公开(公告)号：US09321836B2

公开(公告)日：2016-04-26

申请号：US14068010

申请日：2014-02-18

Applicant: JANSSEN BIOTECH, INC.

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  A61K38/27 ,  A61K45/06 ,  C07K16/24 ,  G01N33/53 ,  C07K16/42 ,  G01N33/566 ,  A61K39/00

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS: 1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

Abstract translation: 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。

公开(公告)号：US20180334500A1

公开(公告)日：2018-11-22

申请号：US15583487

申请日：2017-05-01

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

公开(公告)号：US09409984B2

公开(公告)日：2016-08-09

申请号：US14190893

申请日：2014-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。

公开(公告)号：US20130171136A1

公开(公告)日：2013-07-04

申请号：US13786440

申请日：2013-03-05

Applicant: Janssen Biotech, Inc. ,  New York University

Inventor： Junming Le ,  Jan T. Vilcek ,  Peter E. Daddona ,  John Ghrayeb ,  David M. Knight ,  Scott A. Siegel

IPC: A61K39/395

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20200062841A1

公开(公告)日：2020-02-27

申请号：US16677120

申请日：2019-11-07

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.

公开(公告)号：US10519231B2

公开(公告)日：2019-12-31

申请号：US16284316

申请日：2019-02-25

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.

公开(公告)号：US09631016B2

公开(公告)日：2017-04-25

申请号：US15132851

申请日：2016-04-19

Applicant: Janssen Biotech, Inc.

Inventor： Yan Chen ,  Debra Gardner ,  David M. Knight ,  Michael W. Lark ,  Bailin Liang ,  David M. Marquis ,  David J. Shealy ,  Eric Michael Smith ,  Xiao-yu R. Song ,  Vedrana Stojanovic-Susulic ,  Raymond W. Sweet ,  Susan Tam ,  Alain P. Vasserot ,  Sheng-Jiun Wu ,  Jing Yang

IPC: A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/248 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2316/96 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: A pen-injector device comprising an anti-IL-6 antibody with a liquid formulation have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20160264659A1

公开(公告)日：2016-09-15

申请号：US15075248

申请日：2016-03-21

Applicant: Janssen Biotech, Inc.

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K9/19 ,  A61K39/395 ,  C07K16/42

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and thera

Abstract translation: 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 对于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和所述方法

公开(公告)号：US09340613B2

公开(公告)日：2016-05-17

申请号：US14096596

申请日：2013-12-04

Applicant: Janssen Biotech, Inc. ,  Applied Molecular Evolution, Inc.

Inventor： Yan Chen ,  Debra Gardner ,  David M. Knight ,  Michael W. Lark ,  Bailin Liang ,  David M. Marquis ,  David J. Shealy ,  Eric Michael Smith ,  Xiao-yu R. Song ,  Vedrana Stojanovic-Susulic ,  Raymond W. Sweet ,  Susan Tam ,  Alain P. Vasserot ,  Sheng-Jiun Wu ,  Jing Yang

IPC: C07K16/24 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/248 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2316/96 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US08703141B2

公开(公告)日：2014-04-22

申请号：US13670918

申请日：2012-11-07

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as Crohn's disease.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如克罗恩病。