公开(公告)号：US20230149431A1

公开(公告)日：2023-05-18

申请号：US17916382

申请日：2021-04-02

申请人： BIOPRONEO B.V.

发明人： Edwin SPAANS ,  Martin Han Kuang Erwin GOUW ,  Floris Jan VAN BREDERODE ,  Mirena NOUWEN

IPC分类号： A61K31/7004 ,  A61K9/02 ,  A61K41/10 ,  A61K47/12 ,  A61K47/38

CPC分类号： A61K31/7004 ,  A61K9/02 ,  A61K41/10 ,  A61K47/12 ,  A61K47/38

摘要： The invention relates to a method for producing a composition, in particular a gel composition, more in particular a glucose gel, the method comprising the steps of providing an aqueous glucose solution, adding at least one first fraction of acid, adding a fraction of a gelling agent and mixing of the solution and gelling agent such that a composition is obtained. A container is subsequently filled with said composition.

公开(公告)号：US20180273586A1

公开(公告)日：2018-09-27

申请号：US15918047

申请日：2018-03-12

申请人： SYNERGY PHARMACEUTICALS, INC.

发明人： Kunwar SHAILUBHAI ,  Gary S. JACOB

IPC分类号： C07K7/08 ,  A61K47/60 ,  A61K31/192 ,  A61K31/519 ,  A61K45/06 ,  A61K9/00 ,  C07K7/64 ,  A61K47/02 ,  A61K38/10 ,  A61K9/02 ,  A61K38/12 ,  A61K9/08

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64 ,  H05K999/99

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

公开(公告)号：US10016358B2

公开(公告)日：2018-07-10

申请号：US14496737

申请日：2014-09-25

申请人： Bjorn Andersch

发明人： Bjorn Andersch

IPC分类号： A61K9/00 ,  A61K9/02 ,  A61K31/19 ,  A61K47/02 ,  A61K47/34

CPC分类号： A61K9/0034 ,  A61K9/02 ,  A61K31/19 ,  A61K47/02 ,  A61K47/34 ,  Y10S514/967

摘要： The present invention relates to a vaginal suppository comprising an inert vehicle and lactic acid or a salt thereof for the treatment and/or prophylaxis of disorders in the urogenital tract.It also relates to the use of such a suppository for the production of a medicament for the treatment and/or prophylaxis of disorders in the urogenital tract as well as to a method for the treatment and/or prophylaxis of disorders in the urogenital tract.

公开(公告)号：US20180133250A1

公开(公告)日：2018-05-17

申请号：US15865995

申请日：2018-01-09

申请人： CDA Research Group, Inc.

发明人： Dominic C. ABBOTT ,  ChunLim ABBOTT

IPC分类号： A61K33/34 ,  A61Q11/00 ,  A01M31/00 ,  A61K9/12 ,  A61K9/06 ,  A61K9/02 ,  A61K9/00 ,  A61Q17/00 ,  A61K9/70 ,  A61K9/10 ,  A61K9/08 ,  A61K8/19

CPC分类号： A61K33/34 ,  A01M31/00 ,  A61K8/19 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/006 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/122 ,  A61K9/7084 ,  A61Q11/00 ,  A61Q17/005

摘要： Provided herein are topical formulations containing copper ions and methods of treating inflammatory, microbial, and arthritic conditions in various areas of the body using such formulations. Methods of treating osteoarthritis using topical copper ion treatments are provided. Methods of treating and preventing microbial infections using copper ion treatments are further provided, including methods of preventing biofilm. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.

公开(公告)号：US09962347B2

公开(公告)日：2018-05-08

申请号：US15062156

申请日：2016-03-06

申请人： Naeem Uddin

发明人： Naeem Uddin

IPC分类号： A61K31/194 ,  A61K31/56 ,  A61K31/573 ,  A61K31/60 ,  A61K33/30 ,  A61K47/00 ,  A61K8/19 ,  A61K8/27 ,  A61K8/368 ,  A61K8/63 ,  A61K9/00 ,  A61K33/00 ,  A61Q19/02 ,  A61K8/362 ,  A61K8/365 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61K9/02 ,  A61K33/32

CPC分类号： A61K31/194 ,  A61K8/19 ,  A61K8/27 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/63 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/02 ,  A61K31/56 ,  A61K31/573 ,  A61K31/60 ,  A61K33/00 ,  A61K33/30 ,  A61K33/32 ,  A61K47/00 ,  A61K2800/5922 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/02 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/491 ,  A61K2300/00

