-
公开(公告)号：US20190240220A1
公开(公告)日：2019-08-08
申请号：US16238277
申请日：2019-01-02
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/5025 , C07D403/04 , C07D487/04 , C07D407/12 , C07D405/14 , C07D235/06 , C07D403/12 , C07D401/14 , C07D401/12 , A61K31/5377 , C07D405/12
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
-
公开(公告)号：US10213427B2
公开(公告)日：2019-02-26
申请号：US15359012
申请日：2016-11-22
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： C07D235/06 , A61K31/5025 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04 , C07D403/04 , A61K31/5377
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
-
公开(公告)号：US10131667B2
公开(公告)日：2018-11-20
申请号：US15408768
申请日：2017-01-18
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Liang Lu , Wenqing Yao
IPC分类号： C07D471/14 , C07D495/14 , C07D471/20 , C07D471/22 , C07D498/14 , C07D498/22 , C07D491/22
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
-
公开(公告)号：US09873698B2
公开(公告)日：2018-01-23
申请号：US15178838
申请日：2016-06-10
发明人： Wenqing Yao , Jincong Zhuo , Colin Zhang
IPC分类号： A61K31/438 , C07D471/10 , C07D221/20
CPC分类号： C07D471/10
摘要： The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
-
15.发明授权Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 有权取代的咪唑并哒嗪和苯并咪唑作为FGFR3的抑制剂公开(公告)号：US09533954B2
公开(公告)日：2017-01-03
申请号：US14267139
申请日：2014-05-01
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： C07D235/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04 , C07D403/04
CPC分类号： A61K31/5025 , A61K31/5377 , C07D235/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
摘要翻译： 本发明涉及取代的咪唑并哒嗪和取代的苯并咪唑，以及含有它们的药物组合物，它们是可用于治疗癌症和其它疾病的FGFR3抑制剂。
-
16.发明申请公开(公告)号：US20160280708A1
公开(公告)日：2016-09-29
申请号：US15178838
申请日：2016-06-10
发明人： Wenqing Yao , Jincong Zhuo , Colin Zhang
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
摘要翻译： 本发明涉及作为11-β羟基类固醇脱氢酶1型（11βHSD1）的抑制剂的某些螺环化合物，含有该组合物的组合物及其用于治疗糖尿病，肥胖症等疾病的方法。
-
公开(公告)号：US20230002392A1
公开(公告)日：2023-01-05
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4709 , C07D403/06 , A61P35/00
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
-
公开(公告)号：US11261191B2
公开(公告)日：2022-03-01
申请号：US16909686
申请日：2020-06-23
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： C07D487/04 , C07D403/06 , A61P35/00 , A61K31/53 , A61K31/4709
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
-
公开(公告)号：US20210380587A1
公开(公告)日：2021-12-09
申请号：US17337027
申请日：2021-06-02
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Liang Lu , Wenqing Yao
IPC分类号： C07D471/14 , C07D495/14 , C07D471/20 , C07D498/14 , C07D498/22 , C07D471/22 , C07D491/22 , A61P11/00 , A61P1/16 , A61P19/02
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
-
公开(公告)号：US10813930B2
公开(公告)日：2020-10-27
申请号：US16238277
申请日：2019-01-02
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： C07D401/12 , A61K31/5025 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04 , C07D235/06 , C07D403/04 , A61K31/5377
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.04 秒)
