公开(公告)号：US20240091196A1

公开(公告)日：2024-03-21

申请号：US18303267

申请日：2023-04-19

申请人： Bold Therapeutics, Inc.

发明人： Suzanne BAKEWELL ,  Jyothi SETHURAMAN

IPC分类号： A61K31/416 ,  A61K31/555 ,  A61K31/7068 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K31/416 ,  A61K31/555 ,  A61K31/7068 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505

摘要： IT-139, sodium trans-[tetrachlorobis(lH-indazole)ruthenate(III)], is an intravenously administered small molecule compound. In preclinical anti-tumor and mechanism of action studies, IT-139 showed activity against a broad range of tumor types, including those which are resistant to standard anti-cancer agents (e.g., platinums, vinca alkaloids, taxanes, anthracyclines). This activity is believed to arise from 1T-139's novel mechanism of action that targets the GRP78 pathway. It was found that up-regulation of GRP78 is a key cancer cell survival pathway. Downregulation of GRP78 using IT-139 removes this resistance pathway allowing for chemo-therapy and immuno-oncology agents to be more effective in treating cancer.

公开(公告)号：US11850239B2

公开(公告)日：2023-12-26

申请号：US17127131

申请日：2020-12-18

申请人： Ascentage Pharma (Suzhou) Co., Ltd. ,  Ascentage Pharma Group Corp Limited

发明人： Yifan Zhai ,  Dajun Yang

IPC分类号： A61K31/437 ,  A61K31/282 ,  A61P35/00 ,  A61K33/243 ,  A61K31/407 ,  A61K31/555

CPC分类号： A61K31/437 ,  A61K31/282 ,  A61K31/407 ,  A61K31/555 ,  A61K33/243 ,  A61P35/00

摘要： Provided herein is a method of treating, preventing, or alleviating one or more symptoms of a disorder, disease, or condition mediated by an MDM2 with an MDM2 inhibitor, e.g., a compound of Formula (I), and a platinum compound. Also provided herein is a method of inhibiting the growth of a cell with an MDM2 inhibitor and a platinum compound.

公开(公告)号：US20230372333A1

公开(公告)日：2023-11-23

申请号：US18248108

申请日：2021-10-07

申请人： ASTRAZENECA AB

发明人： ELISABETTA LEO

IPC分类号： A61K31/496 ,  A61K33/243 ,  A61K31/555 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K33/243 ,  A61K31/555 ,  A61P35/00

摘要： The present disclosure relates, in general, to therapeutic combinations, and to corresponding methods of treatment, pharmaceutical compositions, and kits.

公开(公告)号：US20230364098A1

公开(公告)日：2023-11-16

申请号：US18117983

申请日：2023-03-06

申请人： G1 Therapeutics, Inc.

发明人： Jay Copeland Strum ,  John Emerson Bisi ,  Patrick Joseph Roberts ,  Francis X. Tavares

IPC分类号： A61K31/527 ,  C07D487/14 ,  A61K45/06 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/04 ,  A61P35/00 ,  A61K9/00 ,  A61K31/555 ,  A61K31/7048

CPC分类号： A61K31/527 ,  C07D487/14 ,  A61K45/06 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/04 ,  A61P35/00 ,  A61K9/0053 ,  A61K31/555 ,  A61K31/7048

摘要： This invention is in the area of improved compounds for and methods of treating selected RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders while minimizing the deleterious effects on healthy cells, for example healthy Hematopoietic Stem Cells and Progenitor Cells (HSPCs), associated with current treatment modalities. In one aspect, improved treatment of select RB-positive cancers is disclosed using specific compounds disclosed herein. In certain embodiments, the compounds described herein act as highly selective and, in certain embodiments, short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects.

公开(公告)号：US11744834B2

公开(公告)日：2023-09-05

申请号：US16837342

申请日：2020-04-01

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Okhil Nag ,  Gregory Ellis ,  Scott Walper ,  Jeffrey R. Deschamps ,  D. Andrew Knight ,  James B. Delehanty

IPC分类号： A61K31/555 ,  A61P25/36 ,  A61K47/69

CPC分类号： A61K31/555 ,  A61K47/6929 ,  A61P25/36

摘要： A rhodium-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with rhodium, effectively neutralizes the biological activity of naturally-occurring and synthetic opioids.

公开(公告)号：US11730826B2

公开(公告)日：2023-08-22

申请号：US15584309

申请日：2017-05-02

申请人： Massachusetts Institute of Technology

发明人： Paiman Peter Ghoroghchian ,  Haihua Xiao ,  Ruogu Qi ,  Ting Li

IPC分类号： A61K9/00 ,  A61K48/00 ,  A61K47/60 ,  A61K47/64 ,  C12N15/113 ,  A61K33/243 ,  A61K47/69 ,  A61K31/555 ,  C08G81/00 ,  C12N15/11 ,  A61K9/107 ,  A61K31/282 ,  A61K47/34 ,  C07K2/00 ,  C08G69/10 ,  C12N15/90 ,  A61K47/10 ,  A61K39/00 ,  C12N15/09 ,  G01N21/47

CPC分类号： A61K48/0041 ,  A61K9/107 ,  A61K31/282 ,  A61K31/555 ,  A61K33/243 ,  A61K47/10 ,  A61K47/34 ,  A61K47/60 ,  A61K47/646 ,  A61K47/6907 ,  A61K47/6935 ,  A61K48/005 ,  C07K2/00 ,  C08G69/10 ,  C08G81/00 ,  C12N15/11 ,  C12N15/113 ,  C12N15/90 ,  A61K2039/585 ,  C12N15/09 ,  C12N2310/20 ,  G01N21/47

摘要： Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.

