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1.发明申请METHOD FOR DIAGNOSING KIDNEY DISEASE COMPRISING DETECTING THE LEVEL OF ANNEXIN A2 OR S100A6 审中-公开检测包含ANNEXIN A2或S100A6水平的KIDNEY病的方法公开(公告)号：US20130101998A1
公开(公告)日：2013-04-25
申请号：US13618657
申请日：2012-09-14
Applicant: Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
Inventor： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2800/347
Abstract: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
Abstract translation: 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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2.发明授权Schisandrae fructus extracts for inhibition or prevention of H1N1 influenza virus infection and its application thereof 有权五味子提取物用于抑制或预防H1N1流感病毒感染及其应用公开(公告)号：US08414938B2
公开(公告)日：2013-04-09
申请号：US13298607
申请日：2011-11-17
Applicant: Wen-Liang Chang , Chen-Wen Yao , Chi-Hong Chu , An-Rong Lee , Ann Chen , Wen-Hsin Huang , Kuo-Yuan Hwa , Chiao-Ying Chien , Chien-Yi Pai
Inventor： Wen-Liang Chang , Chen-Wen Yao , Chi-Hong Chu , An-Rong Lee , Ann Chen , Wen-Hsin Huang , Kuo-Yuan Hwa , Chiao-Ying Chien , Chien-Yi Pai
IPC: A01N65/00
CPC classification number: A61K36/79 , A61K31/122 , A61K31/357 , A61K2236/35
Abstract: Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.
Abstract translation: 公开了用于抑制或预防流感及其应用的五味子提取物，其中五味子提取物通过水，甲醇或乙醇提取方法获得，并且提取物包含化合物，例如五味子酮，苯甲酰基乳球菌素P，五味子胺A1，表不见素O， 五味子甙A和枸橼酸甘草聚糖P.提取物和纯化的五味子化合物具有抗流感病毒H1N1和H1N1-TR（达菲药物耐药病毒株）的活性，因此提取物和五味子的纯化化合物可以作为 用于流感感染的治疗或预防剂的药物组合物的生物剂。
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公开(公告)号：US20070154897A1
公开(公告)日：2007-07-05
申请号：US11407101
申请日：2006-04-20
Applicant: Chung-Yang Yen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Ann Chen , Kuo-Yuan Hwa , Chen-Wen Yao , Chao-Wen Cheng , Shun-Min Yang
Inventor： Chung-Yang Yen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Ann Chen , Kuo-Yuan Hwa , Chen-Wen Yao , Chao-Wen Cheng , Shun-Min Yang
CPC classification number: G01N33/6893 , G01N2800/347
Abstract: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
Abstract translation: 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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4.发明授权Method for diagnosing kidney disease comprising detecting the level of annexin A2 有权用于诊断肾脏疾病的方法，包括检测膜联蛋白A2的水平公开(公告)号：US08329410B2
公开(公告)日：2012-12-11
申请号：US12540146
申请日：2009-08-12
Applicant: Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
Inventor： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
CPC classification number: G01N33/6893 , G01N2800/347
Abstract: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
Abstract translation: 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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Patent Agency Ranking
5.发明申请4,5-Diamino-3-Halo-2-Hydroxybenzoic Acid Derivatives and Preparations Thereof 审中-公开4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物及其制备方法公开(公告)号：US20120101157A1
公开(公告)日：2012-04-26
申请号：US13279519
申请日：2011-10-24
Applicant: AN-RONG LEE , WEN-HSIN HUANG , CHI-HONG CHU , WEN-LIANG CHANG , CHEN-WEN YAO , I-LING CHEN
Inventor： AN-RONG LEE , WEN-HSIN HUANG , CHI-HONG CHU , WEN-LIANG CHANG , CHEN-WEN YAO , I-LING CHEN
IPC: A61K31/245 , C07C233/54 , C07C231/14 , A61P31/16 , C07C277/08 , C07C279/18 , A61K31/196
CPC classification number: C07C233/54 , C07C279/18
Abstract: Disclosed are 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives and manufactures thereof. The 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives are presented by formula (I): wherein R1 group is H, CH3, or C2H5; R2 group is H, or Br; R3 group is CH3, or C3H7; and R4 group is H, or C(═NH)—NH2. 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives provided here were non-toxic to MDCK cells, particularly compounds 6a, 6b, 6c, 6e, 6f, 7a, 7b and 8 had better anti-H1N1 activity. In the future, these compounds can be used to focus on viral neuraminidases as targets to develop effective anti-influenza drugs.
