公开(公告)号：US20200148762A1

公开(公告)日：2020-05-14

申请号：US16185598

申请日：2018-11-09

申请人： Avamab Pharma Inc.

发明人： Laura Van Lieshout ,  Sarah Wootton ,  Bradley G. Thompson

IPC分类号： C07K16/28 ,  C12N15/85 ,  C12N15/62 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  C07K16/20 ,  C07K16/12 ,  A61K47/68

摘要： The present disclosure relates to the composition of one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for upregulating production of two or more antibodies, one or more bi-specific antibodies, or combinations thereof. Embodiments of the present disclosure can be used as a therapy or a treatment of a conditions including: sepsis, parasites, and active and chronic infections caused by bacteria, non-hemorrhagic viruses, amoeba, mycoplasma, fungus, prions or combinations thereof.

公开(公告)号：US10386369B2

公开(公告)日：2019-08-20

申请号：US15877635

申请日：2018-01-23

申请人： WASHINGTON STATE UNIVERSITY

发明人： John F. Alderete

IPC分类号： A61K39/002 ,  G01N33/571 ,  C07K14/44 ,  A61K39/02 ,  A61K39/095 ,  C07K14/20 ,  C07K14/22 ,  C07K16/20

摘要： The invention provides methods and compositions for detecting and diagnosing sexually transmitted infections using a string of epitopes (SOE) specific for detection of causative microorganisms. The antigenic epitopes may be single epitope sequences, a plurality of epitope sequences joined by repeats of glycine (-GG-) and/or lysine (-KK-) to form a series of epitopes (SOE), or nucleotide sequences encoding one or more SOEs and host cells harboring said SOE nucleotide sequences. SOEs specific for highly immunogenic regions of proteins from Trichomonas, Treponema and Neisseria species are provided. SOEs to detect the presence of trichomonas species comprise regions from Trichomonas-sptciric aldolase, GAPDH, a-enolase and a-actinin proteins. Pharmaceutical compositions comprising SOEs can also be used as vaccines or to elicit an immune response to specific microorganisms.

公开(公告)号：US10213502B2

公开(公告)日：2019-02-26

申请号：US15607203

申请日：2017-05-26

申请人： Rhode Island Hospital ,  Seattle Biomedical Research Institute

发明人： Jonathan Kurtis ,  Christian Parcher Nixon ,  Dipak Kumar Raj ,  Jennifer Frances Friedman ,  Michal Fried ,  Patrick Emmet Duffy

IPC分类号： A61K39/002 ,  A61K39/015 ,  A61K39/395 ,  C07K16/44 ,  C07K14/445 ,  C07K16/20 ,  A61K39/00

摘要： The invention provides compositions and methods for preventing or reducing the severity of malaria.

公开(公告)号：US20180258144A1

公开(公告)日：2018-09-13

申请号：US15899428

申请日：2018-02-20

申请人： Molecular Templates, Inc.

发明人： Eric POMA ,  Erin WILLERT ,  Jason KIM ,  Jack HIGGINS

IPC分类号： C07K14/25 ,  C07K16/40 ,  C07K14/245 ,  C07K16/08 ,  C07K16/20 ,  C07K16/32 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K14/25 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/245 ,  C07K16/085 ,  C07K16/20 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/55

摘要： The present invention provides cytotoxic proteins comprising immunoglobulin-type binding regions for mediating cell-type specific targeting and Shiga toxin effector regions derived from A Subunits of members of the Shiga toxin family for effectuating cytotoxicity. The cytotoxic proteins have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections.

公开(公告)号：US20180244759A1

公开(公告)日：2018-08-30

申请号：US15753321

申请日：2016-08-18

申请人： Rutgers, The State University of New Jersey

发明人： Stephen Anderson ,  Elliot Campbell

IPC分类号： C07K16/10 ,  C07K16/06 ,  C07K16/20 ,  C07K1/04 ,  A61K9/00

CPC分类号： C07K16/1045 ,  A61K9/0019 ,  C07K1/047 ,  C07K16/00 ,  C07K16/065 ,  C07K16/205 ,  C07K16/38 ,  C07K2317/14 ,  C07K2317/33 ,  C07K2317/92 ,  Y02A50/58

摘要： The invention describes a method of generating antibodies to a mixture of peptidogenic proteins wherein the peptidogenic protein has altered conformational dynamics as compared to a starting protein and wherein the peptidogenic protein has a similar conformation to the starting protein. The peptidogenic proteins can be used to induce an immune response, which can lead to the generation of antibodies and/or can be used to vaccinate a mammal.

