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公开(公告)号：US06566505B2
公开(公告)日：2003-05-20
申请号：US10059749
申请日：2002-01-29
IPC分类号： C07K1600
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
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12.发明授权公开(公告)号：US06455296B2
公开(公告)日：2002-09-24
申请号：US08865579
申请日：1997-05-29
IPC分类号： C12N964
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
摘要翻译： 本发明提供编码Mch6的分离基因及其功能片段。 还提供了编码Mch6的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch6核苷酸序列的编码链或非编码链的单链或双链核酸。 本发明还提供了分离的Mch6多肽和分离的Mch6多肽的大和小亚基，包括其功能片段。
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公开(公告)号：US06271361B1
公开(公告)日：2001-08-07
申请号：US09257218
申请日：1999-02-25
IPC分类号： C12N1557
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
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14.发明授权MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use 失效MCH4和MCH5，凋亡蛋白酶，核酸编码和使用方法
公开(公告)号：US5786173A
公开(公告)日：1998-07-28
申请号：US665220
申请日：1996-06-14
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
CPC分类号： C12N9/6475 , A61K38/00
摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.
摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。
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公开(公告)号：US06407215B1
公开(公告)日：2002-06-18
申请号：US09376156
申请日：1999-08-17
IPC分类号： C07K1640
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2&agr;, and an inactive isoform of it, Mch2&bgr;, are disclosed. Isolated nucleic acid molecules that encode Mch2&agr; and Mch2&bgr;, respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2&agr; and Mch2&bgr; having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2&agr; or Mch2&bgr;, and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2&agr; and/or Mch2&bgr; are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2&agr; are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译： 公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2alpha及其非活性同种型Mch2beta的成员。 公开了分别编码Mch2alpha和Mch2beta的分离的核酸分子。 公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。 公开了编码具有至少10个核苷酸的Mch2alpha和Mch2beta的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。 公开了包含编码Mch2alpha或Mch2beta的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。 公开了结合Mch2alpha和/或Mch2beta上的表位的抗体。 公开了鉴定Mch2alpha的抑制剂，活化剂和底物的方法。 公开了反义化合物及其使用方法。
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16.发明授权Isoforms of human interleukin-1.beta. converting enzyme and methods of using the same 失效人白细胞介素-1β转换酶的同种型及其使用方法
公开(公告)号：US5856169A
公开(公告)日：1999-01-05
申请号：US391916
申请日：1995-02-21
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/02 , A61P29/00 , A61P37/00 , C12N1/21 , C12N9/64 , C12N9/99 , C12N15/09 , C12R1/19 , G01N33/15 , G01N33/53 , C07H21/04 , C12N5/10 , C12N15/63
CPC分类号： C12N9/6475 , A61K38/00
摘要： Substantially pure interleukin-1 converting enzyme isoforms are disclosed. Pharmaceutical compositions comprising one or more interleukin-1 converting enzyme isoforms are disclosed. Nucleic acid molecules that encode interleukin-1 converting enzyme isoforms, recombinant expression vectors that comprise a nucleic acid sequence that encodes an interleukin-1 converting enzyme isoform, and host cells that comprise recombinant expression vectors that comprise nucleic acid sequences that encode interleukin-1 converting enzyme isoforms are disclosed. Fragments of nucleic acid molecules with sequences encoding interleukin-1 converting enzyme isoform and oligonucleotide molecules that comprise a nucleotide sequence complimentary to fragment of a nucleotide sequence that encodes an interleukin-1 converting enzyme isoform are disclosed. Antibodies which bind to an epitope on interleukin-1 converting enzyme isoforms are disclosed. Methods of identifying inhibitors of ICE isoforms are disclosed.
