公开(公告)号：US20140079711A1

公开(公告)日：2014-03-20

申请号：US14083762

申请日：2013-11-19

Applicant: Janssen Biotech, Inc.

Inventor： Mark Cunningham ,  Bethany Swencki-Underwood ,  Yi Tang ,  Li Yan

IPC: C07K16/28 ,  C07K14/705

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/70503 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32

Abstract: The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.

Abstract translation: 本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管发生。 本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。