公开(公告)号：US20210106604A1

公开(公告)日：2021-04-15

申请号：US17001512

申请日：2020-08-24

申请人： Janssen BioPharma, Inc.

发明人： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC分类号： A61K31/7068 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7076

摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

公开(公告)号：US10780105B2

公开(公告)日：2020-09-22

申请号：US16105859

申请日：2018-08-20

申请人： Janssen BioPharma, Inc.

发明人： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7068 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064

摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

公开(公告)号：US10696708B2

公开(公告)日：2020-06-30

申请号：US15895872

申请日：2018-02-13

申请人： Janssen BioPharma, Inc.

发明人： Natalia Dyatkina ,  Guangyi Wang ,  Leonid Beigelman ,  Vivek Kumar Rajwanshi

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/06 ,  C07H19/20 ,  C07H19/16 ,  C07H19/10 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/708 ,  A61K45/06 ,  A61K31/7076

摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.