公开(公告)号：US20240024266A1

公开(公告)日：2024-01-25

申请号：US18036998

申请日：2021-11-16

申请人： Hiroshima University ,  Tokyo University of Pharmacy & Life Sciences ,  The University of Tokyo

发明人： Tomoichiro Asano ,  Takemasa Sakaguchi ,  Takeshi Yamamotoya ,  Yusuke Nakatsu ,  Hisanaka Ito ,  Takayoshi Okabe ,  Jeffrey Encinas

IPC分类号： A61K31/196 ,  A61P31/14 ,  A61K31/47 ,  A61K31/403 ,  A61K31/357 ,  A61K31/198 ,  A61K31/216 ,  A61K31/538 ,  A61K31/235 ,  A61K31/341 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4045 ,  A61K31/27 ,  A61K31/194 ,  A61K31/192 ,  A61K31/683 ,  A61K31/4035 ,  A61K31/197 ,  A61K31/36 ,  A61K31/4406 ,  A61K31/245 ,  A61K31/472 ,  A61K31/444

CPC分类号： A61K31/196 ,  A61P31/14 ,  A61K31/47 ,  A61K31/403 ,  A61K31/357 ,  A61K31/198 ,  A61K31/216 ,  A61K31/538 ,  A61K31/235 ,  A61K31/341 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4045 ,  A61K31/27 ,  A61K31/194 ,  A61K31/192 ,  A61K31/683 ,  A61K31/4035 ,  A61K31/197 ,  A61K31/36 ,  A61K31/4406 ,  A61K31/245 ,  A61K31/472 ,  A61K31/444

摘要： [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections.
[Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US11872199B2

公开(公告)日：2024-01-16

申请号：US18152034

申请日：2023-01-09

申请人： SMARTECH TOPICAL, INC.

发明人： Thomas Hnat

IPC分类号： A61K31/196 ,  A61K9/14 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/405 ,  A61K31/416 ,  A61K31/60 ,  A61K31/7034 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/38 ,  A61K9/00

CPC分类号： A61K31/196 ,  A61K9/0014 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/405 ,  A61K31/416 ,  A61K31/60 ,  A61K31/7034 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/38

摘要： A topical cyclooxygenase (COX) inhibitor formulation comprising an inhibitor of COX-1 and/or COX-2, one or more long chain monounsaturated fatty acids, long chain monounsaturated fatty alcohols, terpenes, or combinations thereof; and a solvent mixture comprising ethanol, propylene glycol, 2-(2-Ethoxyethoxy)ethanol, and optionally dimethylsulfoxide.

公开(公告)号：US11844837B2

公开(公告)日：2023-12-19

申请号：US17209078

申请日：2021-03-22

申请人： Heron Therapeutics, Inc.

发明人： Thomas B. Ottoboni ,  Lee Ann Lynn Girotti

IPC分类号： A61K47/34 ,  A61K31/445 ,  A61K47/12 ,  A61K9/00 ,  A61K31/245 ,  A61K31/47 ,  A61K31/167 ,  A61K31/00

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/445 ,  A61K31/47 ,  A61K47/12

摘要： Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an organic acid excipient, and a basic drug are described, along with related methods.

公开(公告)号：US11806337B2

公开(公告)日：2023-11-07

申请号：US17875216

申请日：2022-07-27

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Stephen Gardell ,  Anthony B. Pinkerton ,  Eduard Sergienko ,  Hampton Sessions

IPC分类号： A61K31/4409 ,  A61K31/196 ,  A61K31/245 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/5386 ,  C07C275/42 ,  C07D213/40 ,  C07D213/56 ,  C07D213/643 ,  C07D213/73 ,  C07D213/74 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D249/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D498/08

CPC分类号： A61K31/4409 ,  A61K31/196 ,  A61K31/245 ,  A61K31/415 ,  A61K31/417 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/5386 ,  C07C275/42 ,  C07D213/40 ,  C07D213/56 ,  C07D213/643 ,  C07D213/73 ,  C07D213/74 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D249/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D498/08

摘要： Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

公开(公告)号：US11752217B2

公开(公告)日：2023-09-12

申请号：US17726944

申请日：2022-04-22

申请人： Viking Scientific, Inc.

