公开(公告)号：US20210282709A1

公开(公告)日：2021-09-16

申请号：US16317966

申请日：2017-06-07

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61K31/192 ,  A61K31/573 ,  A61K31/722 ,  A61K31/616 ,  A61K9/00

Abstract: Devices, kits, and methods for (a) determining the presence and/or concentration of at least one analyte(s) of interest present in a patient's fluid sample and devices and methods of calibration related thereto, and (b) preventing, mitigating, and/or eliminating biofouling of an indwelling, wearable biosensor are disclosed and/or claimed herein.

公开(公告)号：US20200031889A1

公开(公告)日：2020-01-30

申请号：US16599696

申请日：2019-10-11

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden ,  Eric Cowden

IPC: C07K14/475 ,  C12Q1/37 ,  G01N33/68

Abstract: A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.

公开(公告)号：US20230228773A1

公开(公告)日：2023-07-20

申请号：US18001885

申请日：2021-06-28

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  Jon Stradinger ,  David Ledden

IPC: G01N33/80 ,  G01N33/547 ,  G01N1/34

CPC classification number: G01N33/80 ,  G01N33/547 ,  G01N1/34

Abstract: Devices, assemblies, and kits are disclosed for separating and/or metering a plasma sample from a patient's liquid test sample. Also disclosed are methods of producing and using same.

公开(公告)号：US11585808B2

公开(公告)日：2023-02-21

申请号：US17174431

申请日：2021-02-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: G01N33/543 ,  G01N33/487 ,  G01N33/53 ,  G01N33/541 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68 ,  G01N33/74

Abstract: Devices, methods, and kits for detecting at least two analytes present within a small volume single fluid sample obtained from patient for the creation of a multiplexed panel of the various analytes present within the single fluid sample are disclosed.

公开(公告)号：US11480558B2

公开(公告)日：2022-10-25

申请号：US16621009

申请日：2018-06-07

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Satish Kumar Dubey ,  Ashish Kumar Lal ,  Vishal Manjanath Prabhu ,  David Ledden

IPC: G01N33/49 ,  G01N21/05 ,  G01N21/552 ,  G01N21/03

Abstract: A method and a device for determining the concentration of an analyte in whole blood is disclosed. In one embodiment, the method includes generating a plasma layer in the whole blood sample. Furthermore, the method includes exposing the plasma layer to light. The method also includes capturing light reflected from the plasma layer. Additionally, the method includes analyzing the reflected light to determine the concentration of the analyte.

公开(公告)号：US20210164972A1

公开(公告)日：2021-06-03

申请号：US17174431

申请日：2021-02-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: G01N33/543 ,  G01N33/487 ,  G01N33/53 ,  G01N33/541 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68 ,  G01N33/74

Abstract: Devices, methods, and kits for detecting at least two analytes present within a small volume single fluid sample obtained from patient for the creation of a multiplexed panel of the various analytes present within the single fluid sample are disclosed.

公开(公告)号：US20190240667A1

公开(公告)日：2019-08-08

申请号：US16317951

申请日：2017-07-06

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: B01L3/00

CPC classification number: B01L3/527 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2300/044 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0457

Abstract: Devices, kits, and methods for dispensing at least two liquid reagents for use in analyte(s) detection assays are disclosed.

公开(公告)号：US20230210890A1

公开(公告)日：2023-07-06

申请号：US17996086

申请日：2021-04-13

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: A61K31/727 ,  A61K31/7012 ,  A61K45/06

CPC classification number: A61K31/727 ,  A61K31/7012 ,  A61K45/06

Abstract: Compositions and methods of treating COVID-19 are disclosed. The compositions comprise heparin and/or one or more other negatively charged molecules.

公开(公告)号：US11460475B2

公开(公告)日：2022-10-04

申请号：US17265964

申请日：2019-07-31

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Sudipa Galgalkar ,  Ishita Chakraborty ,  Ragavendar Ms ,  David Ledden

IPC: G01N33/72 ,  G01N1/38 ,  G01N1/28

Abstract: A composition of a bilimbin stock and a method of preparation are provided. In one aspect of the invention, the composition includes a base solution. The composition further includes a carbonate salt. Additionally, the composition includes bilimbin. Furthermore, the composition includes human serum albumin.

公开(公告)号：US20220143604A1

公开(公告)日：2022-05-12

申请号：US17593310

申请日：2020-03-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  Jeffrey Mayfield ,  David Ledden

IPC: B01L3/00

Abstract: Microfluidic devices, method for making and using same are disclosed. The microfluidic device can be made by applying a reagent in liquid form into a sample treatment site within a substrate base. The substrate base has hydrophilic properties bordering a flow channel, and has an application site, the sample treatment site and an analytical site. The flow channel is sized and configured so as to draw a sample applied into the application site to the analytical site through the sample treatment site by capillary action. The reagent is freeze-dried within the sample treatment site.