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公开(公告)号：US11312727B1
公开(公告)日：2022-04-26
申请号：US17284162
申请日：2019-10-09
发明人： Robert Than Hendricks , Antitsa Dimitrova Stoycheva , Jean-François Bonfanti , Pierre Jean-Marie Bernard Raboisson , Jérôme Michel Claude Fortin , Guillaume Jean Maurice Mercey
IPC分类号： C07D498/22 , A61P31/16 , C07D495/22 , C07D498/18 , C07D471/22 , C07D471/18
摘要： The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.
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公开(公告)号：US12077757B2
公开(公告)日：2024-09-03
申请号：US17063080
申请日：2020-10-05
发明人： Sergei Gryaznov , Leonid Beigelman , Antitsa Dimitrova Stoycheva , Saul Martinez Montero , Jin Hong , Rajendra K. Pandey , Vivek Kumar Rajwanshi , Lakshmipathi Pandarinathan , Yi Jin , Bharat Baral
IPC分类号： C07H21/02 , A61K31/712 , A61K31/7125 , A61K47/54 , A61P31/20 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1131 , A61K31/712 , A61K31/7125 , A61K47/549 , A61P31/20 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/314 , C12N2310/3145 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/344 , C12N2310/351 , C12N2320/32 , C12N2310/321 , C12N2310/3525
摘要： Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.
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公开(公告)号：US10793859B2
公开(公告)日：2020-10-06
申请号：US15705137
申请日：2017-09-14
发明人： Sergei Gryaznov , Leonid Beigelman , Antitsa Dimitrova Stoycheva , Saul Martinez Montero , Jin Hong , Rajendra K. Pandey , Vivek Kumar Rajwanshi , Lakshmipathi Pandarinathan , Yi Jin , Bharat Baral
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11 , A61K31/712 , A61K47/54 , A61P31/20 , A61K31/7125
摘要： Modified oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use, e.g., against HBV are disclosed.
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公开(公告)号：US20200030328A1
公开(公告)日：2020-01-30
申请号：US16537396
申请日：2019-08-09
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/13 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/4965 , A61K31/5377 , A61K31/7056 , A61K38/21 , C07B59/00
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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公开(公告)号：US10980805B2
公开(公告)日：2021-04-20
申请号：US16537396
申请日：2019-08-09
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/13 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/4965 , A61K31/5377 , A61K31/7056 , A61K38/21 , C07B59/00
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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公开(公告)号：US10702523B2
公开(公告)日：2020-07-07
申请号：US16290690
申请日：2019-03-01
IPC分类号： A61K31/5025 , A61K31/196 , A61K38/21 , A61K31/4965 , A61K31/13 , A61K31/215 , A61K31/351 , A61K31/5377 , A61K31/7056 , C07B59/00 , C07D487/04
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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