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公开(公告)号：US10702523B2
公开(公告)日：2020-07-07
申请号：US16290690
申请日：2019-03-01
IPC分类号： A61K31/5025 , A61K31/196 , A61K38/21 , A61K31/4965 , A61K31/13 , A61K31/215 , A61K31/351 , A61K31/5377 , A61K31/7056 , C07B59/00 , C07D487/04
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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公开(公告)号：US10905767B2
公开(公告)日：2021-02-02
申请号：US16179786
申请日：2018-11-02
发明人： Sergei Gryaznov , Leonid Beigelman , Theodore Yun
IPC分类号： A61K47/54 , A61P31/20 , A61P35/00 , A61K39/39 , A61K47/22 , A61K47/26 , C12Q1/6876 , A61K47/14 , A61K9/00 , A61K31/7088 , A61K39/00
摘要： Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.
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公开(公告)号：US10696708B2
公开(公告)日：2020-06-30
申请号：US15895872
申请日：2018-02-13
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , C07H19/20 , C07H19/16 , C07H19/10 , A61K31/7072 , A61K31/7068 , A61K31/708 , A61K45/06 , A61K31/7076
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US10683320B2
公开(公告)日：2020-06-16
申请号：US16203409
申请日：2018-11-28
IPC分类号： C07H19/207 , C07H19/10 , C07H19/06 , C07H19/20 , C07H19/173 , C07H19/213 , A61P31/14 , C07H19/16
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
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公开(公告)号：US20200079813A1
公开(公告)日：2020-03-12
申请号：US16692858
申请日：2019-11-22
IPC分类号： C07H19/10 , C07H19/207 , C07H19/16 , A61P31/14 , C07H19/213 , C07H19/173 , C07H19/20 , C07H19/06
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
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公开(公告)号：US11149049B2
公开(公告)日：2021-10-19
申请号：US16648405
申请日：2018-09-18
发明人： Leonid Beigelman , Jerome Deval , Marija Prhavc
摘要： Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.
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公开(公告)号：US11021509B2
公开(公告)日：2021-06-01
申请号：US16528414
申请日：2019-07-31
IPC分类号： C07H19/06 , C07H19/207 , C07H19/16 , A61P31/16 , A61K45/06 , C07D405/04 , C07D405/14 , C07D473/18 , C07D473/34 , C07D487/04 , C07D493/04 , C07H19/00 , C07H19/14 , C12N9/12 , C07H19/10 , C07H19/12 , C07H19/20
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US11014935B2
公开(公告)日：2021-05-25
申请号：US15627757
申请日：2017-06-20
发明人： Guangyi Wang , Leonid Beigelman , Anh Truong , Carmela Napolitano , Daniele Andreotti , Haiying He
IPC分类号： C07D409/04 , C07D495/04 , C07D333/58 , C07D215/12 , C07D215/14 , C07D311/68 , C07D215/42 , C07D217/24 , C07D333/16 , C07D333/20 , C07D233/38 , C07D333/50 , C07D333/54 , C07D233/61 , C07D333/62 , C07D333/66 , C07D333/68 , C07D335/06 , C07D233/88 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D261/20 , C07D207/335 , C07D209/08 , C07D209/14 , C07D277/64 , C07D209/86 , C07D213/42 , C07D213/50 , C07D213/65 , C07D213/68 , C07D307/52 , C07D307/81 , C07D233/60 , C07D495/14 , C07C251/84 , A61K45/06 , A61K31/381 , A61K31/404 , A61K31/407 , A61K31/4155 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/506 , C07C243/34 , C07C251/80 , C07C255/34 , A61K31/4164 , A61K31/426 , A61K31/4436 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5377 , C07D209/20 , C07D233/64 , C07D277/56 , C07D409/06 , C07D409/12 , A61K31/165 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/4196 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4365 , A61K31/4375 , A61K31/4427 , A61K31/4545 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/538 , C07C243/18 , C07C255/66 , C07D215/38 , C07D307/40 , C07D307/91 , C07D333/76 , C07D405/10 , C07D413/14
摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US10793591B2
公开(公告)日：2020-10-06
申请号：US16692858
申请日：2019-11-22
IPC分类号： C07H19/073 , C07H19/173 , C07H19/20 , C07H19/207 , C07H19/10 , C07H19/06 , C07H19/213 , A61P31/14 , C07H19/16
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
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公开(公告)号：US10780105B2
公开(公告)日：2020-09-22
申请号：US16105859
申请日：2018-08-20
发明人： Lawrence M. Blatt , Leonid Beigelman , Natalia Dyatkina , Julian Alexander Symons , David Bernard Smith
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7068 , A61K31/708 , A61K31/7072 , A61K31/7076 , A61K31/7052 , A61K31/706 , A61K31/7064
摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
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