摘要翻译： 公开了基本上纯的白介素-1转换酶同种型。 公开了包含一种或多种白细胞介素-1转换酶同种型的药物组合物。 编码白细胞介素-1转换酶同种型的核酸分子，包含编码白细胞介素-1转换酶同种型的核酸序列的重组表达载体和包含重组表达载体的宿主细胞，所述重组表达载体包含编码白细胞介素-1转换的核酸序列 公开了酶同种型。 公开了具有编码白细胞介素-1转换酶同种型的序列的核酸分子和包含与编码白细胞介素-1转换酶同种型的核苷酸序列的片段互补的核苷酸序列的寡核苷酸分子的核酸分子的片段。 公开了结合白细胞介素-1转换酶同种型的表位的抗体。 公开了鉴定ICE异构体抑制剂的方法。
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17.发明授权Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same 失效Mch2，凋亡半胱氨酸蛋白酶，以及用于制备的组合物及其使用方法
公开(公告)号：US5672500A
公开(公告)日：1997-09-30
申请号：US446925
申请日：1995-05-18
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/566 , C12N5/10 , C12N15/57
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2.alpha., and an inactive isoform of it, Mch2.beta., are disclosed. Isolated nucleic acid molecules that encode Mch2.alpha. and Mch2.beta., respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2.alpha. and Mch2.beta. having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2.alpha. or Mch2.beta., and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2.alpha. and/or Mch2.beta. are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2.alpha. are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译： 公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2α及其非活性同种型Mch2β的成员。 公开了分别编码Mch2α和Mch2β的分离的核酸分子。 公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。 公开了编码具有至少10个核苷酸的Mch2α和Mch2β的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。 公开了包含编码Mch2α或Mch2β的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。 公开了与Mch2α和/或Mch2β上的表位结合的抗体。 公开了鉴定Mch2α的抑制剂，活化剂和底物的方法。 公开了反义化合物及其使用方法。
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18.发明授权MCH2, an apoptotic cysteine protease, and compositions for making and methods of using the same 有权MCH2，凋亡半胱氨酸蛋白酶，以及用于制备的组合物及其使用方法公开(公告)号：US06359127B1
公开(公告)日：2002-03-19
申请号：US09375256
申请日：1999-08-16
IPC分类号： C07H2102
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2&agr;, and an inactive isoform of it, Mch2&bgr;, are disclosed. Isolated nucleic acid molecules that encode Mch2&agr; and Mch2&bgr;, respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2&agr; and Mch2&bgr; having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2&agr; or Mch2&bgr;, and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2&agr; and/or Mch2&bgr; are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2&agr; are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译： 公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2alpha及其非活性同种型Mch2beta的成员。 公开了分别编码Mch2alpha和Mch2beta的分离的核酸分子。 公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。 公开了编码具有至少10个核苷酸的Mch2alpha和Mch2beta的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。 公开了包含编码Mch2alpha或Mch2beta的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。 公开了结合Mch2alpha和/或Mch2beta上的表位的抗体。 公开了鉴定Mch2alpha的抑制剂，活化剂和底物的方法。 公开了反义化合物及其使用方法。
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19.发明授权
公开(公告)号：US5985640A
公开(公告)日：1999-11-16
申请号：US896885
申请日：1997-07-18
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/566 , C07K14/47
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2.alpha., and an inactive isoform of it, Mch2.beta., are disclosed. Isolated nucleic acid molecules that encode Mch2.alpha. and Mch2.beta., respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2.alpha. and Mch2.beta. having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2.alpha. or Mch2.beta., and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2.alpha. and/or Mch2.beta. are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2.alpha. are disclosed. Antisense compounds and methods of using the same are disclosed.
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20.发明授权Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same 有权Mch2，凋亡半胱氨酸蛋白酶，以及用于制备的组合物及其使用方法
公开(公告)号：US5958720A
公开(公告)日：1999-09-28
申请号：US146331
申请日：1998-09-02
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/566 , C12Q1/37 , C12N9/50
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2.alpha., and an inactive isoform of it, Mch2.beta., are disclosed. Isolated nucleic acid molecules that encode Mch2.alpha. and Mch2.beta., respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2.alpha. and Mch2.beta. having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2.alpha. or Mch2.beta., and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2.alpha. and/or Mch2.beta. are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2.alpha. are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译： 公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2α及其非活性同种型Mch2β的成员。 公开了分别编码Mch2α和Mch2β的分离的核酸分子。 公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。 公开了编码具有至少10个核苷酸的Mch2α和Mch2β的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。 公开了包含编码Mch2α或Mch2β的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。 公开了与Mch2α和/或Mch2β上的表位结合的抗体。 公开了鉴定Mch2α的抑制剂，活化剂和底物的方法。 公开了反义化合物及其使用方法。
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