公开(公告)号：US20170174782A1

公开(公告)日：2017-06-22

申请号：US15296454

申请日：2016-10-18

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  C07K16/30 ,  A61K31/675 ,  A61K31/704 ,  A61K31/5517 ,  G01N33/574 ,  A61K49/00

CPC classification number: C07K16/32 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K39/3955 ,  A61K47/68 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6863 ,  A61K49/00 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57415 ,  G01N33/57446 ,  G01N33/57492 ,  G01N2333/82

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20160096893A1

公开(公告)日：2016-04-07

申请号：US14851001

申请日：2015-09-11

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/574 ,  A61K47/48

CPC classification number: C07K16/32 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K39/3955 ,  A61K47/68 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6863 ,  A61K49/00 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57415 ,  G01N33/57446 ,  G01N33/57492 ,  G01N2333/82

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗HER2抗体和免疫缀合物及其使用方法。

公开(公告)号：US20140271634A1

公开(公告)日：2014-09-18

申请号：US14210608

申请日：2014-03-14

Applicant: The Regents of the University of California ,  Genentech, Inc.

Inventor： Mark X. Sliwkowski ,  Wolfgang Michael Korn

IPC: A61K39/395 ,  A61K31/437 ,  A61K31/4523

CPC classification number: A61K39/39558 ,  A61K31/437 ,  A61K31/4523 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and a HER3/EGFR inhibitor (such as MEHD7945A). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract translation: 本发明提供了包含MEK抑制剂（例如GDC-0973或GDC-0623）或其药学上可接受的盐和HER3 / EGFR抑制剂（例如MEHD7945A）的组合。 这些组合对于治疗过度增殖性疾病如癌症特别有用。

公开(公告)号：US20230201210A1

公开(公告)日：2023-06-29

申请号：US18111250

申请日：2023-02-17

Applicant: GENENTECH, INC.

Inventor： Mark X. Sliwkowski ,  Scott Holden ,  Stuart Lutzker ,  Jay Tibbitts ,  Nelson L. Jumbe

IPC: A61K31/5365 ,  A61K31/337 ,  A61K31/416 ,  A61K31/513 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/555 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574 ,  A61K47/68 ,  A61K31/5377 ,  G01N33/50 ,  A61K9/00 ,  C07K16/32

CPC classification number: A61K31/5365 ,  A61K31/337 ,  A61K31/416 ,  A61K31/513 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/555 ,  A61K39/39558 ,  A61K45/06 ,  G01N33/57415 ,  A61K47/6803 ,  A61K47/6855 ,  A61K31/5377 ,  G01N33/5011 ,  A61K9/0019 ,  C07K16/32 ,  G01N33/5044 ,  G01N2500/10 ,  G01N2800/52 ,  A61K2039/507

Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20200255539A1

公开(公告)日：2020-08-13

申请号：US16721525

申请日：2019-12-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  G01N33/574 ,  C07K16/30 ,  A61K49/00 ,  A61K31/704 ,  A61K31/675 ,  A61K31/5517 ,  C07K16/28 ,  A61K39/395 ,  A61K47/68

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20200085840A1

公开(公告)日：2020-03-19

申请号：US16391738

申请日：2019-04-23

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: A61K31/5517 ,  A61K47/68 ,  A61K39/395 ,  C07K16/00 ,  C07K16/32

Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.

公开(公告)号：US10314846B2

公开(公告)日：2019-06-11

申请号：US15438418

申请日：2017-02-21

Applicant: GENENTECH, INC.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: A61K39/395 ,  A61K31/5517 ,  A61K47/68 ,  C07K16/00 ,  C07K16/32

Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.

公开(公告)号：US20170136026A1

公开(公告)日：2017-05-18

申请号：US15414137

申请日：2017-01-24

Applicant: GENENTECH, INC.

Inventor： Mark X. Sliwkowski ,  Scott Holden ,  Stuart Lutzker ,  Jay Tibbitts ,  Nelson L. Jumbe

IPC: A61K31/5365 ,  A61K31/517 ,  A61K39/395 ,  C07K16/32 ,  A61K9/00 ,  A61K31/337 ,  G01N33/50

Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20170095570A1

公开(公告)日：2017-04-06

申请号：US15281830

申请日：2016-09-30

Applicant: Genentech, Inc.

Inventor： Peter Dragovich ,  Thomas Pillow ,  Jack Sadowsky ,  Mark X. Sliwkowski ,  BinQing Wei

IPC: A61K47/48 ,  A61K45/06 ,  C07K16/32 ,  A61K31/5517

CPC classification number: A61K45/06 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/2803 ,  C07K16/32 ,  C07K2317/40 ,  C07K2317/522 ,  C07K2317/567

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.

公开(公告)号：US20160075798A1

公开(公告)日：2016-03-17

申请号：US14946318

申请日：2015-11-19

Applicant: GENENTECH, INC. ,  University of Turku

Inventor： Mark X. Sliwkowski ,  Klaus Elenius ,  Maija Hollmen

IPC: C07K16/40 ,  G01N33/574

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/30 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/71

Abstract: Compositions and methods useful for detecting and treating cancers which express the HER4 JM-a isoform are disclosed.

Abstract translation: 公开了用于检测和治疗表达HER4 JM-a同种型的癌症的组合物和方法。