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公开(公告)号：US20140079711A1
公开(公告)日：2014-03-20
申请号：US14083762
申请日：2013-11-19
Applicant: Janssen Biotech, Inc.
Inventor： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
IPC: C07K16/28 , C07K14/705
CPC classification number: C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
Abstract: The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
Abstract translation: 本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管发生。 本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。
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公开(公告)号：US20140046031A1
公开(公告)日：2014-02-13
申请号：US13968942
申请日：2013-08-16
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Raymond Sweet
IPC: C07K16/24
CPC classification number: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞，转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US10272152B2
公开(公告)日：2019-04-30
申请号：US15626697
申请日：2017-06-19
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill Giles-Komar , Jinquan Luo , Michael Rycyzyn , Raymond Sweet
IPC: A61K39/395 , C07K16/24 , G01N33/68 , A61K45/06 , A61K39/00
Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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14.发明授权Method of treating an inflammatory condition by administering toll-like 3 receptor antagonists 有权通过施用toll样3受体拮抗剂治疗炎性病症的方法公开(公告)号：US09522957B2
公开(公告)日：2016-12-20
申请号：US13973187
申请日：2013-08-22
Applicant: Janssen Biotech, Inc.
Inventor： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC: A61K39/395 , C07K16/28 , C07H21/04 , C12N15/117 , C07K14/705 , A61K39/00 , C07K16/18 , C12N5/10 , C12N5/12 , C12N15/63
CPC classification number: C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
Abstract translation: 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US20150329634A1
公开(公告)日：2015-11-19
申请号：US14812375
申请日：2015-07-29
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Raymond Sweet
IPC: C07K16/24
CPC classification number: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 抗IL-23抗体，包括编码至少一种抗IL-23抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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Patent Agency Ranking
公开(公告)号：US09127058B2
公开(公告)日：2015-09-08
申请号：US14068670
申请日：2013-10-31
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Raymond Sweet
CPC classification number: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 抗IL-23抗体，包括编码至少一种抗IL-23抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US20240199733A1
公开(公告)日：2024-06-20
申请号：US18444595
申请日：2024-02-16
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Pauchenberger , Raymond Sweet
CPC classification number: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US11939375B2
公开(公告)日：2024-03-26
申请号：US17181778
申请日：2021-02-22
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Rauchenberger , Raymond Sweet
CPC classification number: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US20210188966A1
公开(公告)日：2021-06-24
申请号：US17181778
申请日：2021-02-22
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC: C07K16/24 , A61K9/00 , A61K9/08 , A61K39/395 , A61K47/26
Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US10954297B2
公开(公告)日：2021-03-23
申请号：US16013141
申请日：2018-06-20
Applicant: Janssen Biotech, Inc.
Inventor： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Rauchenberger , Raymond Sweet
Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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