发明授权
- 专利标题： CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
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申请号： US15958638申请日： 2018-04-20
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公开(公告)号： US11435349B2公开(公告)日： 2022-09-06
- 发明人: Jeffrey A. Bluestone , Weihong Liu , Amy Putnam
- 申请人： The Regents of the University of California
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; G01N33/569 ; A61K39/00 ; G01N33/50 ; A61K35/17 ; A61K35/12
摘要：
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
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