公开(公告)号：US20230218755A1

公开(公告)日：2023-07-13

申请号：US18183467

申请日：2023-03-14

申请人： Genentech, Inc.

发明人： Gwendolyn FYFE ,  Eric HOLMGREN ,  Robert D. MASS ,  William NOVOTNY

IPC分类号： A61K39/395 ,  C07K16/22 ,  A61K31/525 ,  A61K31/519 ,  C07K16/30 ,  A61K31/4545 ,  A61K9/00 ,  A61K38/50 ,  A61K31/337 ,  A61K31/282 ,  A61K38/09 ,  A61K31/555 ,  A61K31/522 ,  A61K31/573 ,  A61K38/21 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/4745 ,  A61K45/06 ,  A61K39/00

CPC分类号： A61K39/3955 ,  C07K16/22 ,  A61K31/525 ,  A61K31/519 ,  C07K16/3046 ,  A61K31/4545 ,  A61K9/0019 ,  A61K39/39541 ,  A61K38/50 ,  A61K31/337 ,  A61K31/282 ,  A61K38/09 ,  A61K31/555 ,  A61K31/522 ,  A61K31/573 ,  A61K38/212 ,  A61K31/513 ,  A61K31/7068 ,  A61K39/39558 ,  A61K31/4745 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/567 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/21

摘要： This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.

公开(公告)号：US20230190991A1

公开(公告)日：2023-06-22

申请号：US18112192

申请日：2023-02-21

申请人： TERUMO CORPORATION

发明人： Gregory M. Cruise ,  Xinping Wu ,  Gloria Hincapie ,  Yue Wu

IPC分类号： A61L24/00 ,  A61L26/00 ,  A61K47/69 ,  A61K31/4745 ,  A61K31/555 ,  A61L24/06 ,  C08F220/56 ,  A61L31/04 ,  A61L31/14 ,  C08F236/20

CPC分类号： A61L24/0015 ,  A61L26/009 ,  A61L26/0014 ,  A61L26/0061 ,  A61K47/6927 ,  A61K31/4745 ,  A61K31/555 ,  A61L24/0042 ,  A61L24/06 ,  C08F220/56 ,  A61L31/048 ,  A61L31/148 ,  C08F236/20 ,  A61L2400/06 ,  A61B17/12109

摘要： Described are polymers and methods of forming and using same.

公开(公告)号：US11672796B2

公开(公告)日：2023-06-13

申请号：US17132547

申请日：2020-12-23

申请人： PHARNEXT

发明人： Daniel Cohen ,  Serguei Nabirochkin ,  Ilya Chumakov

IPC分类号： A61K31/047 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/436 ,  A61K31/439 ,  A61K31/555 ,  A61K31/567 ,  A61K31/575 ,  A61K31/7004 ,  A61K45/06 ,  A61K31/485 ,  A61K9/00

CPC分类号： A61K31/485 ,  A61K9/0053 ,  A61K31/047 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/436 ,  A61K31/439 ,  A61K31/555 ,  A61K31/567 ,  A61K31/575 ,  A61K31/7004 ,  A61K45/06 ,  A61K31/192 ,  A61K2300/00 ,  A61K31/197 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00 ,  A61K31/4178 ,  A61K2300/00 ,  A61K31/436 ,  A61K2300/00 ,  A61K31/485 ,  A61K2300/00 ,  A61K31/575 ,  A61K2300/00 ,  A61K31/7004 ,  A61K2300/00 ,  A61K31/567 ,  A61K2300/00 ,  A61K31/047 ,  A61K2300/00 ,  A61K31/555 ,  A61K2300/00 ,  A61K31/195 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.

公开(公告)号：US20230149500A1

公开(公告)日：2023-05-18

申请号：US17735776

申请日：2022-05-03

申请人： Medivir AB

发明人： Stephen M. CONDON ,  Yijun DENG ,  Matthew G. LAPORTE ,  Susan R. RIPPIN

IPC分类号： A61K38/05 ,  C07D403/06 ,  C07K5/062 ,  A61P35/00 ,  A61P35/04 ,  A61K38/07 ,  A61K45/06 ,  C07D403/14 ,  C07K5/02 ,  A61K31/404 ,  A61N5/06 ,  A61N5/10 ,  C07K5/06 ,  C12N5/09 ,  A61K31/555

CPC分类号： A61K38/05 ,  A61K31/404 ,  A61K31/555 ,  A61K38/07 ,  A61K45/06 ,  A61N5/10 ,  A61N5/062 ,  A61P35/00 ,  A61P35/04 ,  C07D403/06 ,  C07D403/14 ,  C07K5/02 ,  C07K5/06 ,  C07K5/06026 ,  C12N5/0693 ,  A61K38/00 ,  Y02P20/55

摘要： A SMAC mimetic and pharmaceutical compositions thereof and methods of use.