
    发明授权
    Methods for production of high concentration of arginine bicarbonate solution at high pressure 有权
    在高压下生产高浓度精氨酸碳酸氢盐溶液的方法

    公开(公告)号：US09035093B2

    公开(公告)日：2015-05-19

    申请号：US13515829

    申请日：2010-12-13

    Applicant: Donghui Wu

    Inventor： Donghui Wu

    IPC: C07C277/08

    CPC classification number: C07C277/08 ,  C07C279/14

    Abstract: Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.

    Abstract translation: 以非常高的浓度生产精氨酸碳酸氢盐溶液的方法，包括在升高的压力和温度下使包含精氨酸的第一部分的精氨酸浆料与二氧化碳源一起在升高的压力和温度下反应，将后续部分精氨酸加入到所得溶液中，并与压缩的二氧化碳反应 提供包含超过50重量％的最终溶液，其包括通过使精氨酸水浆料升高压力和温度来制备精氨酸溶液，并使精氨酸溶液与二氧化碳气体源反应以形成包含精氨酸和 碳酸氢根阴离子并从溶液中回收精氨酸碳酸氢盐。

    Creatinol sulfate and synthesis method thereof
    17.
    发明申请
    Creatinol sulfate and synthesis method thereof 审中-公开
    硫酸肌酐及其合成方法

    公开(公告)号：US20140256986A1

    公开(公告)日：2014-09-11

    申请号：US13815522

    申请日：2013-03-09

    Applicant: Guoji Zhang

    Inventor： Guoji Zhang

    IPC: C07C277/08

    CPC classification number: C07C279/08

    Abstract: A chemical compound of creatinol sulfate is formed by chemically reacting N-methyl-amino-ethanol, cyanamide, with sulfuric acid to produce the creatinol sulfate with relatively higher yield rate and purity, wherein the mol ratio of N-methyl-amino-ethanol, sulfuric acid, and cyanamide is approximately 2:1:2.

    Abstract translation: 通过N-甲基 - 氨基 - 乙醇，氨基氰与硫酸的化学反应形成硫酸肌酸酐化合物，以相对较高的收率和纯度生产硫酸肌酐，其中N-甲基 - 氨基 - 乙醇， 硫酸和氰胺约为2:1:2。

    4,5-Diamino-3-Halo-2-Hydroxybenzoic Acid Derivatives and Preparations Thereof
    20.
    发明申请
    4,5-Diamino-3-Halo-2-Hydroxybenzoic Acid Derivatives and Preparations Thereof 审中-公开
    4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物及其制备方法

    公开(公告)号：US20120101157A1

    公开(公告)日：2012-04-26

    申请号：US13279519

    申请日：2011-10-24

    Applicant: AN-RONG LEE ,  WEN-HSIN HUANG ,  CHI-HONG CHU ,  WEN-LIANG CHANG ,  CHEN-WEN YAO ,  I-LING CHEN

    Inventor： AN-RONG LEE ,  WEN-HSIN HUANG ,  CHI-HONG CHU ,  WEN-LIANG CHANG ,  CHEN-WEN YAO ,  I-LING CHEN

    IPC: A61K31/245 ,  C07C233/54 ,  C07C231/14 ,  A61P31/16 ,  C07C277/08 ,  C07C279/18 ,  A61K31/196

    CPC classification number: C07C233/54 ,  C07C279/18

    Abstract: Disclosed are 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives and manufactures thereof. The 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives are presented by formula (I): wherein R1 group is H, CH3, or C2H5; R2 group is H, or Br; R3 group is CH3, or C3H7; and R4 group is H, or C(═NH)—NH2. 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives provided here were non-toxic to MDCK cells, particularly compounds 6a, 6b, 6c, 6e, 6f, 7a, 7b and 8 had better anti-H1N1 activity. In the future, these compounds can be used to focus on viral neuraminidases as targets to develop effective anti-influenza drugs.

    Abstract translation: 公开了4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物及其制造方法。 4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物由式（I）表示：其中R 1基团是H，CH 3或C 2 H 5; R2组为H或Br; R3基团是CH3或C3H7; 和R 4基团是H或C（= NH）-NH 2。 本文提供的4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物对MDCK细胞无毒，特别是化合物6a，6b，6c，6e，6f，7a，7b和8具有更好的抗H1N1活性。 未来，这些化合物可用于将病毒性神经氨酸酶作为靶点开发有效的抗流感药物。

Patent Agency Ranking