Abstract translation: 公开了4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物及其制造方法。 4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物由式（I）表示：其中R 1基团是H，CH 3或C 2 H 5; R2组为H或Br; R3基团是CH3或C3H7; 和R 4基团是H或C（= NH）-NH 2。 本文提供的4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物对MDCK细胞无毒，特别是化合物6a，6b，6c，6e，6f，7a，7b和8具有更好的抗H1N1活性。 未来，这些化合物可用于将病毒性神经氨酸酶作为靶点开发有效的抗流感药物。
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公开(公告)号：US20100081142A1
公开(公告)日：2010-04-01
申请号：US12540146
申请日：2009-08-12
Applicant: Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
Inventor： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
CPC classification number: G01N33/6893 , G01N2800/347
Abstract: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
Abstract translation: 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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7.发明申请SCHISANDRAE FRUCTUS EXTRACTS FOR INHIBITION OR PREVENTION OF H1N1 INFLUENZA VIRUS INFECTION AND ITS APPLICATION THEREOF 有权用于抑制或预防H1N1流感病毒感染的革兰氏阴性菌提取物及其应用公开(公告)号：US20120189719A1
公开(公告)日：2012-07-26
申请号：US13298607
申请日：2011-11-17
Applicant: WEN-LIANG CHANG , CHEN-WEN YAO , CHI-HONG CHU , AN-RONG LEE , ANN CHEN , WEN-HSIN HUANG , KUO-YUAN HWA , CHIAO-YING CHIEN , CHIEN-YI PAI
Inventor： WEN-LIANG CHANG , CHEN-WEN YAO , CHI-HONG CHU , AN-RONG LEE , ANN CHEN , WEN-HSIN HUANG , KUO-YUAN HWA , CHIAO-YING CHIEN , CHIEN-YI PAI
IPC: A61K36/00 , A61K31/343 , A61P31/16 , A61K31/122
CPC classification number: A61K36/79 , A61K31/122 , A61K31/357 , A61K2236/35
Abstract: Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.
Abstract translation: 公开了用于抑制或预防流感及其应用的五味子提取物，其中五味子提取物通过水，甲醇或乙醇提取方法获得，并且提取物包含化合物，例如五味子酮，苯甲酰基乳球菌素P，五味子胺A1，表不见素O， 五味子甙A和枸橼酸甘草聚糖P.提取物和纯化的五味子化合物具有抗流感病毒H1N1和H1N1-TR（达菲药物耐药病毒株）的活性，因此五味子的提取物和纯化的化合物可以作为 用于流感感染的治疗或预防剂的药物组合物的生物剂。
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8.发明申请Herbal Extract Having Anti- Influenza Virus Activity and Preparation of Same 审中-公开草药提取物具有抗流感病毒的活性及其制备方法公开(公告)号：US20080152735A1
公开(公告)日：2008-06-26
申请号：US11963628
申请日：2007-12-21
Applicant: Wen-Liang Chang , Chen-Wen Yao , Ann Chen , Chung-Yang Yen , Li-Shian Shi , Jenn-Han Chen , Ching-Len Liao , Kuo-Yuan Hwa , An-Rong Lee , Po-Huang Liang
Inventor： Wen-Liang Chang , Chen-Wen Yao , Ann Chen , Chung-Yang Yen , Li-Shian Shi , Jenn-Han Chen , Ching-Len Liao , Kuo-Yuan Hwa , An-Rong Lee , Po-Huang Liang
IPC: A61K36/236 , A61K36/00 , A61K36/489 , A61K31/352 , A61P31/12
CPC classification number: A61K36/484 , A61K31/352 , A61K36/236 , A61K36/489
Abstract: The invention provides a herbal extract having anti-influenza virus activity, by extracting Sophora flavescens Ait, Thesium chinense Turcz, licorice, or mixture thereof with solvent. The herbal extract contains at least one compound selected from the group of compounds represented by following formula (I) or (II) or mixture thereof:
Abstract translation: 本发明提供了具有抗流感病毒活性的草药提取物，通过提取苦参，枸杞，甘草或其与溶剂的混合物。 草药提取物含有至少一种选自由下式（I）或（II）表示的化合物或其混合物的化合物：
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公开(公告)号：US20070254290A1
公开(公告)日：2007-11-01
申请号：US11594153
申请日：2006-11-08
Applicant: Chung-Yang Yen , Ann Chen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Chen-Wen Yao , Kuo-Yuan Hwa
Inventor： Chung-Yang Yen , Ann Chen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Chen-Wen Yao , Kuo-Yuan Hwa
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: This invention discloses a method for diagnosing Crescentic glomerulonephritis (CRGN) using at least a sample from a patient. The method is to find a least one biomarker for diagnosing Crescentic glomerulonephritis. The genetic performance of Sparc, Lcn2 and/or Spp1 can be used as biomarkers.
Abstract translation: 本发明公开了一种使用来自患者的至少一个样本来诊断月球性肾小球肾炎（CRGN）的方法。 该方法是找到用于诊断月球性肾小球肾炎的至少一种生物标志物。 Sparc，Lcn2和/或Spp1的遗传表现可用作生物标志物。
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