发明人： Paul Fisher ,  Paulina Davis

IPC分类号： A61K47/69 ,  A61K47/60 ,  A61K47/55 ,  A61K47/59 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/245 ,  A61K31/522 ,  A61K31/555 ,  A61K31/606 ,  A61K31/675 ,  A61K31/704 ,  A61K47/34 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K9/70 ,  A61K45/06 ,  A61K47/08

CPC分类号： A61K47/6903 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/14 ,  A61K9/7007 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/245 ,  A61K31/522 ,  A61K31/555 ,  A61K31/606 ,  A61K31/675 ,  A61K31/704 ,  A61K45/06 ,  A61K47/08 ,  A61K47/34 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60

摘要： Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

公开(公告)号：US20230270709A1

公开(公告)日：2023-08-31

申请号：US18043609

申请日：2021-09-02

申请人： Christian-Albrechts-Universitat Zu Kiel

发明人： Dennis Schade ,  Regina Scherliess ,  Bernd Clement

IPC分类号： A61K31/245 ,  A61K9/00

CPC分类号： A61K31/245 ,  A61K9/0014

摘要： The present invention relates to a topical pharmaceutical composition comprising a serine protease inhibitor for use in the treatment or prevention of viral infections. The invention is further directed to serine protease inhibitors and a lozenge and a dry nasal preparation comprising the serine protease inhibitor.

公开(公告)号：US11738031B2

公开(公告)日：2023-08-29

申请号：US17399490

申请日：2021-08-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Helen M. Blau ,  Adelaida R. Palla ,  Andrew Tri Van Ho

IPC分类号： A61K31/00 ,  A61K31/5575 ,  A61K45/06 ,  A61K38/17 ,  A61K35/64 ,  A61K35/583 ,  A61P21/06 ,  A61K31/167 ,  A61K31/245 ,  A61K31/46 ,  A61K31/47 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/32 ,  A61K38/46 ,  A61P21/00 ,  A61K9/00 ,  A61K31/445

CPC分类号： A61K31/5575 ,  A61K9/0019 ,  A61K31/167 ,  A61K31/245 ,  A61K31/445 ,  A61K31/46 ,  A61K31/47 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/32 ,  A61K35/583 ,  A61K35/64 ,  A61K38/1703 ,  A61K38/465 ,  A61K45/06 ,  A61P21/00 ,  A61P21/06 ,  A61K38/1703 ,  A61K2300/00 ,  A61K31/5575 ,  A61K2300/00 ,  A61K31/445 ,  A61K2300/00 ,  A61K35/583 ,  A61K2300/00 ,  A61K35/64 ,  A61K2300/00

摘要： Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

公开(公告)号：US20230248685A1

公开(公告)日：2023-08-10

申请号：US18306483

申请日：2023-04-25

申请人： BETAHEALTH LLC

发明人： Pablo Antonio BETANCOURT

IPC分类号： A61K31/245 ,  A61K38/06 ,  A61P11/00 ,  A61K38/46

CPC分类号： A61K31/245 ,  A61K38/063 ,  A61P11/00 ,  A61K38/465 ,  C12Y301/21001

摘要： Described herein is a composition and methods for treating, reducing the symptoms of, or prophylaxis of viral infections, and particularly SARS-CoV-2. The composition enhances delivery of oxygen to the tissues. Also described herein is a composition and methods for treating cancers, particularly, adenocarcinomas, infiltrating ductal adenocarcinoma, metastatic ductal adenocarcinoma, and neuroendocrine tumors. The composition inhibits the growth of tumor cells and promotes cytoreduction of tumors.

公开(公告)号：US20230233504A1

公开(公告)日：2023-07-27

申请号：US18158792

申请日：2023-01-24

申请人： Ventis Pharma

发明人： Jeremy POULSEN ,  Louis STANFIELD ,  Lawrence VOLZ

IPC分类号： A61K31/245 ,  A61J1/20 ,  A61K31/137 ,  A61K31/573 ,  A61K45/06 ,  A61K47/02 ,  B65D81/32

CPC分类号： A61K31/245 ,  A61J1/2093 ,  A61K31/137 ,  A61K31/573 ,  A61K45/06 ,  A61K47/02 ,  B65D81/3266 ,  A61K9/08

摘要： An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.

公开(公告)号：US20230190697A1

公开(公告)日：2023-06-22

申请号：US17995020

申请日：2021-03-31

申请人： ENSYSCE BIOSCIENCES, INC.

发明人： Lynn KIRKPATRICK

IPC分类号： A61K31/245 ,  A61P31/14

CPC分类号： A61K31/245 ,  A61P31/14 ,  A61K9/0053

摘要： Compositions and methods that can be used to treat or prevent a viral infection are described herein. For example, pharmaceutical compositions containing nafamostat mesylate may be used to treat infection by SARS-CoV-2 (“COVID-19”). Oral administration of nafamostat mesylate may be effective to reduce viral load in the gastrointestinal tract and reduce related GI symptoms.