摘要： A pharmacological composition for the treatment of bacterial and protozoal infections in a patient. The preferred pharmacological composition comprises a pharmaceutical carrier and an active composition selected from the group consisting of: a) an amount of sodium oxalate and an amount of oxalic acid, b) an amount of sodium citrate and an amount of citric acid, or c) mixtures of a) and b). The amounts and weight ratios of a) the sodium oxalate and oxalic acid, and b) the sodium citrate and citric acid in the active composition are such as to produce a safe and effective pharmacological composition. Sodium salts of other carboxylic acids may be used. The invention also relates to the method of using the pharmacological composition for the safe and effective treatment of bacterial infections, protozoal infections and dermatological diseases.

公开(公告)号：US20180110867A1

公开(公告)日：2018-04-26

申请号：US15848987

申请日：2017-12-20

申请人： JenKem Technology Co., Ltd. (Tianjin)

发明人： Jinliang Wang ,  Zewang Feng ,  Hui Zhu ,  Meina Lin ,  Yan Liu ,  Xuan Zhao

IPC分类号： A61K47/60 ,  A61K47/10 ,  A61K47/18 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K9/70

CPC分类号： A61K47/60 ,  A61K9/00 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/70 ,  A61K47/10 ,  A61K47/186

摘要： A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.

公开(公告)号：US20180110753A1

公开(公告)日：2018-04-26

申请号：US15787978

申请日：2017-10-19

申请人： AXIM Biotechnologies, Inc.

发明人： Lekhram CHANGOER ,  George ANASTASSOV

IPC分类号： A61K31/352 ,  A61K9/02 ,  A61K47/10

CPC分类号： A61K31/352 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/025 ,  A61K47/10

摘要： This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.

公开(公告)号：US09907787B2

公开(公告)日：2018-03-06

申请号：US15450590

申请日：2017-03-06

申请人： EMERAMED LIMITED

发明人： Boyd E. Haley

IPC分类号： A61K31/44 ,  A61K31/166 ,  A61K9/00 ,  A61K9/02 ,  A61K45/06 ,  A23L33/10

CPC分类号： A61K31/44 ,  A23L33/10 ,  A23L33/13 ,  A23L33/175 ,  A23L33/19 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/02 ,  A61K31/16 ,  A61K31/166 ,  A61K31/355 ,  A61K31/385 ,  A61K31/59 ,  A61K31/7076 ,  A61K45/06

摘要： A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of an active compound having the chemical structure: where n=1-4 and X is selected from the group consisting of hydrogen, lithium sodium, potassium, rubidium, cesium and francium.

公开(公告)号：US20180042859A1

公开(公告)日：2018-02-15

申请号：US15715425

申请日：2017-09-26

申请人： Purdue Pharma L.P.

发明人： Benjamin Oshlack ,  Curtis Wright ,  J. David Haddox

IPC分类号： A61K9/50 ,  A61K9/20 ,  A61K9/48 ,  A61K31/485 ,  A61K9/00

CPC分类号： A61K9/5084 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/02 ,  A61K9/14 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1676 ,  A61K9/1694 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2866 ,  A61K9/4808 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5078 ,  A61K9/51 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/485

摘要： Oral dosage forms containing an opioid antagonist in a sequestered form are described. The opioid antagonist is sequestered such that it is not released or substantially not released in the gastrointestinal tract from the dosage form which is administered orally intact. However, when the dosage form is chewed, crushed, heated or dissolved in a solvent, and then administered orally, intranasally, parenterally or sublingually, the opioid antagonist is released and at least partially blocks effects of the opioid agonist.

公开(公告)号：US20170368123A1

公开(公告)日：2017-12-28

申请号：US15544568

申请日：2016-01-19

申请人： REPOLAR PHARMACEUTICALS OY

发明人： Pentti SIPPONEN

IPC分类号： A61K36/13 ,  A61K9/00 ,  A61K9/02 ,  A61K9/08 ,  A61K9/06

CPC分类号： A61K36/13 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K36/15 ,  A61K47/10 ,  A61K47/44

摘要： The invention relates to an anti-inflammatory agent comprising coniferous resin acids and to pharmaceutical formulations containing said agent for use in treating and preventing sterile inflammation.