公开(公告)号：US08373119B2

公开(公告)日：2013-02-12

申请号：US13561365

申请日：2012-07-30

Applicant: Peter T. A. Reilly

Inventor： Peter T. A. Reilly

IPC: H01J49/40

CPC classification number: H01J49/04 ,  H01J49/0445 ,  H01J49/0481 ,  H01J49/161

Abstract: An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios.

Abstract translation: 气溶胶粒子分析仪包括激光烧蚀室，充气管道和质谱仪。 激光烧蚀室可以在低压下操作，其可以为0.1mTorr至30mTorr。 将烧蚀的离子转移到充气管道中。 充气导管减少了电荷和消融离子的速度，因为它们与气体填充导管中的缓冲气体碰撞并混合。 优选地，气体填充导管包括电磁多极结构，其将新生离子准直成束，其被引导到质谱仪中。 由于气体填充的管道允许从烧蚀的颗粒中储存大量的离子，可以多次分析来自单个消融颗粒的离子，并通过各种技术分析组成和同位素比率的统计学上有意义的分析。

公开(公告)号：US20130026359A1

公开(公告)日：2013-01-31

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/26 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US20110287550A1

公开(公告)日：2011-11-24

申请号：US13114516

申请日：2011-05-24

Applicant: Jentaie Shiea ,  Chu-Nian Cheng

Inventor： Jentaie Shiea ,  Chu-Nian Cheng

IPC: G01N33/52 ,  G01N21/00

CPC classification number: H01J49/165 ,  H01J49/0431 ,  H01J49/161 ,  Y10T436/143333

Abstract: The present invention provides a system and method for real-time continuously monitoring of oligonucleotide synthesis in solution phase.

Abstract translation: 本发明提供了一种用于实时连续监测溶液相中寡核苷酸合成的系统和方法。

公开(公告)号：US20090321627A1

公开(公告)日：2009-12-31

申请号：US11721832

申请日：2005-12-15

Applicant: Bernd Abel ,  Jürgen Troe ,  Ales Charvat

Inventor： Bernd Abel ,  Jürgen Troe ,  Ales Charvat

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/161 ,  H01J49/04

Abstract: The invention relates to a test method, especially for mass spectroscopy of biomolecules, including the following steps: one or several samples (2-4) that are to be analyzed are introduced into a carrier liquid of a micro liquid jet (1) in rapid succession; at least some of the samples (2-4) are desorbed from the micro liquid jet (1); and the sample (2-4) that is desorbed from the micro liquid jet (1) is analyzed. According to the invention, the sample (2-4) is spatially delimited in the spraying direction in the micro liquid jet (1) while extending only along a subarea of the micro liquid jet (1) in the spraying direction.

Abstract translation: 本发明涉及一种特别用于生物分子的质谱法的测试方法，其包括以下步骤：将要分析的一种或几种样品（2-4）快速引入微液体射流（1）的载体液体中 演替; 至少一些样品（2-4）从微液体射流（1）中解吸; 并且分析从微液体射流（1）解吸的样品（2-4）。 根据本发明，样品（2-4）在微液体射流（1）中在喷射方向上在空间上被界定，同时沿着喷雾方向的微液体射流（1）的分区延伸。

公开(公告)号：US20090071815A1

公开(公告)日：2009-03-19

申请号：US11596769

申请日：2005-05-17

Applicant: Atsushi Takamizawa ,  Sunner Jan Arne

Inventor： Atsushi Takamizawa ,  Sunner Jan Arne

IPC: B01J19/12 ,  B01D57/02

CPC classification number: H01J49/165 ,  G01N1/44 ,  H01J49/0059 ,  H01J49/161 ,  Y10T436/24

Abstract: A biological sample solution is ionized by electrospray and the sample solution is irradiated with an infrared laser beam to dissociate biological macromolecules into the constituents thereof. As a result, only non-covalent bonds of the biological macromolecules can be selectively severed and analyzed.

Abstract translation: 通过电喷雾离子化生物样品溶液，并用红外激光束照射样品溶液以将生物大分子解离成其组分。 结果，只能选择性地切断和分析生物大分子的非共价键。

公开(公告)号：US07109479B2

公开(公告)日：2006-09-19

申请号：US10952529

申请日：2004-09-28

Applicant: Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

Inventor： Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/063 ,  H01J49/0481 ,  H01J49/161 ,  H01J49/164

Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

公开(公告)号：US4023038A

公开(公告)日：1977-05-10

申请号：US507583

申请日：1974-09-19

Applicant: George Sargent Janes ,  Charles T. Pike

Inventor： George Sargent Janes ,  Charles T. Pike

IPC: B01D59/34 ,  H01J49/16 ,  H01J39/34

CPC classification number: H01J49/14 ,  B01D59/34 ,  H01J49/161

Abstract: A system employing multiple, upper excitation levels in a technique for isotopically selective ionization to improve the ionization efficiency. In a technique which employs laser radiation to excite particles with isotopic selectivity, excitation is produced to a plurality of excited states below the ionization level with the result of increasing the number of available excited particles for ionization and thereby increasing the ionization cross-section for improved system efficiency.

Abstract translation: 一种在同位素选择性电离技术中采用多个较高激发水平以提高电离效率的系统。 在使用激光辐射以同位素选择性激发颗粒的技术中，产生了低于电离水平的多个激发态的激发，结果是增加用于电离的可用激发粒子的数量，从而增加电离横截面以改善 系统效率。

公开(公告)号：US3294970A

公开(公告)日：1966-12-27

申请号：US23320462

申请日：1962-10-24

Applicant: LUDOLF JENCKEL

Inventor： LUDOLF JENCKEL

IPC: H01J17/00 ,  H01J49/16 ,  H01J49/18

CPC classification number: H01J49/18 ,  H01J17/00 ,  H01J49/161 ,  H01J2893/0059

公开(公告)号：US11651945B2

公开(公告)日：2023-05-16

申请号：US17480094

申请日：2021-09-20

Applicant: UT-Battelle, LLC

Inventor： Vilmos Kertesz ,  John F. Cahill

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  H01J49/14 ,  H01J49/10

CPC classification number: H01J49/0445 ,  H01J49/0031 ,  H01J49/105 ,  H01J49/145 ,  H01J49/161 ,  H01J49/165

Abstract: A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.

公开(公告)号：US20180275098A1

公开(公告)日：2018-09-27

申请号：US15323317

申请日：2015-11-26

Applicant: Korea Basic Science Institute

Inventor： Myoung Choul CHOI ,  Jeong-Hoon KANG ,  Jung-Hwan KIM

IPC: G01N27/62 ,  G01N27/64 ,  H01J49/00 ,  H01J49/16

CPC classification number: G01N27/622 ,  G01N27/64 ,  H01J49/0036 ,  H01J49/161

Abstract: Provided are an apparatus for measuring an ionic mobility of a harmful material and a reference data obtaining method thereof. The method includes obtaining a measurement signal by detecting a charge of an ion between electrodes, obtaining a noise signal by insulating the electrodes from the ion, aligning the noise signal with the measurement signal, removing a part of the measurement signal aligned with the noise signal, and calculating reference data from a remaining part of the measurement signal.