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21 条记录 (耗时 0.023 秒)

    Antibody that specifically binds an Mch4 polypeptide
    1.
    发明授权
    Antibody that specifically binds an Mch4 polypeptide 有权
    特异性结合Mch4多肽的抗体

    公开(公告)号：US06730779B2

    公开(公告)日：2004-05-04

    申请号：US09952768

    申请日：2001-09-10

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C07K1600

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    Antibody that specifically binds an Mch5 polypeptide
    2.
    发明授权
    Antibody that specifically binds an Mch5 polypeptide 失效
    特异性结合Mch5多肽的抗体

    公开(公告)号：US06897296B2

    公开(公告)日：2005-05-24

    申请号：US10668955

    申请日：2003-09-22

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C07K16/00

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    Apoptotic protease Mch6, nucleic acids encoding same and methods of us
    5.
    发明授权
    Apoptotic protease Mch6, nucleic acids encoding same and methods of us 有权
    凋亡蛋白酶Mch6，编码相同的核酸和使用方法

    公开(公告)号：US06274318B1

    公开(公告)日：2001-08-14

    申请号：US09311760

    申请日：1999-05-13

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    IPC分类号： C12Q168

    CPC分类号： C12N9/6475 ,  C07K16/40

    摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.

    摘要翻译： 本发明提供编码Mch6的分离基因及其功能片段。 还提供了编码Mch6的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch6核苷酸序列的编码链或非编码链的单链或双链核酸。 本发明还提供了分离的Mch6多肽和分离的Mch6多肽的大和小亚基，包括其功能片段。

    Nucleotides encoding immunophilin FKBP46 and fragments thereof
    6.
    发明授权
    Nucleotides encoding immunophilin FKBP46 and fragments thereof 失效
    编码免疫亲和素FKBP46的核苷酸及其片段

    公开(公告)号：US5861498A

    公开(公告)日：1999-01-19

    申请号：US741134

    申请日：1996-10-31

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    IPC分类号： C07K14/47 ,  C07H21/04

    CPC分类号： C07K14/4702

    摘要： A substantially pure protein, immunophilin FKBP46, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes immunophillin FKBP46, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes immunophillin FKBP46, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes immunophillin FKBP46 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes immunophillin FKBP46 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on FKBP46 are disclosed. Methods of identifying immunosuppressive drugs comprising the steps of contacting FKBP46 or a homologous protein derived from yeast with a test compound and determining whether the protein binds to the test compound are disclosed.

    摘要翻译： 公开了一种基本上纯的蛋白质，即免疫亲和素FKBP46。 公开了包含编码免疫抑制素FKBP46的核酸序列的分离的核酸分子。 公开了由编码免疫抑制素FKBP46的核酸序列或其至少10个核苷酸的片段组成的分离的核酸分子。 公开了包含编码免疫球蛋白FKBP46的核酸序列和包含重组表达载体的宿主细胞的重组表达载体。 公开了包含与编码至少5个核苷酸的免疫抑制素FKBP46的核酸序列互补的核苷酸序列的寡核苷酸分子。 公开了与FKBP46上的表位结合的抗体。 鉴定免疫抑制药物的方法包括以下步骤：将FKBP46或衍生自酵母的同源蛋白质与测试化合物接触并确定蛋白质是否与测试化合物结合。

    Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use
    8.
    发明授权
    Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use 有权
    Mch4和Mch5，凋亡蛋白酶，核酸编码和使用方法

    公开(公告)号：US06287795B1

    公开(公告)日：2001-09-11

    申请号：US09291692

    申请日：1999-04-13

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12Q137

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。所述基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    SF caspase-1 and compositions for making and methods of using the same
    9.
    发明授权
    SF caspase-1 and compositions for making and methods of using the same 失效
    SF半胱天冬酶-1及其制备用组合物及其使用方法

    公开(公告)号：US5858778A

    公开(公告)日：1999-01-12

    申请号：US773608

    申请日：1996-12-27

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    IPC分类号： C12N9/64 ,  C12N9/50 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C12N9/6475

    摘要： A substantially pure protein, Caspase-1, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes Caspase-1, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes Caspase-1, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes Caspase-1 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes Caspase-1 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on Caspase-1 are disclosed. Methods of identifying modulators and substrates of Caspase-1 are disclosed.

    摘要翻译： 公开了一种基本上纯的蛋白质半胱天冬酶-1。 公开了包含编码半胱天冬酶-1的核酸序列的分离的核酸分子。 公开了由编码半胱天冬酶-1的核酸序列或其至少10个核苷酸的片段组成的分离的核酸分子。 公开了包含编码半胱天冬酶-1的核酸序列和包含重组表达载体的宿主细胞的重组表达载体。 公开了包含与编码至少5个核苷酸的半胱天冬酶-1的核酸序列互补的核苷酸序列的寡核苷酸分子。 公开了结合Caspase-1上的表位的抗体。 公开了鉴定Caspase-1的调节剂和底物的方法。