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11 条记录 (耗时 0.018 秒)

    Inhibitors of the ICE/ced-3 family of cysteine proteases
    1.
    发明申请
    Inhibitors of the ICE/ced-3 family of cysteine proteases 审中-公开
    ICE / ced-3家族半胱氨酸蛋白酶抑制剂

    公开(公告)号：US20060084613A1

    公开(公告)日：2006-04-20

    申请号：US11241857

    申请日：2005-09-30

    申请人： Robert Ternansky ,  Patricia Gladstone ,  Kevin Tomaselli ,  Bin Chao ,  Steven Linton

    发明人： Robert Ternansky ,  Patricia Gladstone ,  Kevin Tomaselli ,  Bin Chao ,  Steven Linton

    IPC分类号： A61K38/06 ,  C07K5/06

    CPC分类号： C07C311/51 ,  A61K38/05 ,  C07K5/0202

    摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

    摘要翻译： 本发明涉及具有以下结构的新型氧酰二肽ICE / ced-3家族抑制剂化合物：其中A，B，R，R 1，R 1'和P q如本文所定义。 本发明还涉及含有这些化合物中的一种或多种的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤和用于保护 要进行移植手术的器官。

    Antibody that specifically binds an Mch5 polypeptide
    2.
    发明授权
    Antibody that specifically binds an Mch5 polypeptide 失效
    特异性结合Mch5多肽的抗体

    公开(公告)号：US06897296B2

    公开(公告)日：2005-05-24

    申请号：US10668955

    申请日：2003-09-22

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C07K16/00

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use
    5.
    发明授权
    MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use 失效
    MCH4和MCH5，凋亡蛋白酶，核酸编码和使用方法

    公开(公告)号：US5786173A

    公开(公告)日：1998-07-28

    申请号：US665220

    申请日：1996-06-14

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C12P21/06 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    COMPOSITIONS AND METHODS OF ENHANCING SURVIVABILITY AND REDUCING INJURY OF CELLS, TISSUES, ORGANS, AND ORGANISMS UNDER HYPOXIC OR ISCHEMIC CONDITIONS
    7.
    发明申请
    COMPOSITIONS AND METHODS OF ENHANCING SURVIVABILITY AND REDUCING INJURY OF CELLS, TISSUES, ORGANS, AND ORGANISMS UNDER HYPOXIC OR ISCHEMIC CONDITIONS 审中-公开
    组合物和增强活力的方法和降低细胞，组织，器官和有机体或非生物条件下的有机体的损伤

    公开(公告)号：US20070265223A1

    公开(公告)日：2007-11-15

    申请号：US11684968

    申请日：2007-03-12

    申请人： Kevin Tomaselli ,  Thomas Deckwerth

    发明人： Kevin Tomaselli ,  Thomas Deckwerth

    IPC分类号： A61K31/7076 ,  A01N1/02 ,  A61P41/00 ,  A61P9/10

    CPC分类号： A01N1/02 ,  A01N1/0226 ,  A61K31/7076

    摘要： The present invention provides methods, compositions, and articles of manufacture comprising adenosine, an adenosine derivative or analog, an adenosine receptor agonist, a chemical entity that is taken up by a nucleoside transporter, or a chemical entity that binds to and/or modulates a nucleoside transporter, which protect biological material from cellular or tissue damage resulting from ischemia or hypoxia, including ischemia and hypoxia due to injury, disease, or hemorrhaging. These methods, compositions, and articles of manufacture also enhance the survivability of biological material subjected to ischemia due to injury, disease, or hemorrhage.

    摘要翻译： 本发明提供了包括腺苷，腺苷衍生物或类似物，腺苷受体激动剂，被核苷转运蛋白摄取的化学实体或与其结合和/或调节的化学实体的方法，组合物和制品 核苷转运蛋白，其保护生物材料免受由缺血或缺氧引起的细胞或组织损伤，包括由于损伤，疾病或出血引起的缺血和缺氧。 这些方法，组合物和制品也提高了由于损伤，疾病或出血而导致缺血的生物材料的生存性。

    Antibody that specifically binds an Mch4 polypeptide
    8.
    发明授权
    Antibody that specifically binds an Mch4 polypeptide 有权
    特异性结合Mch4多肽的抗体

    公开(公告)号：US06730779B2

    公开(公告)日：2004-05-04

    申请号：US09952768

    申请日：2001-09-10

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C07K1600

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。