公开(公告)号：US06355776B1

公开(公告)日：2002-03-12

申请号：US09444791

申请日：1999-11-22

Applicant: Franco A. Ferrari ,  Charles Richardson ,  James Chambers ,  Stuart Causey ,  Thomas J. Pollock ,  Joseph Cappello ,  John W. Crissman

Inventor： Franco A. Ferrari ,  Charles Richardson ,  James Chambers ,  Stuart Causey ,  Thomas J. Pollock ,  Joseph Cappello ,  John W. Crissman

IPC: C07K1300

CPC classification number: C07K14/43586 ,  C07K14/78 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33 ,  C07K2319/61 ,  C12N1/06 ,  C12N15/11 ,  C12N15/62 ,  C12N15/66 ,  C12N15/70 ,  C12N15/75

Abstract: Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.

Abstract translation: 提供了包含氨基酸重复单元的新型多肽，以及编码本发明多肽的合成基因。 主题多肽的特征在于包含氨基酸的重复单元，其中重复单元存在于天然存在的蛋白质中，特别是天然存在的结构蛋白质中。 主题多肽可用于各种应用，例如假体装置的结构部件，合成纤维等。

公开(公告)号：US06184348B2

公开(公告)日：2001-02-06

申请号：US08478029

申请日：1995-06-07

Applicant: Franco A. Ferrari ,  Joseph Cappello

Inventor： Franco A. Ferrari ,  Joseph Cappello

IPC: C07K1400

CPC classification number: C07K14/78 ,  C07K14/43586 ,  C07K14/4741 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/74

Abstract: Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.

Abstract translation: 提供了通过重组技术产生的新型聚合物。 聚合物的特征在于具有小的重复序列，其提供能够缔合的链，产生有用的结构特征，其中链通过柔性并可用于与环境相互作用的匝或环连接。 具体地说，重复天然存在的蛋白质如丝绸的组是通过在提供链之间转向的位置处引入氨基酸序列来修饰的，以提供能够与环境中的分子相互作用的容易获得的寡肽。

公开(公告)号：US5830713A

公开(公告)日：1998-11-03

申请号：US707237

申请日：1996-09-03

Applicant: Franco A. Ferrari ,  Joseph Cappello ,  John W. Crissman ,  Mary A. Dorman

Inventor： Franco A. Ferrari ,  Joseph Cappello ,  John W. Crissman ,  Mary A. Dorman

IPC: C12N15/09 ,  C07K14/435 ,  C07K14/78 ,  C12N1/06 ,  C12N15/10 ,  C12N15/11 ,  C12N15/62 ,  C12N15/66 ,  C12N15/70 ,  C12N15/75 ,  C12P21/02 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC classification number: C07K14/43586 ,  C07K14/78 ,  C12N1/06 ,  C12N15/10 ,  C12N15/11 ,  C12N15/62 ,  C12N15/66 ,  C12N15/70 ,  C12N15/75 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33 ,  C07K2319/61

Abstract: Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.

Abstract translation: 提供了使用生化技术生产含有氨基酸重复序列的大多肽的方法，特别是编码大多肽表达的DNA序列。 还提供了利用外源转录和翻译区以控制大多肽的产生的系统。

公开(公告)号：US20180271939A1

公开(公告)日：2018-09-27

申请号：US15927007

申请日：2018-03-20

Applicant: Milton J. Silverman, JR. ,  Franco A. Ferrari

Inventor： Milton J. Silverman, JR. ,  Franco A. Ferrari

IPC: A61K38/17 ,  A61K48/00 ,  A61P35/00

CPC classification number: A61K38/1767 ,  A61K48/0016 ,  A61K48/005 ,  A61K48/0075 ,  A61P35/00 ,  C12N15/85 ,  C12N15/88

Abstract: A genetic method to kill cancer by suffocation is presented. The invention involves directly administering a bacterial plasmid in the form of an expression vector to cancer cells or tissue in a patient with cancerous growth. The plasmid is in the form of an expression vector with a nucleic acid encoding the silk protein gene.

公开(公告)号：US5243038A

公开(公告)日：1993-09-07

申请号：US114618

申请日：1987-10-29

Applicant: Franco A. Ferrari ,  Charles Richardson ,  James Chambers ,  Stuart C. Causey ,  Thomas J. Pollock ,  Joseph Capello ,  John W. Crissman

Inventor： Franco A. Ferrari ,  Charles Richardson ,  James Chambers ,  Stuart C. Causey ,  Thomas J. Pollock ,  Joseph Capello ,  John W. Crissman

IPC: C07K14/435 ,  C07K14/78 ,  C12N1/06 ,  C12N15/11 ,  C12N15/62 ,  C12N15/70 ,  C12N15/75

CPC classification number: C07K14/78 ,  C07K14/43586 ,  C12N1/06 ,  C12N15/11 ,  C12N15/62 ,  C12N15/70 ,  C12N15/75 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/61

Abstract: Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.

Abstract translation: 提供了使用生化技术生产含有氨基酸重复序列的大多肽的方法，特别是编码大多肽表达的DNA序列。 还提供了利用外源转录和翻译区以控制大多肽的产生的系统。