公开(公告)号：US11180523B2

公开(公告)日：2021-11-23

申请号：US16396361

申请日：2019-04-26

Applicant: QuantuMDx Group Limited

Inventor： Jonathan J. O'Halloran ,  Joseph H. Hedley

IPC: C07H19/10 ,  C12Q1/68 ,  C07H19/14 ,  C12Q1/6816 ,  C07H19/048 ,  G01N33/58

Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.

公开(公告)号：US11111264B2

公开(公告)日：2021-09-07

申请号：US16645876

申请日：2018-09-21

Applicant: Chimerix, Inc.

Inventor： Roy W. Ware ,  Venkat Lakshmanan ,  Aaron Leigh Downey

IPC: C07H19/14

Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.

公开(公告)号：US11028116B2

公开(公告)日：2021-06-08

申请号：US17035053

申请日：2020-09-28

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai Liu ,  John Milton ,  Silke Ruediger ,  Xiaolin Wu

IPC: C12Q1/68 ,  C07H19/04 ,  C07H19/16 ,  C07H19/20 ,  C07H19/14 ,  C07H19/06 ,  C07H21/00 ,  C07H19/10 ,  C12Q1/6869 ,  C07H21/04 ,  C12Q1/6874

Abstract: The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10 substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl), T is hydrogen or a C1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).

公开(公告)号：US11008359B2

公开(公告)日：2021-05-18

申请号：US16916887

申请日：2020-06-30

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai Liu ,  John Milton ,  Silke Ruediger ,  Xiaolin Wu

IPC: C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/68

Abstract: The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10 substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl), T is hydrogen or a C1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).

公开(公告)号：US11001603B2

公开(公告)日：2021-05-11

申请号：US17009590

申请日：2020-09-01

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07F9/6561 ,  C07H19/04 ,  A61K31/706 ,  A61K45/06 ,  A61K31/7052 ,  A61K31/7064 ,  C07H19/14

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US10953029B2

公开(公告)日：2021-03-23

申请号：US15761742

申请日：2016-09-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Vinay M. Girijavallabhan

IPC: C07H19/14 ,  A61K31/7064 ,  C07D307/33 ,  A61K45/06 ,  C07H1/00 ,  C07H23/00 ,  C07H19/16 ,  A61P31/18

Abstract: The present invention is directed to 4′-substituted nucleoside derivatives of Formula (I) and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4′-substituted nucleoside derivatives of Formula (I) and derivatives thereof.

公开(公告)号：US20210070798A1

公开(公告)日：2021-03-11

申请号：US16855863

申请日：2020-04-22

Applicant: MILLENNIUM PHARMACEUTICALS, INC.

Inventor： Stephen CRITCHLEY ,  Thomas G. GANT ,  Steven P. LANGSTON ,  Edward J. OLHAVA ,  Stephane PELUSO

IPC: C07H19/16 ,  C07D405/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/14 ,  C07H19/23 ,  C07H19/048

Abstract: This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

公开(公告)号：US20210047357A1

公开(公告)日：2021-02-18

申请号：US17034694

申请日：2020-09-28

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai LIU ,  John MILTON ,  Silke RUEDIGER ,  Xiaolin WU

IPC: C07H19/04 ,  C12Q1/6874 ,  C07H21/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/6869 ,  C07H19/14

Abstract: The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10 substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl), T is hydrogen or a C1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).

公开(公告)号：US10669582B2

公开(公告)日：2020-06-02

申请号：US15915983

申请日：2018-03-08

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Zengmin Li ,  John Robert Edwards ,  Yasuhiro Itagaki

IPC: C12Q1/68 ,  C07H19/14 ,  C12Q1/6869 ,  C07H21/00 ,  C12Q1/686 ,  C12Q1/6874 ,  C12Q1/6872 ,  C07H19/10 ,  C12Q1/6876 ,  C40B40/00

Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

公开(公告)号：US20200087336A1

公开(公告)日：2020-03-19

申请号：US16691108

申请日：2019-11-21

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai LIU ,  John MILTON ,  Silke RUEDIGER

IPC: C07H19/04 ,  C07H19/14 ,  C12Q1/6869 ,  C07H21/00 ,  C07H19/20 ,  C07H19/16 ,  C07H19/10 ,  C07H19/06 ,  C07H21/04 ,  C12Q1/6874

Abstract: The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10 substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl), T is hydrogen or a C1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).