公开(公告)号：US20180230199A1

公开(公告)日：2018-08-16

申请号：US15895636

申请日：2018-02-13

申请人： United States of America, as Represented by the Secretary of Agriculture ,  Arkion Life Sciences, LLC

发明人： Hyun S. Lillehoh ,  Earnest W. Porta ,  Samuel V. Walker ,  Leslie A. Confer ,  Ujvala Deepthi Gadde ,  Cyril Gay

IPC分类号： C07K16/02 ,  C07K16/12 ,  C07K16/20 ,  A61K9/00 ,  A61K47/46 ,  A23K50/75 ,  A23K10/20 ,  A23K10/18 ,  A61P31/04 ,  A61P29/00

摘要： In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens α-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.

公开(公告)号：US20180017557A1

公开(公告)日：2018-01-18

申请号：US15548062

申请日：2016-03-08

申请人： The Regents of the University of California

发明人： Heather Fritz ,  Patricia Conrad

IPC分类号： G01N33/569 ,  C07K16/20

CPC分类号： G01N33/56905 ,  C07K16/20 ,  C07K2317/33 ,  G01N2333/45 ,  G01N2469/10

摘要： The present disclosure provides antibodies that bind the surface of Toxoplasma gondii oocysts, methods for using such antibodies and kits and devices for practicing such methods. Such antibodies, methods, kits and devices find use in detection of T. gondii oocysts and the isolation of such oocysts from samples including environmental samples, food-based samples, diagnostic samples, and the like.

公开(公告)号：US09821046B2

公开(公告)日：2017-11-21

申请号：US14762106

申请日：2014-01-21

申请人： OXFORD UNIVERSITY INNOVATION LIMITED

发明人： Katharine Alice Collins ,  Sarah Catharine Gilbert ,  Adrian Vivian Sinton Hill

IPC分类号： A61K39/15 ,  C07K14/445 ,  A61K39/015 ,  A61K39/12 ,  A61K38/16 ,  C07K16/08 ,  C07K16/20 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K38/162 ,  A61K39/12 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/445 ,  C07K16/082 ,  C07K16/205 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2710/10041 ,  C12N2710/24121 ,  C12N2710/24134 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24171 ,  C12N2730/10134 ,  C12N2730/10171 ,  Y02A50/412

摘要： The present invention provides a particle comprising a fusion protein, wherein the fusion protein comprises at least one NANP repeat (SEQ ID NO: 7), some or all of the C-terminus of the CS protein from Plasmodium falciparum and a hepatitis B surface antigen, and wherein the particle comprises no, or substantially no, free hepatitis B surface antigen protein, and uses thereof.

公开(公告)号：US09764015B2

公开(公告)日：2017-09-19

申请号：US14648538

申请日：2014-04-11

申请人： NATIONAL INSTITUTE OF IMMUNOLOGY ,  INDIAN INSTITUTE OF CHEMICAL BIOLOGY

发明人： Amitabha Mukhopadhyay ,  Syamal Roy ,  Deepika Gupta ,  Rajan Guha ,  Ruchir Rastogi

IPC分类号： C07H21/04 ,  A61K39/008 ,  C07K14/44 ,  G01N33/68 ,  G01N33/569 ,  C07K16/20

CPC分类号： A61K39/008 ,  C07K14/44 ,  C07K16/20 ,  G01N33/56905 ,  G01N33/6893 ,  G01N2333/44 ,  G01N2469/20 ,  Y02A50/41 ,  Y02A50/55

摘要： The present invention in general relates Hemoglobin receptor or its part as a novel vaccine candidate against Leishmaniasis. Specifically, the present invention envisages HbR DNA for eliciting immune response in a mammal against Leishmaniasis. Additional aspect of the present invention is related to a vaccine composition for inducing immune response against Leishmaniasis in mammals. In a preferred aspect, the present invention relates to use of HbR-polypeptide as marker for diagnosis of Leishmania in kala-azar patients.

公开(公告)号：US09603916B2

公开(公告)日：2017-03-28

申请号：US14936309

申请日：2015-11-09

申请人： Isis Innovation Limited

发明人： Alexander Douglas ,  Simon Draper ,  Adrian Hill ,  Andrew Williams ,  Joseph Illingworth

IPC分类号： A61K39/015 ,  C07K16/20 ,  A61K39/39 ,  C07K14/445 ,  C12N15/86 ,  C12N7/00 ,  C12N15/115 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K39/39 ,  A61K2039/507 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/445 ,  C07K16/205 ,  C07K2317/76 ,  C12N7/00 ,  C12N15/115 ,  C12N15/86 ,  C12N2310/16 ,  C12N2710/10341 ,  C12N2710/10371 ,  C12N2710/24141 ,  C12N2710/24171 ,  Y02A50/412

摘要： There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof.