公开(公告)号：US20220281943A1

公开(公告)日：2022-09-08

申请号：US17635054

申请日：2020-08-10

申请人： The Regents of the University of California

发明人： Jeffrey A. Bluestone ,  Caroline Raffin

IPC分类号： C07K14/725 ,  C12N5/0783 ,  C07K16/18

摘要： Chimeric antigen receptor (CAR)-expressing Tregs specifically target modified protein or proteins present in the extra cellular matrix of an inflammatory lesion of patients to induce a localized and effective immunosuppressive response.

公开(公告)号：US11435349B2

公开(公告)日：2022-09-06

申请号：US15958638

申请日：2018-04-20

申请人： The Regents of the University of California

发明人： Jeffrey A. Bluestone ,  Weihong Liu ,  Amy Putnam

IPC分类号： C12N5/0783 ,  G01N33/569 ,  A61K39/00 ,  G01N33/50 ,  A61K35/17 ,  A61K35/12

摘要： The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.

公开(公告)号：US20180238880A1

公开(公告)日：2018-08-23

申请号：US15958638

申请日：2018-04-20

申请人： The Regents of the University of California

发明人： Jeffrey A. Bluestone ,  Weihong Liu ,  Amy Putnam

IPC分类号： G01N33/569 ,  A61K39/00 ,  G01N33/50 ,  C12N5/0783 ,  A61K35/17 ,  A61K35/12

CPC分类号： G01N33/56972 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/122 ,  A61K2039/515 ,  C12N5/0636 ,  G01N33/505 ,  G01N2333/70514 ,  G01N2333/70517 ,  G01N2333/70596 ,  G01N2333/7155

摘要： The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.

公开(公告)号：US09211328B2

公开(公告)日：2015-12-15

申请号：US13797921

申请日：2013-03-12

申请人： The Regents of the University of California

发明人： Lewis L. Lanier ,  Koetsu Ogasawara ,  Jeffrey A. Bluestone

IPC分类号： A61K39/40 ,  A61K35/28 ,  A01N25/00 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： A61K39/39541 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2316/96 ,  C07K2317/73 ,  C07K2317/76 ,  Y10S514/885

摘要： The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

摘要翻译： 本发明涉及用于治疗和/或预防自身免疫和/或炎性疾病的方法和组合物。 特别地，本发明提供了通过调节NKG2D来损害自身反应性T细胞，NK细胞和/或NKT细胞的扩增和功能的治疗剂。

公开(公告)号：US20150192582A1

公开(公告)日：2015-07-09

申请号：US14666772

申请日：2015-03-24

申请人： The Regents of the University of California

发明人： Jeffrey A. Bluestone ,  Weihong Liu ,  Amy Putnam

IPC分类号： G01N33/569 ,  A61K35/17

CPC分类号： G01N33/56972 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/122 ,  A61K2039/515 ,  C12N5/0636 ,  G01N33/505 ,  G01N2333/70514 ,  G01N2333/70517 ,  G01N2333/70596 ,  G01N2333/7155

摘要： The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.

摘要翻译： 本发明提供了分离能够大量富集FoxP3的CD127lo / - 免疫抑制性调节性T细胞的方法，扩增分离的细胞的方法，这种细胞的药物组合物及其用于治疗自身免疫和其他免疫系统介导的病症的方法 。

公开(公告)号：US20150110761A1

公开(公告)日：2015-04-23

申请号：US14382537

申请日：2013-03-01

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Qizhi Tang ,  Jeffrey A. Bluestone

IPC分类号： A61K35/17 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K31/436 ,  A61K31/5377 ,  A61K31/573 ,  A61K39/001 ,  A61K2300/00 ,  C12N5/0635 ,  C12N5/0637 ,  C12N2501/04 ,  C12N2501/2304 ,  C12N2501/515 ,  C12N2502/1107 ,  C12N2502/30

摘要： The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.

摘要翻译： 本公开一般涉及用于免疫治疗的调节性T细胞（Treg）的制造。 特别地，本公开涉及离体扩增同种抗原反应性Treg的有效方法。 以这种方式产生的异源抗原反应性Treg适用于诱导和/或维持同种异体移植受体的免疫耐受性。

公开(公告)号：US11951136B2

公开(公告)日：2024-04-09

申请号：US16772078

申请日：2018-12-12

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Casey Ward ,  Qizhi Tang ,  Peter Stock ,  Gaetano Faleo ,  Gopika Nair ,  Matthias Hebrok ,  Wenhan Chang ,  Thuy Vo ,  Jeffrey A. Bluestone ,  Eleonora De Klerk

IPC分类号： A61P3/10 ,  A61K9/00 ,  A61K35/39 ,  A61K35/55 ,  C12N5/071

CPC分类号： A61K35/55 ,  A61K9/0019 ,  A61K9/0024 ,  A61K35/39 ,  A61P3/10 ,  C12N5/0617 ,  C12N5/0676 ,  A61K2300/00 ,  C12N2506/02 ,  C12N2506/078

摘要： Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

公开(公告)号：US20210340496A1

公开(公告)日：2021-11-04

申请号：US17284396

申请日：2019-10-10

申请人： The Regents of the University of California

发明人： Alexander Marson ,  Jessica T. Cortez ,  Jeffrey A. Bluestone ,  Eric Shifrut ,  Frederic Van Gool

IPC分类号： C12N5/0783 ,  C12N15/90 ,  A61K35/17 ,  C12N15/11 ,  C12N9/22

摘要： Provided herein are compositions and methods for modifying regulatory T cells. The inventors have identified nuclear factors that influence expression of Foxp3, a key transcriptional regulator of Treg cells. Treg cells can be modified by inhibiting and/or overexpressing one or more of these nuclear factors to produce stabilized Treg cells or destabilized Treg cells.

公开(公告)号：US20210017248A1

公开(公告)日：2021-01-21

申请号：US16981168

申请日：2019-03-15

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jeffrey A. Bluestone ,  Qizhi Tang ,  Leonardo M.R. Ferreira

IPC分类号： C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  C12N5/0783 ,  A61K35/17 ,  A61P37/06

摘要： Chimeric antigen receptor (CAR)-expressing T regulatory cells (Tregs) include intracellular co-stimulatory or inhibitory domains based on the biology, functions and activities of Tregs. The co-stimulatory or inhibitory domains modulate the Treg response, thereby, activating or suppressing an effector T cell (Teff) immune response to specific antigens.

公开(公告)号：US10738113B2

公开(公告)日：2020-08-11

申请号：US16133939

申请日：2018-09-18

申请人： Pfizer Inc. ,  The Regents of the University of California ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Isaac J. Rondon ,  Natasha Crellin ,  Paul Bessette ,  Eleonora Trotta ,  Jeffrey A. Bluestone ,  Lauren K. Ely ,  Kenan C. Garcia

IPC分类号： C12N5/00 ,  C12N15/00 ,  C07H21/04 ,  C07K16/24 ,  A61K39/00

摘要： The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.